Welcome to the new Cancer Survivors Network website! Existing members can click HERE to review the changes and new features on CSN.

Mixed Response Taxol & Avastin

linmk
linmk Member Posts: 58
edited October 2018 in Uterine Cancer #1

 

I have been on Taxol and Avastin for the last three months. To refresh people's memories I am Stage IVB garden variety endometrial cancer. I have had three different chemo treatments, a hysterectomy, and two clinical trials, the last one was an immunotherapy trial. I won't be able to particpate in another immunotherapy trial because I am MSI-Stable and I didn't have a good response to the immunotherapy. The CT scan this past week showed that the newer places with tumors were responding to the Taxol and Avatin but the tumors in the older places like the lungs were growing. It's called a mixed response. So now I am on my sixth treatment plan, a regime of daily megace and tamoxifen tablets. No more infusions. Only the first chemo of Taxol and Carboplatin wiped out the tumors. I was NED for a brief period of less than three months.

I am supposed to return to MD Anderson in Houston at the end of three months for another CT scan. My left leg is still bothering me. It's because of the Taxol infusion that I had been taking. The pain should go away in a month now that I'm off the Taxol. I hope all is well with everyone.

 

 

Comments

  • Red Corvette
    Red Corvette Member Posts: 114
    Warrior

    You are a strong brave warrior. Keep on fighting.

    Red

  • Northwoodsgirl
    Northwoodsgirl Member Posts: 571
    Linmk

    Keeping you in my thoughts and prayers! I am sorry you are still having that leg pain.  You have gone through so much....((Hug))

    Lori

  • paris11
    paris11 Member Posts: 159
    I have stage 4B uterine

    I have stage 4B uterine cancer. The cancer was DX in 2007.  I have been in remission for four years.  The therapy is tamoxifen and megace.

    Best, Connie 

  • LadyMox
    LadyMox Member Posts: 56
    Good to hear you had some

    Good to hear you had some response, but sorry to hear not all your tumors responded. I hope they can find something that works for the other tumors.

  • NoTimeForCancer
    NoTimeForCancer Member Posts: 2,928 **
    edited October 2018 #6
    linmk, I have been thinking

    linmk, I have been thinking of you.  Thank you for checking in.  Hugs dear one.

  • LisaPizza
    LisaPizza Member Posts: 343 **
    I'm glad to hear from you! I

    I'm glad to hear from you! I hope the experimentation pays off this time, and hope for the day none of us have to be experimented on.

  • Wannabeatit
    Wannabeatit Member Posts: 98
    Hope it works for you. Looks

    Hope it works for you. Looks like Paris 11 has had some good results with the same treatment?

     

  • EZLiving66
    EZLiving66 Member Posts: 1,476 **
    I was wondering how you were

    I was wondering how you were doing. I sure hope this new regiment works for you! 

    Love, 

    Eldri 

  • derMaus
    derMaus Member Posts: 558
    edited October 2018 #10
    paris11 said:

    I have stage 4B uterine

    I have stage 4B uterine cancer. The cancer was DX in 2007.  I have been in remission for four years.  The therapy is tamoxifen and megace.

    Best, Connie 

    Paris, this is hugely

    Paris, this is hugely comforting to know that someone with 4B in 2007 is around and in remission. Thank you for your post, and may I beg you to please put that information on your "About me" page so others can see it? It's immensely comforting.

  • derMaus
    derMaus Member Posts: 558
    Linmk, I'm so glad to hear

    Linmk, I'm so glad to hear from you! I wish all the tumors were shrinking but at least some of them are, which beats the alternative. Has glutamine been of any help to you with the Taxol side effects? You're in my thoughts and prayers. B

  • paris11
    paris11 Member Posts: 159
    derMaus said:

    Paris, this is hugely

    Paris, this is hugely comforting to know that someone with 4B in 2007 is around and in remission. Thank you for your post, and may I beg you to please put that information on your "About me" page so others can see it? It's immensely comforting.

