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bilirubin & liver

lfrjar
Posts: 4
Joined: Feb 2006

My sister has colon cancer with liver mets. Her liver is functioning very poorly so they have had to modify her chemo regimen as not to cause excessive damage to the good liver cells. Anyway, my question being they cannot get her bilirubin level down and aside from saying it is the cancer have not been able to determine a reason why the bilirubin will not drop although all her other liver enzyme tests have improved. Has anyone had any experience with this?

spongebob's picture
spongebob
Posts: 2598
Joined: Apr 2003

lfjar -

Has her bile duct been affected at all? Just guessing, but if her liver can't push out all of the bile it needs to due to some disease process affecting the bile duct, perhaps that's a possible reason?

Not personal experience here, but recent experience of a friend.

I'm no doctor and I didn't even stay at a Holiday Inn Express last night...

- SpongeBob

nanuk's picture
nanuk
Posts: 1362
Joined: Dec 2003

From a website on Liver Function Tests:
" Bilirubin is a yellow fluid produced in the liver when worn-out red blood cells are broken down . Bilirubin can leak out from the liver into the bloodstream if the liver is damaged. When Bilirubin builds up, it can cause yellow jaundice - a yellowing of the eyes and skin, dark urine and light colored feces. The causes of abnormal billirubin levels include:
Viral Hepatitus
Blocked Bile ducts
Other liver diseases
Liver scarring (cirrhosis)

Hope this helps in some way.. Bud

themis01
Posts: 168
Joined: Feb 2005

At one point my mom's bile duct had to be opened with a stint and her bilirubin went from 16 to 2.3 in about 3 weeks.

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