cll side effects

my mom, 80 years old, was diagnosed with stage 4 cll - she has had her initial chemo and is now undergoing maintenance chemo - she has developed a side effect that both her oncologist and dermatologist say they have never seen before - the problem starts as a small red discoloration that over the course of a day or so becomes larger and redder - the worse part is the intense itching that she says feels like it comes from deep inside - antibiotics and cremes/medicines have had no affect - she is miserable - any experience or advice - thank you