    Will do derMaus.  Briefly I

    Will do derMaus.  Briefly I was Dx stage 4 B. In 2007.  I was 69 years.  I was told I had less than a year.  I seriously considered swimming into the Atlantic Ocean.  Today I am 81 and just returned from an easy swim.  The tamoxifen and megace turned the tide.  My oncologist thinks Its a cure.

  • Armywife
    Armywife Member Posts: 449
    Hugs, Linmk!

    Thank you so much for updating us.  I think of you so often since we ran into each other at MD Anderson!  Praying now that the pain in your leg subsides quickly, and that you have wonderful results with the new protocol.  As a fellow Stage IVB garden variety, I am so encouraged by Paris's comment that the same treatment turned the tide for her!  Please keep us posted, friend!

  • pato58
    pato58 Member Posts: 120
    Linmk

    Keeping you in my thoughts too!
    Have a good weekend Smile

  • LadyMox
    LadyMox Member Posts: 56
    paris11 said:

    Will do derMaus.  Briefly I

    Will do derMaus.  Briefly I was Dx stage 4 B. In 2007.  I was 69 years.  I was told I had less than a year.  I seriously considered swimming into the Atlantic Ocean.  Today I am 81 and just returned from an easy swim.  The tamoxifen and megace turned the tide.  My oncologist thinks Its a cure.

    That is wonderful to hear!

    That is wonderful to hear!

  • hopeful56
    hopeful56 Member Posts: 73
    Linmk,

    Linmk,

    You are in my thoughts and prayers.  I hope your pain is alleviated and all the tumors shrink.

    Sending you hugs.

  • paris11
    paris11 Member Posts: 159
    Dr. Coleman at MDA and Dr.

    Dr. Coleman at MDA and Dr. Brian Slomovitz at Sylvester Cancer in Miami are doing cutting edge research into recurrent EC.

  • cmb
    cmb Member Posts: 751 **
    paris11 said:

    Will do derMaus.  Briefly I

    Will do derMaus.  Briefly I was Dx stage 4 B. In 2007.  I was 69 years.  I was told I had less than a year.  I seriously considered swimming into the Atlantic Ocean.  Today I am 81 and just returned from an easy swim.  The tamoxifen and megace turned the tide.  My oncologist thinks Its a cure.

    Welcome News

    Paris11,

    Thank you so much for checking in and sharing your good news. Women, especially those struggling with late stage cancer, really appreciate hearing about cases like yours. Here's to many more years of wonderful ocean swims.

  • linmk
    linmk Member Posts: 58
    Thank you for all your good wishes

    Paris11, I'm glad to hear that you're doing so well. Many more enjoyable swims. I have two questions: How many different types of treatment did you endure before your oncologist put you on megace and tamoxifen? Were you presented with other choices besides those?

    derMaus, the glutamine does work when I remember to take it. At least it seems to lessen the amount of pain medicine I take. Lately, I've been fighting fatigue, perhaps because of the megace. I seem to need more sleep lately.

    I hope everyone is doing well. Again thank you for your support.

  • MAbound
    MAbound Member Posts: 1,156 **
    edited October 2018 #20
    linmk said:

    Thank you for all your good wishes

    Paris11, I'm glad to hear that you're doing so well. Many more enjoyable swims. I have two questions: How many different types of treatment did you endure before your oncologist put you on megace and tamoxifen? Were you presented with other choices besides those?

    derMaus, the glutamine does work when I remember to take it. At least it seems to lessen the amount of pain medicine I take. Lately, I've been fighting fatigue, perhaps because of the megace. I seem to need more sleep lately.

    I hope everyone is doing well. Again thank you for your support.

    Sleep

    I felt tired a lot on Megace, too, so that is definetly a side effect. I slept so soundly on it without dreaming. Since I've stopped the Megace a couple of weeks ago I'm back to having a very active mind when I sleep and now I am tired because I'm not getting a good night's sleep. I kind of miss the dreamless sleeping.

  • paris11
    paris11 Member Posts: 159
    Apologies for taking so long to respond

    I have had problems resetting my password.

