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Prostate Cancer Metastasized to my Spine

GeneRose1's picture
GeneRose1
Posts: 64
Joined: Aug 2016

My prostate and surrounding tissues were surgically removed in April 2014 and I also received follow-on radiation treatment and hormone blocking therepy (Firmagon). While my PSA levels declined to almost zero, the weight gain lead to the onset of Type 2 Diabetes. I remained in that condition for nearly two years. Then in 2016 my PSA levels started to climb rapidly. In April 2016, my PSA was 0.08. By the middle of August it had jumped to 1.82 and by the end of December, it was at 3.20. Earlier this week, at my regular three month check-up with my Oncologist, I requested some tests and then had a bone scan and a CT Scan. These tests revealed anomolies on my spine at T-11 and L-4 which jibes with the pain I've been feeling in my lower back and a slight numbness and weakness in my arms for the last few weeks. I'm going to get a bone biopsy on my spine in the next couple of days to try and further clarify the picture for my doctors and will also start with another Oncologist who specializes in Chemotherepy, Hormonal Therepy, and Immunotherepy. Does anyone have any experience with this type of Advanced Prostate Cancer and advise on what seems to work best. I've heard good things about immunotherepy and a new treatment called Xofigo. Thanks for your help.

VascodaGama's picture
VascodaGama
Posts: 3018
Joined: Nov 2010

I am sorry for the advance status. Palliative therapies are usually the sequential in your management but these only provide control. You could aim cure if oligometastases are the case. Please follow these threads;

https://csn.cancer.org/node/296402

https://csn.cancer.org/comment/1509277#comment-1509277

https://csn.cancer.org/comment/1548017

Xofigo is recommended to fight PCa in bone but it has attached side effects which you should check before deciding. In such regards maybe Lu 177 is better. You can read opinions on this matter in this link;
https://pcnrv.blogspot.pt/2016/10/lu-177-psma-617-another-update.html

Best wishes in your continuing journey,

VGama

Old Salt
Posts: 720
Joined: Aug 2014

As a follow up to Vasco's post, the compound that (I think) he refers to (Lu177) is a Lu-177 linked agent (ligand) that binds to PSMA on prostate cancer cells (PSMA is largely specific to prostate cancer cells). This approach has been developed and evaluated in Germany and looks quite promising. It is currently not routinely available in the USA, but there has been a clinical trial at Sloan-Kettering (NYC). The trial has been completed, but results have not been published according to the website clinicaltrials.gov

I believe that one can get treatment in Germany.

PS: Is the immunotherapy that you are considering Provenge? 

Mark58
Posts: 41
Joined: Jun 2004

I have been battling Prostate Cancer for 13 long years. I am currently being given Xofigo or Radium 223. I've had 3 infusions so far. My mets had spread to my spine, hips, and ribs. My most recent psa was 128. I am not having any major side effects from the Xofigo. Better than I had expected since every drug/treatment has side effects. I'm afraid I am running out of options for treatment. I think chemo is my only option left. I have had , Xtandi, Zytiga, Provenge and now Xofigo. I should know by the end of this month whether or not it is working. I am still getting a Lupron shot every 3 months and still taking Zytiga. The Xofigo seems to me to be a logical treatment. Radium is in the same family as Calcium which means it is a bone seeker. It emits alpha particles which are meant to combat cancer cells. I am 71 now and feel very fortunate to be still enjoying life. I'm not sure I have answered your questions. Best of luck to you!!

GeneRose1's picture
GeneRose1
Posts: 64
Joined: Aug 2016

Thanks Mark. I'm 59 and moving to a new phase of this journey. I think the biggest lesson learned for me from all this is to be vigilant and to not accept the "see you in three months" response when action is clearly needed. I am very heartened by your response and wish you all the best. My oncologist says that many new treatments for prostate cancer are coming out and I sincerely hope you find one that gets that PSA down to 0.00. Take care and all the best.

