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Clinical trial for neuropathy

jmaddox915's picture
jmaddox915
Posts: 80
Joined: Nov 2009

I received a newsletter today from www.fightcolorectalcancer.org and one of the articles mentioned a trial for neuropathy. Has anyone heard of this or tried it?

lizzydavis's picture
lizzydavis
Posts: 893
Joined: May 2009

I was on a clinical trial for neuropathy. I took alpha-lipoic acid. I believe it helped. I had minor symptoms compared to others.

Study Title: PREVENTION OF CISPLATIN- OR OXALIPLATIN-INDUCED PERIPHERAL NEUROPATHY WITH ALPHA-LIPOIC ACID: A PLACEBO-CONTROLLED PHASE III TRIAL

Description/Intervention: The goal of this clinical research study is to test the effects (good and bad) of alpha-lipoic acid (ALA) in preventing peripheral neuropathy (abnormal, uncomfortable, often painful, sensations and feelings in hands or feet) caused by chemotherapy, as compared to the effect of a placebo. Researchers want to find out if this dietary supplement can help to decrease the symptoms as well.

k1
Posts: 220
Joined: Dec 2009

Can you buy the stuff OTC?

Kim

lizzydavis's picture
lizzydavis
Posts: 893
Joined: May 2009

Yes, you can buy it otc at Walmart, etc.

johnnybegood's picture
johnnybegood
Posts: 1122
Joined: Oct 2008

i have been taking 600mg per day for about a month and a half i can tell some differance because the tingling in my forearms is gone but i stll have it bad in my fingers,calves and feet.i do have a question.i have been getting sharp pains in my toes just like someone was sticking a needle in them.just wondering is anybody else that is done with chemo having this.does this mean its trying to get better? i can only hope....Godbless....johnnybegood

SIGMA
Posts: 2
Joined: Aug 2006

I AM NEW TO THIS SITE AS OF 1/20/10. I HAVE BEEN DONE WITH CHEMO SINCE 1/7/07 AND STILL HAVE BAD P.N. WITH PAIN, STABBING, BURNING, CRAMPING AND NUMBNESS IN TOES, FEET, CALVES, FOREARMS AND FINGERS. AND, YES, MY RIGHT BIG TOE FEELS LIKE NEEDLES ARE STABBING IT IF IT TOUCHES ANYTHING, SOMETIMES AT NIGHT, JUST TOUCHING THE TOP SHEET HURTS. MY NEUROLOGIST SAYS YOU HAVE TO TAKE 2400 MG/DAY ALPHALIPOIC TO DO ANY GOOD. IT CAN GET EXPENSIVE. I HAVE NOT TRIED IT YET.

Kathryn_in_MN's picture
Kathryn_in_MN
Posts: 1258
Joined: Sep 2009

I take ALA on the advice of my certified oncology dietician. 1200mg per day. I've found Target has a much lower price than other places I've looked for this drug. They expect you to take one per day - so that isn't expensive. But to get in 1200, I have to take 6. The bottle goes quickly.

ALA was already proven to significantly help out those with diabetic neuropathy, and the few trials that have been done for chemo neuropathy look promising too.

My problem is I can't really get supplements down the first week of my cycle, so I've not been taking it as religiously as I should.

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