Immune Cells in Tumor - predict prog and treatment

markatger
markatger Member Posts: 314
edited March 2014 in Colorectal Cancer #1
Thought below was interesting - Maria

Science 29 September 2006:
Vol. 313. no. 5795, p. 1849
DOI: 10.1126/science.313.5795.1849i
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In the mouse, the immune system can recognize a developing tumor and control its growth, but whether the same is true in humans has been controversial. To investigate the impact of the immune response on the prognosis of cancer patients, Galon et al. (p. 1960; see the news story by Couzin) analyzed tumor-infiltrating immune cells in human colorectal cancers by gene expression profiling and in situ immunohistochemistry. In three independent patient populations, the properties of the immune cells (type, density, and location) within the tumors were a better predictor of recurrence and overall patient survival than tumor histopathology. Thus, information about the immune response in individual cancer patients could help optimize treatment decisions.

Comments

  • JADot
    JADot Member Posts: 709 Member
    #2
    Hi Maria:

    Fascinating! Thanks for posting this. Did they say if the test is commercially available?

    Cheers,
    Ying
  • HowardJ
    HowardJ Member Posts: 474
    #3
    Very interesting. Thank you.

    Howard
  • KathiM
    KathiM Member Posts: 8,028 Member
    #4
    I FIRMLY believe that my breast cancer was controlled for years by my immune system. Then, with the advent of the rectal cancer, my immune system became overloaded and could no longer control either one.
    Thanks for the info!

    Hugs, Kathi

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