GeneRose1's picture
GeneRose1
Posts: 64
Joined: Aug 2016

Mark, How are things going for you? I've had a lot of tests that show precisely where in my bones the prostate cancer has migrated to. Next Monday I start with Casodex and will take that for quite a while. About two weeks from now, I'll get my first Lupron Shot and will probably be getting those for as long as it continues to work on my cancer. I hope the Xofigo is doing some good for you and gets that PSA down to 0.01. Take care and stay in touch. Best/Gene

Mark58
Posts: 41
Joined: Jun 2004

I have had a setback. I now have a compression fracture on my L1 vertebrae. My Oncologist has postponed the last 3 Xofigo treatments until the Spine Center at Vanderbilt has determined how best to treat my fracture. My PSA is currently at 130.6 .  I am still on Lupron and Zytiga. Hopefully that will keep PSA from rising. One thing after the other. I just take all this one day at a time and live my life as completely as I can. Lupron worked for me about 5 years when it started to slowly rise. Hopefully it will work as well or better for you. I will try to answer any questions you have. Best of luck to you.

Not so Patient
Posts: 4
Joined: Sep 2017

What is your Xofigo infusion interval?

VascodaGama's picture
VascodaGama
Posts: 3018
Joined: Nov 2010

GeneRose and Mark,

Your exchanged discussions are of high interest for all PCa survivors confronting systemic cases (me included). Mark in particular sharing his experience with Xofigo (radium 223) which may be at present the only easy to take medication targetting cure by killing the bandit on the spot (wherever it's glued to bone). This drug has been linked to bone marrow suppression symptoms (decrease in production of cells responsible for providing immunity) and such should be under vigilance. I hope that Mark's vertebrae fracture resolves the soonest for him to continue with Xofigo treatment.

LU 177 commented in my above post is a therapy similar to Xofigo but it covers soft tissues which may turn superior to Xofigo in the treatment of certain PCa cases. LU 177 is now (since Feb 1, 2017) available for trials in the US (news for Old Salt) and the details can be read here;

https://clinicaltrials.gov/ct2/show/NCT00859781

There is a long list of excluding criteria so that one needs to verify if his condition is suitable for the trial. I was glad for reading that the serum creatinine can go high above >2.5 mg/dL, which means that I could apply for participation even with CKD. In any case, this is an opportunity of using such an advanced treatment free of charge, safe and under due care. I am not sure if Mark could be accepted for his Xofigo experience but GeneRose could try discussing the matter with his oncologist, particularly because of his diabetes case. The recommended ADT protocol (Casodex plus Lupron) is palliative and will not improve his status. ADT manages to control the advancement of the bandit but is not so prolonged in aggressive types.

Best wishes for improvements in the treatments of both of you.

VGama

GeneRose1's picture
GeneRose1
Posts: 64
Joined: Aug 2016

Whenever I go see my oncologist, I always print out the latest posts from VascodaGama, Mark58, and Old Salt, and review everything in detail with him and his PA. Mark, you've been in this fight for a long time and it's just a setback. If it was easy, anybody could do this! You've got tons of experience in this fight and I'm certain that you'll figure out a way to keep moving forward. You inspire us all and I'm certain good news is just around the corner. VGama, my Oncologist ruled out Xofigo because he believes I'll respond well to the Casodex and Lupron. He believes this will push my PSAs back down to 1.00 or below and get us back to the point in which we can closely monitor it and respond as necessary. I'll discuss the updates on the Lu-177 trials with him at our next meeting. My CT Scan, Bone Scan, and Bone Biopsy revealed that the cancer has indeed moved into my spine at T11, L4, and in my pelvic region. My pain levels are relatively minor and when they flare up, I've been able to get everything back to normal with Advil Liquid Gels. I'll keep everyone posted as I move forward and hope that everyone's next PSA is 0.01.

