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ATP depletion

manwithnoname
Posts: 404
Joined: Jun 2012

"Depletion of cellular ATP by inhibition of glycolysis seems to be effective in killing cancer cells with a MDR phenotype. It is known that cells expressing MDR proteins, such as MDR or MRP, require ATP as the energy source to pump the drug substrates out of the cells. Thus, it is possible to overcome such drug resistance by depletion of cellular ATP, causing the pump to fail. "

MDR= Multi Drug Resistant

Agents that deplete ATP

2DG
IV ascorbic acid
Celecoxib
Methyl Jasmonate
Methylglyoxal
Paw Paw cell reg

Radiation + ATP depletion has been curative for advanced cancer in vivo mouse models.

tanstaafl's picture
tanstaafl
Posts: 1292
Joined: Oct 2010

Thanks for the short list, Tony.  The celebrex and IV vitamin C are most doable for our environs.  Mail order might help with the others.             

coloCan
Posts: 1956
Joined: Oct 2009

printouts

http://cancerres.aacrjournals.org/content/early/2011/11/18/0008-5472.CAN-11-1674.abstract

(either of you two familiar with aacr site/research?)l

 

tanstaafl's picture
tanstaafl
Posts: 1292
Joined: Oct 2010

Thanks, it's an interesting abstract, Steve.  I do see Cancer Research papers/abstracts from google but I'm allergic to any $30+ papers.   If you substitute IV vitamin C and celecoxib, per MWNN, for bromopyruvate,  to add to the 5FU-LV part, that's where we're at.  No resistance in the remaining residues yet after 36 months of immunochemo if there's a relationship.

manwithnoname
Posts: 404
Joined: Jun 2012

From what I discovered ATP is needed to power the efflux pump, not all cells have this pump, it's used to pump out chemo, which takes extra energy so more ATP is needed but these cells are very susceptible to ATP depletion.

Paw Paw cell reg seems the easiest to get, loads of info online.

coloCan
Posts: 1956
Joined: Oct 2009

alot of what i read i don't fully comprehend, esp stuff from the more technical sites,such as aacr or pnas or nature;i just "know' its relevant and worthg reading. My brain doesn't function like it used to so i got nowhere when i tried to teach myself elementary biology to better understand some of what i was trying to learn about CRC.So much gets posted/ published every day (tho have you noticed many sites don't add anything on weekends? )(Ever wonder why you have the same amount of people in a hospital on weekends,holidays and nights as you do Monday to Friday, 9 to 5 yet staffing is noticeably reduced? ever be in a hospital bed on a holiday weekend and need immediate medical attention?)

manwithnoname
Posts: 404
Joined: Jun 2012

In the last 3 years I discovered how little I knew about biology chemistry and physics, what I am good at is finding patterns and research. I also like to look at the path least travelled and contrary to what some people on here may think I am very skeptical. 

That's a great observation about hospital, we were in today and I noticed far more religous than secular in the kiddie cancer ward (you can tell here by the clothing) like 90%.

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