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Xeloda side effects

Posts: 18
Joined: Nov 2005

I was Dx stage 3 in Oct.2005, also had my resection that month. Started chemo in Dec. with oxaliplatin and xeloda (oral 5FU). In March I had a severe allergic reaction to the oxy so my onc just kept me on xeloda for the 2 remaining cycles. She triple dosed me to 4500 mg/day and I had terrible side effects-everything and I mean everything that could crack open on my body did. So the last cycle she reduced the dose down to 3000 mg/day and I faired much better. Anyway, I have been off of the xeloda for 2 weeks and my feet and hands are still a problem. I continue to crack and peel on my hands and my fingertips are still sore. My feet still feel numb and burning on the soles when I walk very much. For those of you who were on xeloda and now off, how long did it take for you to get back to normal? Can you tell I am a bit impatient?

Posts: 205
Joined: Feb 2006

My Chemo is oxy/luc/5fu/avistan . I have a little of the cracked, dry skin problem between my toes . But do know what you mean about the finger tips being sore and the bottom of my feet burn when I walk to much as well . I thought this was from the Oxy . So I am curious too .

Posts: 18
Joined: Nov 2005

Hi debralla- yes, the hand and foot stuff is from the xeloda. It is called hand and foot syndrome. If you don't know about it then ask your doctor. It can be mild to very severe. I had it quite severe when I was at 45oo mg/day, but when I had my dose reduced it was better.

Betsydoglover's picture
Posts: 1256
Joined: Jul 2005

Hi, Spok -

I had 6 cycles of Xeloda (plus Avastin and oxaliplatin) for Stage IV disease. Doing great now.

I had 4 cycles at 4000mg/day Xeloda - onc became concerned about my feet (peeling skin) even though it caused me no problem and reduced Xeloda to 3000mg/day for the last two cycles. That resolved all side effects,

The numbness / soreness is probably more related to the oxaliplatin than the Xeloda. I had no long lasting effects from oxaliplatin, but experienced a few days of bad foot neuropathy during my 3rd and 4th cycles.

Regarding the skin issue. I never had bad hand foot syndrome from Xeloda, but I had my last Xeloda on 12/16/05 and I still have to say that the skin on my hands is dry, especially around my cuticles. Very annoying, but also very minor relatively speaking.

Wishing you all the best.

kerry's picture
Posts: 1317
Joined: Jan 2003

Dear spok5,

I have been on Xeloda for over a year now, taking it in various mg's. I have been as high as 3500mg which caused problems with my hands and feet such as peeling, tenderness and the loss of toenails. However, I have thought the benefits of Xeloda (tablet form) are so much better than infusion and I don't get sick from it. I am able to tolerate it much better than other chemos. I also took it with Oxaliplatin for several months and then had to stop because of high liver enzymes due to the Oxaliplatin and continue with just the Xeloda.

When my doctor reduced my dosage by half, my skin and nails began to improve. It took about a couple of months but they are much better. My advice is to daily put creams, lotions, potions, whatever you can find that moisturizes your skin on your feet and hands. I was given a hot wax dipping machine by a friend to dip my hands and feet in daily to keep them soft. I am still on Xeloda and probably will be for a long time. I'm doing fine. Just take some extra TLC with your hands and feet.


nanuk's picture
Posts: 1362
Joined: Dec 2003

find a good nutrition /juicing protocol and follow it. see www.cedarbrookhome.com for a good detox/cleansing program that is reasonable. You will leave with new skin and other benefits.

Posts: 64
Joined: Mar 2006

Hey there, I just came off Xeloda and I had the cracking feet and hands. It has been about 3 weeks and it is getting better. My hands are healing and my feet are getting much better, hang in there and it should be gone soon!

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