Mark58
Posts: 41
Joined: Jun 2004

The Spine Center thinks my back will heal without surgery. I'm hoping they are right. I am taking pain pills only when needed. I am sure there are many pain pills in my future, so I use them sparingly. I can't do much without running out of energy. Fatigue is a real problem for me. I hate it! When my great-granddaughter (20 months) comes over she always wants me to walk her thru the yard along with the dog. I do my best to oblige her when I can, but it breaks my heart when I can't. She is the apple of my eye. She has been such a pleasant distraction for me.

My Oncologist says Taxotere is next for me when I finish with the Xofigo. I dread that for sure. I guess I've read too many stories about Chemo and all the side effects. This is such a personal journey. One of my joys in life has always been anticipation. Planning trips and vacations, looking forward to one thing or another. I've got 3 trips planned for this spring and early summer. I'm just hoping I will have the energy to make them happen. I am keeping no secrets from any of my family regarding my condition. I have worked with folks that kept info about life threatening diseases from everyone including family. I never understood that. As usual, I just have to take it one day at a time. I'll close for now. I'm starting to ramble.

Gleason Score 9...
Posts: 62
Joined: Nov 2016

Mark,

Thank you so much for so honestly sharing your journey...it is real and your attitude is great! One can tell from reading your posts that you get a great deal of meaning out of each day and spending time with your great-granddaughter is precious and invigorating! 

Sending strength to you to go on each of your three trips this spring/summer as well as the walk in the yard with your great-granddaughter. 

Once again...thank you for sharing!

Janice

Rakendra's picture
Rakendra
Posts: 198
Joined: Apr 2013

Mark, you have a great atitude and acceptance of your situation, and I congratulate you.  I Have mentioned in earlier posts the value of meditation.  I would suggest that you Youtube The am That I am meditation of Dr Wayne dyer.  Also check out Eckhart Tolle on Youtube.  Another suggestion is to research Self-Hypnosis.  Meditation, especially with music background, and hypnosis can be a great aid in pain control.  Also consider that at some point the pain may become so intense that you do not want to continue.  If that becomes the case, you may want to plan for that event ahead of time.  Your continuing gratitude and making the most of your time is a lesson for all of us..  With much love, respect and admiration, Swami Rakendra 

VascodaGama's picture
VascodaGama
Posts: 3018
Joined: Nov 2010

Mark,

I appreciate what you write. This is the true story of you as a survivor in this fight. Sadly that many do not share their experiences too. I think you doing it well in informing your family on your symptoms and would suggest for you to talk with them about on how to do the trips even with precarious strength. I also do not sympathize with chemo, but some guys did report good things about the therapy. I guess not every thing is negative.  

Hope Xofigo still manages to turn the situation in your favor and that you see the PSA going down.

Best

VG

GeneRose1's picture
GeneRose1
Posts: 64
Joined: Aug 2016

Mark, I'm really happy that you won't need surgery and that the pain levels are fairly manageable. The fatigue has been an issue for me as well. My work-around has been to take a supplement of B-12 every morning and that seems to help.  I've been on Casodex for the entire month and received my first Lupron injection last week. So far so good on the side effects and the only thing I've noticed is occasional short term memory loss such as a complete blank on whether I took my meds five minutes ago. I think the Firmagon injections were much worse. I had six of those in 2014 & 2015 when the cancer came back after my surgery. THAT was pretty rough with hot flashes, weight gain, and the onset of Type 2 Diabetes. I'm spending a lot of time researching experimental cancer treatments. There's a lot going on and my plan is to get started on one of these trials as soon as it appears that my cancer is back under control. I expect to get my next PSA in August and will probably have a new CT Scan and whole body bone scan at that time as well. If things are looking good, I'm not going to fool around and will be part of the most promising trial that I can qualify for. It's a little frustrating because a lot of of the treatments are for HT resistant PCa and I don't appear to be there yet. Please take care and I hope you find something that knocks down the fatigue. It feels like early spring here in coastal North Carolina and I hope it's pleasant where you're at. Best/Gene

