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Switching epoch-r to R-chop

Posts: 3
Joined: Sep 2012

I m knew to the network. I was recently diagnosed with PMBCL and received 4 courses of EPOCh-r. My pet scan after the 2nd one was negative. I had a very hard time with therapy in terms of severe nausea despite all sorts of meds us started to worry about side effects of etoposide such as leukemia down the road, which is very hard to treat. After discussing it with my oncologist, I was switched to RCHOp for the last 2 cycles.
Just wondered if anybody had similar experience.
Thank you!

Max Former Hodg...
Posts: 3705
Joined: May 2012

Hey Madrusia !

A lot of folks here have done r-chop, but of those, I do not know if any also did r-epoch.
I believe Jim did EPOCH, and he will hopefully join here.

R-CHOP is the most common combo for NHL. I did r-abvd, the most common HL combo.

I hope you get the info you need.


jimwins's picture
Posts: 2111
Joined: Aug 2011

Hi Madrusia and welcome to the site. I had Diffuse Large B Cell Lymphoma (stage 2)
and I'm happy to say I'm very close to my first year of remission.
PMBCL is a subset of Diffuse B Cell Lymphoma and R-EPOCH is commonly used
to treat DBCL.

I had 6 cycles of R-EPOCH. My treatment was interrupted
early on for surgery (removed a small section of my small intestine) but
after recovery, I resumed. I was very fortunate that I did not have
major issues with side effects (other than expected).

I suspect you were taken off of the etoposide due to your side effects and the
fact you were responding well after the 2nd cycle. I'm not sure of anyone
here with the exact same circumstances as you but hopefully someone will chime in.

I'm glad you are responding well to treatment and you are most welcome here!
You will find wonderfully supportive folks here.

Hugs and positive thoughts to you,


Posts: 3
Joined: Sep 2012

Thank you so much for your replies and support!
I was initially really excited about the possibility of switching but now worry that maybe I should have "sucked it up", as this is not a very conventional approach. On the other I guess I should trust my oncologist, who is a great guy, that he wouldn't do anything that would jeopardize my outcome.
So glad you guys are doing well! I need those good stories!
Thanks again!

Madrusia (PMBCL, dx June 2012)

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