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Can you go back to Irinotecan?

Monicaemilia's picture
Posts: 455
Joined: Nov 2006

Has anyone gone back to Irinotecan after having had tumour growth on Irinotecan. What I mean is, can you go back and try after having had an extended break of, let's say, a year? Monica

Posts: 1961
Joined: Aug 2003

Good question -- I am sorry I don't know the answer.

I have gone back to FOLFOX (oh joy), with a different agent added

And I'm now on xeledo, which is just a variation of 5FU (but SSHH! -- I'm trying to trick my body into thinking it's a new drug).

Good luck with your question and with your path.


rthornton's picture
Posts: 346
Joined: May 2005

I tried Irinotecan for four cycles last year, with little or no results (well, my CEA continued to climb). This year I have mets in both lungs and the pleural lining, so I am trying Irinotecan again, starting my fifth cycle this Friday (infusions for two weeks then a week off), with the intention of enduring six cycles. I get scanned after my fifth cycle to see if it has helped any. I am using it with Xeloda and Avastin. Since I haven't been scanned yet, I don't know if it is really helping. To answer your question about whether others go back to it, I guess that would be a yes ... at least in my case. Then again, my doctor considers a full regimen to be six cycles and I only went through four cycles last spring.

maglets's picture
Posts: 2596
Joined: Jun 2006

wow rthorton...you have been through the wringer ....good luck with all that.

Tara I am with you I just try to trick my body into thinking xeloda is not ever related to 5 FU cuz we did not relate at all. Monica my onc would not put me back on 5 FU bolus...people on this forum will be a lot more knowlegable than I...I even forget the term she called it when you are re-introducing a drug....I think every onc might be different on this but she did not want to try it again because I had such a violent re-action....

we are all so different with our re-actions to chemo....glad I am not an oncologist!


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