slickjy
Posts: 26
Joined: Jan 2017

After June 2013 prostate removal, my PSA steadily rose, despite subsequent Casodex, 7 weeks pelvic prostate/bed radiation at beginning of 2015 and quarterly Lupron injections.  PSA end of March 2017 was 23.0, has been doubling every 3 months.  PET scan w/Axumin 2 wks ago shows skeletal metastases in ilium and L2 & L5.  I am about to start on the Xofigo treatment.  Mark, how did your Xofigo treatment go?  I saw another post on CSN from someone who had no problems with the Xofigo injections until the 5th one, when he became very ill.  Have you had any adverse reaction?  Gene, has the Casodex/Lupron brought your PSA under control? 

GeneRose1's picture
GeneRose1
Posts: 64
Joined: Aug 2016

Slickjy, Good to hear from you and I hope things are getting better. I started on Casodex at the beginning of February and was on that for a couple of weeks before receiving my first Lupron shot on Feb 20. My last PSA before starting the treatments was 6.6 and I'll get my next PSA and Lupron Shot on May 15. As soon as I know something, I'll post it here. For a while there, my new normal was one continuous hot flash. I also had a lot of pain in my bones (2-3 on a pain scale of 10) that I was able to manage and stay ahead of with Advil Liquid Gels. Now as I get close to the three month mark from my first Lupron Injection, the hot flashes are less severe and the bone pain is much improved. I've been working out a great deal, trying to lose weight and get in the best shape possible to deal with future treatments.

hewhositsoncushions
Posts: 274
Joined: Mar 2017

Sorry to hear you are hitting bumps in the road but sounds like you are owning it!

GeneRose1's picture
GeneRose1
Posts: 64
Joined: Aug 2016

HeWho, Thanks so much. It is remarkable to compare notes with people on this site and learn that, in many cases, our symptoms and outcomes are very similar. Mine and SlickJY's treatment and progression are almost identical. I now spend a great deal of time researching the disease and applying for clinical trials. I think we'll have something approaching a cure within five years and hope that every one of us benefits from that.

slickjy
Posts: 26
Joined: Jan 2017

GeneRose1, you and I are almost mirror images of prostate cancer/treatment.  I am about a year earlier than you, having had surgery in 2013, followed by 2 mos daily radiation &  quarterly Lupron started in Jan 2015.  Casodux started March 2015.  PSA continued to double throughout, every 3 months.  In March, it was 23.0.  Found pc is now in pelvic bone and lower spine, based on PET scan w/Axumin done mid-April.  As stated with you in a thread titled "Xofigo" , I am starting Xofigo tomorrow. Pain has been very minimal throughout all this, a little lower back pain, but that is it. Fingers crossed, hard, that this will work.

hewhositsoncushions
Posts: 274
Joined: Mar 2017

Gene

As my ex-army friend says, the only mindset to have is "press on!". We are lucky compared to those twenty years ago and will in even better state as you say in five years.

C

slickjy
Posts: 26
Joined: Jan 2017

1st one was May 9th.  Have had little, if any, reaction.  Feel like I do get fatigued more quickly than I used to, but even that is not terribly significant.     Mets in lower spine and upper left ilium, I do also notice increasing lower back pain. Next injection is June 6th.  Quarterly PSA check is also that week.  Had been doubling, last was 23.0, so we will see .... Still also getting quarterly lupron injections.

slickjy
Posts: 26
Joined: Jan 2017

Because of low white blood cell count,neutrophyls and hemoglobobin, my 2nd shot has been postponed, hopefully only for a week.  Otherwise, no changes and no real side affects to the radium. PSA test and Lupron scheduled for next week as well.  Hopefully, some evidence of progress will show up! 

