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Is the night time the right time for 5-FU?

coloCan
coloCan CSN Member Posts: 1,944 Member
edited April 2013 in Colorectal Cancer #1

Is 5-Fu given via a pump to take home for 46 hours done so because during the night time liver enzymes that detoxify the liver are more abundant than during the day thus making the 5-Fu less toxic?-

 

never thought about this......

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Comments

  • abrub
    abrub CSN Member Posts: 2,174 Member
    #2
    It's because you need the continuous drip of 5FU

    I was told that 5FU has a very short half-life (something like 10 minutes), so that to ensure that there is some active in your system, it is given in a 46 hours drip.

    Alice

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  • coloCan
    coloCan CSN Member Posts: 1,944 Member
    #3
    abrub said:

    It's because you need the continuous drip of 5FU

    I was told that 5FU has a very short half-life (something like 10 minutes), so that to ensure that there is some active in your system, it is given in a 46 hours drip.

    Alice

    i had asked that based on the following article

    from last sentence of second paragraph

    http://medicalxpress.com/print284730928.html

     

    and given the idea that supposedly  2/3s of the efficacy of FOLFOX is derived from the 5-FU it must be pretty potent yet i always thought it was the oxi that was the stronger

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  • tachilders
    tachilders CSN Member Posts: 313
    #4
    coloCan said:

    i had asked that based on the following article

    from last sentence of second paragraph

    http://medicalxpress.com/print284730928.html

     

    and given the idea that supposedly  2/3s of the efficacy of FOLFOX is derived from the 5-FU it must be pretty potent yet i always thought it was the oxi that was the stronger

    Might also be to minimize

    Might also be to minimize side effects. I always get a bolus of about 950mg and then like 5000mg for the 46 hours. 

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  • danker
    danker CSN Member Posts: 1,276 Member
    #5
    abrub said:

    It's because you need the continuous drip of 5FU

    I was told that 5FU has a very short half-life (something like 10 minutes), so that to ensure that there is some active in your system, it is given in a 46 hours drip.

    Alice

    5-fu

    When I was getting 5-fu,it was with a chemo pump delivering 1 1/4 cc Hr 24/7. That lasted all 5 weeks I was getting radiation. 2010 was quite a year, but the resection,ileostomy,and reversal worked! My colonoscopy in 2011 showed NED.  Been NED ever since living a normal(?) life.

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  • coloCan
    coloCan CSN Member Posts: 1,944 Member
    #6
    danker said:

    5-fu

    When I was getting 5-fu,it was with a chemo pump delivering 1 1/4 cc Hr 24/7. That lasted all 5 weeks I was getting radiation. 2010 was quite a year, but the resection,ileostomy,and reversal worked! My colonoscopy in 2011 showed NED.  Been NED ever since living a normal(?) life.

    While i've never heard of this and i doubt you have either

     i wonder what the astronauts have to say about this "risk"

    www.myhealthnewsdaily.com/3711-space-travel-colon-cancer-risk.html

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  • manwithnoname
    manwithnoname CSN Member Posts: 402
    #7
    I did a

    post on circardian rythym and Chemo (here somewhere) ,  the right time makes a huge difference on effiacy and side effects

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