    Long and winding road:

    2007. DX with EC Stage 1:  I had sub optimal debunking surgery at Northwestern.  Chemo was not offered.

     

    2008:  Mets to liver, abdomen and lymph nodes.  TX was Carbo/Taxol.  18 month remission.

    2010: surgery to remove lymph nodes and resection diaphragm.  TX was 6 rounds IP/IV Carbo/Taxol.  31 month remission.

    2013:  Splenectomy and removal of lymph nodes. 6 weeks of radiation to lymph nodes. TX Carbo/Taxol 18 month remission.

    2014:  Tumor growing like a vine around aorta.  I enrolled in hospice.  I requested Tamoxifin/Megace.

    2015:  CT scan showed NED.  43 month remission.

    i am humbled.  I live with gratitude.  I will try to keep up with conversation.

    Connie

  • LisaPizza
    LisaPizza Member Posts: 343 **
    paris11 said:

    Apologies for taking so long to respond

    I have had problems resetting my password.

    Long and winding road:

    2007. DX with EC Stage 1:  I had sub optimal debunking surgery at Northwestern.  Chemo was not offered.

     

    2008:  Mets to liver, abdomen and lymph nodes.  TX was Carbo/Taxol.  18 month remission.

    2010: surgery to remove lymph nodes and resection diaphragm.  TX was 6 rounds IP/IV Carbo/Taxol.  31 month remission.

    2013:  Splenectomy and removal of lymph nodes. 6 weeks of radiation to lymph nodes. TX Carbo/Taxol 18 month remission.

    2014:  Tumor growing like a vine around aorta.  I enrolled in hospice.  I requested Tamoxifin/Megace.

    2015:  CT scan showed NED.  43 month remission.

    i am humbled.  I live with gratitude.  I will try to keep up with conversation.

    Connie

    Thank you so much for sharing

    Thank you so much for sharing, so encouraging. 

  • derMaus
    derMaus Member Posts: 558
    paris11 said:

    Apologies for taking so long to respond

    I have had problems resetting my password.

    Long and winding road:

    2007. DX with EC Stage 1:  I had sub optimal debunking surgery at Northwestern.  Chemo was not offered.

     

    2008:  Mets to liver, abdomen and lymph nodes.  TX was Carbo/Taxol.  18 month remission.

    2010: surgery to remove lymph nodes and resection diaphragm.  TX was 6 rounds IP/IV Carbo/Taxol.  31 month remission.

    2013:  Splenectomy and removal of lymph nodes. 6 weeks of radiation to lymph nodes. TX Carbo/Taxol 18 month remission.

    2014:  Tumor growing like a vine around aorta.  I enrolled in hospice.  I requested Tamoxifin/Megace.

    2015:  CT scan showed NED.  43 month remission.

    i am humbled.  I live with gratitude.  I will try to keep up with conversation.

    Connie

    Connie, this is great; it's

    Connie, this is great; it's beyond encouraging! Might I beg you to cut and paste the info onto your About Me page? I'm sorry to be a pest, I'm bugging everyone to do this. Laughing Your story is a wonderful one, thank you again for sharing it. Best always, B

  • paris11
    paris11 Member Posts: 159
    Will continue to update

    I had tumor testing in 2010 and again in 2014.  Both tests showed Carbo/Taxol recommendation and 98% estroge positive.  I also had an extremely aggressive oncologis.  If CT scan showed a growth, doc would remove it.

  • NoTimeForCancer
    NoTimeForCancer Member Posts: 2,928 **
    Thank you, Connie.  We all

    Thank you, Connie.  We all need to hear these things.  I would agree with B that everyone take a moment to update their "about me" page.  I think we tend to set it up when we first join, but I have clicked on people's names hoping to learn more about what they did for treatments, etc.  Some people just stop coming here and stories like this are important for people to see. 

  • linmk
    linmk Member Posts: 58
    Thanks for continuing conversation

    Connie, You have been through a lot. I see that you've had a lot of carbo/taxol treatments and episodes of NED in between. Carbo/Taxol initially worked well for me for maybe one or two months,  but I only had that combination the first time. This last time it was Carbo/Avastin--mixed results. I don't think that I was tested to see what would work best for my tumors. It was standard Carbo/Taxol, then after that, whatever the Tumor Board recommended. I don't think the Tumor Board recommended the megace/taxmoxifen treatment. The gyneconologist oncologist just told me that that was what I was going to get, given the fact that I wasn't NED but I still wasn't ready for hospice. Good Health to you. Glad to hear from you.