GeneRose1's picture
GeneRose1
Posts: 64
Joined: Aug 2016

SlickJY, It that common for one's white blood cell count to decrease like that while getting the Xofigo treatment? I wonder if there's anything that can be done to better prepare for the Xofigo; get in great shape, take supplements, etc.? Hang in there. That Xofigo is going to do the job and kill that bandit.

Max Former Hodgkins Stage 3's picture
Max Former Hodg...
Posts: 3297
Joined: May 2012

Gene,

Most chemos used against blood cancers cause the WBC count to plummet. There is a drug used to fix this: Neulasta.

Neulasta is a "colony stimulating factor," which causes the bone marrow to increase WBC production.  I suppose it may be usable against PCa...most Lymphoma and Leukemia patients receive it.

Link attached,

max

http://chemocare.com/chemotherapy/drug-info/Neulasta.aspx

slickjy
Posts: 26
Joined: Jan 2017

Yes, as Max said, decreased WBC is common with Xofigo treatment.  My blood is closely monitored - every week, and twice in the week before a scheduled Xofigo injection - in order to be aware of any such effect.  My 2nd Xofigo injection has been delayed 2 weeks now beacuse of low and decreasing WBC and neutrophil counts.  Good news, tho, as today I had CBC, and WBC is up significantly (tho still low) and ANC increased slightly as well.  So right now I am scheduled for 2nd Xofigo injection on Tuesday, 6/20/17.  Meantime ...... this week I had PSA tested in prep for quarterly Lupron injection (tomorrow).  Bad news, as PSA is now 70.5, TRIPLE what it was 3 months ago.  Up til now, for the last year my PSA has been doubling every 3 months, so this sudden surge is especially discomforting.  I assume we will contiunue with Xofigo as planned, but I wonder if enzalutamide or some other "stepped up" ADT treatment can be administered in coinjunction with Xofigo??  

Not so Patient
Posts: 4
Joined: Sep 2017

My doctor says increased psa is common with xofigo, as it "irritates" the cancers cells and causes increased psa production.  He says "not a problem".

GeneRose1's picture
GeneRose1
Posts: 64
Joined: Aug 2016

Wow, I wonder what the heck happened!? That PSA surge is pretty worrisome. Hopefully, the Lupron injection will bring it back down to a much better number and hold it there. Has Zytiga been discussed? Fortunately everything else appears to be trending well and the treatments can continue. I still believe that Xofigo is in my future; maybe not this year or the next but I expect it to be on the menu when the Lupron's ability to keep the cancer under control starts to falter. I've been working out like crazy lately, trying to lose weight and get rid of the Type 2 Diabetes that came with the Firmagon injections. I wonder if maintaining excellent physical conditon and taking supplements to build up my immune system would help counter some of the negatives (low WBC) associated with Xofigo. Hang in there. I know things are going to get better.

slickjy
Posts: 26
Joined: Jan 2017

Thanks, Gene for the well-wishes.  PSA has us a bit stumped because I have been on Lupon qrtrly injections since January 2015. Anyway, decision reached last Friday was to postpone 2nd Xofigo tretatment until at least early August (because I will be out of town all of July & fear of lowering WBC again) and start on Zytiga right away (with Prednisone, of course).  I am not crazy about the Zytiga/Prednisone, but I need to get the  PSA down and they tell me that should do it.  (I continue with Lupron, too.)  .... Good luck with your exercise regimen.  If you stay with it consistently, I am sure you will see results! .... I'll post update on 8/1, after my next blood lab work.

Mark58
Posts: 41
Joined: Jun 2004

I apologize for not keeping you guys updated on my condition. I guess after 13 and a half years I have ran out of treatment options. I still get my Lupron injections and am still on Zytiga. My psa is at 264 now. Scheduled for another blood test in 2 weeks. At my last appointment my oncologist said to get things in order, and that I would not be around much longer. My cancer is in my hips, ribs and spine. I have severe fatigue issues. It appears that my activity level per day is limited. When I reach that level, I have to be recliner bound for the rest of the day. I did get to go fishing in May. My son had to help me onto his boat. All my children and grandchildren were there. What a wonderful camping/fishing trip that was!!!! They all came for Father's Day too. I had just been released from the hospital after 3 transfusions for very low hemoglobin. This is a roller coaster ride! I'm hoping to make it to see and hold our 2nd Great-granddaughter the middle of August, see the eclipse, and our 49th anniversary in November. Past that, one can only pray.

