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Glutamine And Neuropathy Caused By Chemotherapy

nicktacoma's picture
Posts: 11
Joined: May 2019

Starting chemo in 2 weeks my onc told me about the likelihood of peripheral neuropathy and suggetsed that I buy Glutamine has any one tried this suppliment? Did it help? just trying to get prepaired for up coming treatments.

As always Thank You for the info. 

Trubrit's picture
Posts: 5486
Joined: Jan 2013

It was suggested I take one of the B vitamins, which I did, but it didn't help. I am six years out from treatment and have permanent neuropathy in legs, feet and hands. 

Its a real worry, and you must be dilligent in reporting every tingle to the Onc and nurses during infusion and afterward. 

Don't know anything about Glutamine, sorry. 


Cajun55's picture
Posts: 2
Joined: Jun 2019

Hello, I also had neuropathy after chemo but I soaked in a hot bath with pink Himalayan salt and it relieved the symptoms. Have you tried something similar? I really can't complain about it anymore. 

Posts: 28
Joined: Dec 2017

My doc has me on L-glutamine supplements for the neuropathy.  I have it despite being almost two years off of Folfox.  I think it has helped but really it seems that there is not much out there to really stop the neuropathy once it has gotten bad. 

I had 14 or so Folfox treatments and Have been on folfiri now for about a year. 

the oxliplatin in the folfox is what caused my neuropathy


JanJan63's picture
Posts: 2482
Joined: Sep 2014

Did he say the chances of getting the neuropathy were 92%? I looked it up for my thread on Folfox.


nicktacoma's picture
Posts: 11
Joined: May 2019

Jan he didn't give me a % chance he said around the 5th treatment I should start taking Glutamine because I would most likely start getting Neuropathy 

JanJan63's picture
Posts: 2482
Joined: Sep 2014

I sure hope it helps! It would be wonderful for people to have something that makes the side effects lessen. If it's not unpleasant to take I'd take it sooner than 5 treatments. It doesn't start right away but I'm pretty sure it's less than 5. Good luck with it! I hope it works well and isn't too bad for you.


SandiaBuddy's picture
Posts: 1183
Joined: Apr 2017

Summary article of natural approaches to neuropathy:

Vitamin E may help prevent CIPN. L-glutamine, goshajinkigan, and omega-3 are also promising. Acetyl-L-carnitine may worsen CIPN and alpha-lipoic acid activity is unknown. Electroacupuncture was not superior to placebo.

 See, also:




Posts: 13
Joined: Aug 2017

I started taking glutamine as soon as I was put on FOLFOX. I started to get neuropathy after 8 cycles. I had 14 cycles total, with the last two at reduced strength due to the neuropathy. I've read posts where people have had to stop much sooner than I did. Perhaps the glutamine allowed me to tolerate the oxaliplatin better. It won't prevent neuropathy, but it may delay its onset. 

Annabelle41415's picture
Posts: 6715
Joined: Feb 2009

Believe it was B6 but it didn't work for me and now have permanent neuropathy which happened after infusion 4 for me.  Make sure you talk to your doctor if you find the symptoms you develop are not tolerable.  Mine wouldn't listen to me so that's why mine is permanent.  I'm on Gabapentine daily to help it.  Hope you do well on the treatment.


Posts: 88
Joined: Nov 2017

there is a strong possibility of neuropatyh- you'll have to weigh which is worse, the cancer treatments or losing feelign in your feet- Yuo won't want to quit the cancer treatments too soon- Get as many as you can tolerate- but note that it iwll icnrease chance o neuorpathy- there isn't much you can do to prevent it- it's just one of the costs of having cancer unfortunately- not everyone suffers, but many do- you just gotta hope you are in the minority who don't- Try the things listed in posts above- to stand hte best chance of avoiding it- but note that they likely won't do much-

Sestra17's picture
Posts: 62
Joined: Jan 2018

Hi! Can't be of much help about the glutamine, never was suggested to me. But if your chemo involves Oxaliplatin be vigilant in reporting neuropathy symptoms to the doctor, not just the nurses. I kept telling them all, and they didn't decrease the dose until the last 2 infusions. Two years out I have horrible "crush,burning" pain in my hands and feet. Been on gabapentin and duloxitine with No relief. I'm alive but always in pain.

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