  • paris11
    paris11 Member Posts: 159
    linmk I requested the Tamoxifen/Megace

    The oncologist pushed hard for another TX of Carbo/Taxol.  I had a long recovery after the previous Regime of Carbo/Taxol and I said NO MORE.   The oncologist Reluctantly agreed to try Tamoxifen/Megace.  Now, he twirls around the exam room when he sees me. He seems to think the Tamoxifen/Megace was his recommendation.  I say nothing.

  • Armywife
    Armywife Member Posts: 449
    paris11 said:

    Apologies for taking so long to respond

    I have had problems resetting my password.

    Long and winding road:

    2007. DX with EC Stage 1:  I had sub optimal debunking surgery at Northwestern.  Chemo was not offered.

     

    2008:  Mets to liver, abdomen and lymph nodes.  TX was Carbo/Taxol.  18 month remission.

    2010: surgery to remove lymph nodes and resection diaphragm.  TX was 6 rounds IP/IV Carbo/Taxol.  31 month remission.

    2013:  Splenectomy and removal of lymph nodes. 6 weeks of radiation to lymph nodes. TX Carbo/Taxol 18 month remission.

    2014:  Tumor growing like a vine around aorta.  I enrolled in hospice.  I requested Tamoxifin/Megace.

    2015:  CT scan showed NED.  43 month remission.

    i am humbled.  I live with gratitude.  I will try to keep up with conversation.

    Connie

    Wow!

    You are a WARRIOR PRINCESS.  I'm in awe.

  • SF73
    SF73 Member Posts: 316 **
    paris11 said:

    Apologies for taking so long to respond

    I have had problems resetting my password.

    Long and winding road:

    2007. DX with EC Stage 1:  I had sub optimal debunking surgery at Northwestern.  Chemo was not offered.

     

    2008:  Mets to liver, abdomen and lymph nodes.  TX was Carbo/Taxol.  18 month remission.

    2010: surgery to remove lymph nodes and resection diaphragm.  TX was 6 rounds IP/IV Carbo/Taxol.  31 month remission.

    2013:  Splenectomy and removal of lymph nodes. 6 weeks of radiation to lymph nodes. TX Carbo/Taxol 18 month remission.

    2014:  Tumor growing like a vine around aorta.  I enrolled in hospice.  I requested Tamoxifin/Megace.

    2015:  CT scan showed NED.  43 month remission.

    i am humbled.  I live with gratitude.  I will try to keep up with conversation.

    Connie

    What a journey! I am also in

    What a journey! I am also in awe. Thank you so much for sharing. May I ask if you are still on Megace?

  • SF73
    SF73 Member Posts: 316 **
    linmk said:

    Thank you for all your good wishes

    Paris11, I'm glad to hear that you're doing so well. Many more enjoyable swims. I have two questions: How many different types of treatment did you endure before your oncologist put you on megace and tamoxifen? Were you presented with other choices besides those?

    derMaus, the glutamine does work when I remember to take it. At least it seems to lessen the amount of pain medicine I take. Lately, I've been fighting fatigue, perhaps because of the megace. I seem to need more sleep lately.

    I hope everyone is doing well. Again thank you for your support.

    So glad to read about Paris's

    So glad to read about Paris's story. I hope that tamoxifen and megace would be the answer for you as well, linmk. Sorry about your fatigue. Hope it gets better. Keeping you in my thoughts. 

  • paris11
    paris11 Member Posts: 159
    SF73. Still on Megace

    Yes, I take Megace for three weeks then I take Tamoxifen for three weeks.  It is my understanding that the Megace strengths the activity of the Tamoxifen.  I also take Eliquis to prevent blood clots.

    I am having trouble cutting and pasting.  But I will work on it.

    Connie