I am so thankful for the 13.5 years Vanderbilt Medical Center has given me! I feel that I have received the best treatment possible. They have a great staff!!

I apologize for this post being so negative. Hopefully, something I've written may help one of you. Live your life to it's fullest. Don't put off anything. Keep your family close and informed! I promise to write more often.

 

Grinder
Posts: 441
Joined: Mar 2017

Respect for you, Mark. I know it's hard for us males to rely on others after we have been their stronghold and fortress for so long. Now it is time for your friends and family to show you how much they love you. I greatly value my relationships with family, friends, and in Christ. You can't buy that with money, and better a year with the people who genuinely love you than a decade with wicked people who are using you. I think God kept me from being wealthy so I could have what truly makes a man wealthy. (Although my indolence may have had something to do with it). Have a GREAT year.

GeneRose1's picture
GeneRose1
Posts: 64
Joined: Aug 2016

Mark, Have you tried any of the new immunotherepy treatments that have come out recently? I know you're tired and hurting but you're not done until they pull the sheet over your head. You should keep fighting and never let up on this bandit in your body. There's a lot coming out and I think you should consider trying another team, such as MD Anderson, University of North Carolina Lineburger Cancer Center (they were featured on 60 Minutes recently for their innovative use of Watson, the super computer, to find solutions for cancer) or others to get a fresh perspective on this. I'm pretty sure your kids can handle the logistics of getting you where you need to be. Hang tough. You inspire and strengthen us all. If Jimmy Carter, who was at death's door two months ago and is now hugging everyone on his flight and building houses for the needy, can do it, you can do it ten times over. Best/Gene

VascodaGama's picture
VascodaGama
Posts: 3018
Joined: Nov 2010

Mark,

I appreciate your wishes in updating the folks here. I think you did well in finding the strength to get to that wonderful family trip and now you will need to repeat it for the upcoming eclipse. There will be almost !00 Years since the last USA's solar eclipse occurred. Later in November it will be yours 49th anniversary and still later you will have some more occasions to commemorate. Your oncologist may be wrong in his predictions.

I wonder if you have discussed with him about the LU-177 trial. So far the outcomes have been good. I sincerely hope for your next update with your informing us about good news. You are wonderful my friend.

VG

GeneRose1's picture
GeneRose1
Posts: 64
Joined: Aug 2016

Mark, Please check out this link on a new treatment that works kinda, sorta, like Zytiga. Have those wonderful children of your's figure out the clinical trial and logistics of getting you there & back for this. The world is a much better place with you in it and I hope you don't give up the fight and keep punching. Here's the link:

https://prostatecancernewstoday.com/2017/06/30/galeterone-shows-promise-as-a-next-generation-prostate-cancer-drugs/?utm_source=Prostate+Cancer&utm_campaign=9ecc05196a-RSS_MONDAY_EMAIL_CAMPAIGN&utm_medium=email&utm_term=0_a6d9c27ca8-9ecc05196a-72180173

 

slickjy
Posts: 26
Joined: Jan 2017

Best news is that after 1 month on Zytiga, PSA has decreased from 70 to 51 ..... first decrease in almot 2 years! Staying on daily Zytiga, hope to see continued decreases in PSA.  

Finally, after several delays since 1st Xofigo injection on May 9th, I was able to get #2 this week, on 8/22.  Delays due primarily to low WBC and ANC counts, but those have come back.  I am told that the fact that injections are more than 4 weeks apart will not make a difference.  Hopefully thast is the case, and Xofigo is attacking the skeletal lesions as expected.   Meantime, we will monitor weekly and hopefully be able to stay on track for 3rd injection in 4 weeeks.  (Have had no pain, nor any side effects from either Xofigo or Zytiga.)

