The benefit of fruit and vegetables
Good Morning, ladies,
I came across this article and thought it was interesting. I know that p53 has something to do with my UPSC diagnosis and this article helped me to understand it a little better.
I hope and pray for you all to be healthy and I wish you the best during this holiday season!
Re: p53--Cancer Treatment: How Eating Fruit And Vegetables Can Improve Cancer Patients' Response To Chemotherapy
Jan 13, 2012 - 12:48 pm
Cancer Treatment: How Eating Fruit And Vegetables Can Improve Cancer Patients' Response To Chemotherapy
Now a study by UC Riverside biochemists that focuses on cancer cells reports that ingesting apigenin – a naturally occurring dietary agent found in vegetables and fruit – improves cancer cells' response to chemotherapy.
Xuan Liu, a professor of biochemistry, and Xin Cai, a postdoctoral researcher working in her lab, found that apigenin localizes tumor suppressor p53, a protein, in the cell nucleus – a necessary step for killing the cell that results in some tumor cells responding to chemotherapy.
The study, published in the online early edition of the Proceedings of the National Academy of Sciences, provides a novel approach to conquer tumor resistance to chemotherapy, and suggests an avenue for developing safe chemotherapy via naturally occurring agents.
Normally, cells have low levels of p53 diffused in their cytoplasm and nucleus. When DNA in the nucleus is damaged, p53 moves to the nucleus where it activates genes that stop cell growth and cause cell death. In this way, p53 ensures that cells with damaged DNA are killed.
In many cancers, p53 is rendered inactive by a process called cytoplasmic sequestration. Apigenin is able to activate p53 and transport it into the nucleus, resulting in a stop to cell growth and cell death.
"In therapy you want to kill cancer cells," explained Cai, the first author of the research paper. "But to stop cell growth and to kill the cell, p53 first needs to be moved to the cell's nucleus to function. Apigenin is very effective in localizing p53 this way."
Apigenin is mainly found in fruit (including apples, cherries, grapes), vegetables (including parsley, artichoke, basil, celery), nuts and plant-derived beverages (including tea and wine). It has been shown by researchers to have growth inhibitory properties in several cancer lines, including breast, colon, skin, thyroid and leukemia cells. It has also been shown to inhibit pancreatic cancer cell proliferation.
"Our study advocates the inclusion of vegetables and fruit in our daily diet to help prevent cancer," said Liu, the research paper's coauthor.
The National Institutes of Health supported the five-year study.
Next in their research Liu and Cai plan to design therapies for cancer by finding compounds that are like, but perform better than, apigenin.
url for the epigenetics section for similar articles.
- 118.2K All Discussion Boards
- 5 CSN Information
- 5 Welcome to CSN
- 118.2K Cancer specific
- 2.7K Anal Cancer
- 413 Bladder Cancer
- 294 Bone Cancers
- 1.6K Brain Cancer
- 28K Breast Cancer
- 372 Childhood Cancers
- 27.5K Colorectal Cancer
- 4.5K Esophageal Cancer
- 1.1K Gynecological Cancers (other than ovarian and uterine)
- 12.5K Head and Neck Cancer
- 6.1K Kidney Cancer
- 637 Leukemia
- 756 Liver Cancer
- 4K Lung Cancer
- 4.9K Lymphoma (Hodgkin and Non-Hodgkin)
- 210 Multiple Myeloma
- 7K Ovarian Cancer
- 26 Pancreatic Cancer
- 475 Peritoneal Cancer
- 4.9K Prostate Cancer
- 1.1K Rare and Other Cancers
- 513 Sarcoma
- 686 Skin Cancer
- 630 Stomach Cancer
- 187 Testicular Cancer
- 1.5K Thyroid Cancer
- 5.5K Uterine Cancer
- 6.1K Other Discussion Boards