Will Doran
Posts: 207
Joined: Sep 2015

Slickjy, Mark,& Gene,

Not exactly sure, but my urologist / surgeon was on a clinical trial for Zytiga.  I missed being able to get on the trial.  It was underway when I was diagnosed.  He mentioned this treatment to me the last time I was in.  My PSA was holding at <0.010 until about 10 months ago.  PSA was at 69 when diagnosed.  Had surgery, radiation and two years on Lupron.  After being off Lupron for over a year now, my PSA remains below 1.00.  PSA came up to 0.155, then to 0334.  This was expected as my testosterone came back to normal.  I think it was Zytiga that he mentioned we might try if the PSA kept coming up.  I'll see what happens next month (Sept.).  I'm up for tons of blood work and appointments with my Urologist and New Chemo Doctor next month.  Dr. M(Urologist) said they had very good results with this treatment.  I think this is what he was talking about.  I do know that it began with a Z.  I know there are others that "begin with a Z", but my wife thinks this is what he was talking about as well.  I'll try anything,  if I can stay off Lupron.  We'll talk more about this next month.

Good luck

Love, Peace and God Bless

Will

Max Former Hodgkins Stage 3's picture
Max Former Hodg...
Posts: 3297
Joined: May 2012

Will,

As you may have read, reports from the last year or two are showing that Zytiga, when given sooner than originally designed for in the perscribing information, has been having dramatic effect for many men.  I don't know if this relates to the Study you missed, but sounds possible.   My friend who passed nearly 4 years ago was an early recipient of Zytiga when it was administered only post-Taxane. At that time it improved suvival by only around 6 months.  The new data is much better and promising.

Good luck and blessings upon your progress,

max

GeneRose1's picture
GeneRose1
Posts: 64
Joined: Aug 2016

That is great news about the Zytiga's effectiveness and that you are pressing on with the Xofigo. Did you just wait for your WBC and ANC to come back up naturally or is there any supplements or meds that can help make this happen? I really hope this does the trick and kills that monster.

slickjy
Posts: 26
Joined: Jan 2017

Thanks for the well-wishes, Will & Gene!  

My blood counts (WBC, ANC) continued to remain "acceptable" post-2nd Xofigo (radium) injection, so this past Tuesday 9/26 I got my 3rd (of 6 total) injection.  No side affect reaction to these injections throughout.  Still on the Zytiga, and my PSA decreased further, from 50 to 48 in last 2 months.  Will, in addition to all that, I continue with Lupron shot every 3 months  - been doing that since Feb 2015.  They tell me that will be "foreever".

Though PET AXUMIN scan in April showed bone lesions as previously described (hence the commencement of Xofigo) , I have had very little pain throughout this whole ordeal.  

Oncologists remain vigilant of blood results, with weekly CBCs and monthly CMPs.  They are expecting combination of Lupron/Zytiga/Xofigo will continue to show positive results.  As long as counts remain acceptable, my 4th Xofigo injection is scheduled for early November.  

Hoping you are also encouraged by your own progress!

 

Slickjy

 

slickjy
Posts: 26
Joined: Jan 2017

PSA had been decreasing since started Zytiga in late June - went from 70.3 on 6/12 to 51.7 on 7/27 to 48.4 on 9/12.  Suddenly, it is RISING, from 48.4 on 9/12 to 57.1 on 9/26 to 60.3 on 10/10.  I had intravenous Xofigo addministered on May 9th, Aug 22nd and Sept 26th.  

As has been the case throughout, I have zero pain, despite having mestastic, castrate-resistant prostate cancer.

Oncologist thought is that Zytiga is not effective, suggesting chemo as next step, which scares the bejeeezus out of me.

If anyone has any advice, I'd sure like to hear.

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