Welcome to the new Cancer Survivors Network website! Existing members can click HERE to review the changes and new features on CSN.

"Harvard Scientists Discover How Cancer Outwits Erbitux Drug"

coloCan
coloCan Member Posts: 1,944 **
as reported at: bloomberg.com/news/2011-09-07/scientists-discover-how-cancer-outwits-erbitux.html

(and a potential solution)

Comments

  • Buckwirth
    Buckwirth Member Posts: 1,258
    Great Stuff Steve!
    Harvard Scientists Discover How Cancer Outwits Erbitux Drug

    As usual.

    BTW, see Phil's most recent thread...

    Blake
  • PhillieG
    PhillieG Member Posts: 4,866
    Very Promising
    Krysta Pellegrino, a spokeswoman for Roche, said that while the company wasn’t familiar with the research, it thinks that “the hypothesis is scientifically sound.”

    Thanks Steve...
  • laurettas
    laurettas Member Posts: 372
    Buckwirth said:

    Great Stuff Steve!
    Harvard Scientists Discover How Cancer Outwits Erbitux Drug

    As usual.

    BTW, see Phil's most recent thread...

    Blake

    An award
    I hereby bestow the clickable link award to Blake!!

    Now on the the article--what wonderful news!! Trials in six months possibly---Yahooooo!!!!
  • Buckwirth
    Buckwirth Member Posts: 1,258
    PhillieG said:

    Very Promising
    Krysta Pellegrino, a spokeswoman for Roche, said that while the company wasn’t familiar with the research, it thinks that “the hypothesis is scientifically sound.”

    Thanks Steve...

    What!
    Roche did not fund this!

    I am shocked!

    :smile:
  • tanstaafl
    tanstaafl Member Posts: 1,299
    meanwhile...
    "suggest...Herceptin from Roche Holding AG (ROG) might be combined with Erbitux to surmount resistance."
    No doubt awaiting combined toxicity data, if not insurance approvals.


    Cancer-Growth Genes.... generated lung cancer cells in the test tube that were able to evade the effects of Erbitux by making additional copies of a growth- boosting gene called ERBB2, or HER2."

    Erbitux blocks overexpression of ErbB1 (aka EGFR, Endothial Growth Factor Receptor, alias HER1). These researchers are proposing to additionally block Erb2 to make Erbitux treatment effective.

    While they search for a viable monoclonal antibody recipe, we try to modulate any HER2 (ErbB2) overexpression with things like quercetin and menaquinone-4, as described in the literature. One of cimetidine's biological actions is interfering with the cellular growth signals from ErbB1 (aka EGFR), as well as reducing VEGF-A (partly as Avastin does) for those with tumor sourced CA19-9 (and CSLEX1), like the large majority of advanced CRC patients have.

    Cumulatively, my wife has taken cimetidine now for almost 18 months, quercitin for 17 months and menaquinone-4 (a vitamin K2) for about 14 months. We actually got lab data that showed her cimetidine soaked (pre-surgery doses, 800 mg each) tumor cells croaked best when additionally treated with 5FU, ascorbate and menaquinone-4 as chemotherapy, whatever the molecular biology.
  • smokeyjoe
    smokeyjoe Member Posts: 1,425
    tanstaafl said:

    meanwhile...
    "suggest...Herceptin from Roche Holding AG (ROG) might be combined with Erbitux to surmount resistance."
    No doubt awaiting combined toxicity data, if not insurance approvals.


    Cancer-Growth Genes.... generated lung cancer cells in the test tube that were able to evade the effects of Erbitux by making additional copies of a growth- boosting gene called ERBB2, or HER2."

    Erbitux blocks overexpression of ErbB1 (aka EGFR, Endothial Growth Factor Receptor, alias HER1). These researchers are proposing to additionally block Erb2 to make Erbitux treatment effective.

    While they search for a viable monoclonal antibody recipe, we try to modulate any HER2 (ErbB2) overexpression with things like quercetin and menaquinone-4, as described in the literature. One of cimetidine's biological actions is interfering with the cellular growth signals from ErbB1 (aka EGFR), as well as reducing VEGF-A (partly as Avastin does) for those with tumor sourced CA19-9 (and CSLEX1), like the large majority of advanced CRC patients have.

    Cumulatively, my wife has taken cimetidine now for almost 18 months, quercitin for 17 months and menaquinone-4 (a vitamin K2) for about 14 months. We actually got lab data that showed her cimetidine soaked (pre-surgery doses, 800 mg each) tumor cells croaked best when additionally treated with 5FU, ascorbate and menaquinone-4 as chemotherapy, whatever the molecular biology.

    Okay Buck, you amaze me!!!
    Okay Buck, you amaze me!!! When I put my little arrow thingy to your link I get the line "someday Steve will figure out how to do this".....how did you do that!!!
  • smokeyjoe
    smokeyjoe Member Posts: 1,425
    tanstaafl said:

    meanwhile...
    "suggest...Herceptin from Roche Holding AG (ROG) might be combined with Erbitux to surmount resistance."
    No doubt awaiting combined toxicity data, if not insurance approvals.


    Cancer-Growth Genes.... generated lung cancer cells in the test tube that were able to evade the effects of Erbitux by making additional copies of a growth- boosting gene called ERBB2, or HER2."

    Erbitux blocks overexpression of ErbB1 (aka EGFR, Endothial Growth Factor Receptor, alias HER1). These researchers are proposing to additionally block Erb2 to make Erbitux treatment effective.

    While they search for a viable monoclonal antibody recipe, we try to modulate any HER2 (ErbB2) overexpression with things like quercetin and menaquinone-4, as described in the literature. One of cimetidine's biological actions is interfering with the cellular growth signals from ErbB1 (aka EGFR), as well as reducing VEGF-A (partly as Avastin does) for those with tumor sourced CA19-9 (and CSLEX1), like the large majority of advanced CRC patients have.

    Cumulatively, my wife has taken cimetidine now for almost 18 months, quercitin for 17 months and menaquinone-4 (a vitamin K2) for about 14 months. We actually got lab data that showed her cimetidine soaked (pre-surgery doses, 800 mg each) tumor cells croaked best when additionally treated with 5FU, ascorbate and menaquinone-4 as chemotherapy, whatever the molecular biology.

    Search Pubmed, apparently
    Search Pubmed, apparently there is some effect on cocoa on this.....sounds too good to be true but apparently it downregulates expression of this, in test tube samples anyway.
  • coloCan
    coloCan Member Posts: 1,944 **
    smokeyjoe said:

    Okay Buck, you amaze me!!!
    Okay Buck, you amaze me!!! When I put my little arrow thingy to your link I get the line "someday Steve will figure out how to do this".....how did you do that!!!

    Hey Blake........you #$%^%$#$%
    now i get what you mean......Three points for you.....steve

    (one of these days i'll figure it out)
  • Buckwirth
    Buckwirth Member Posts: 1,258
    coloCan said:

    Hey Blake........you #$%^%$#$%
    now i get what you mean......Three points for you.....steve

    (one of these days i'll figure it out)

    :smile:

    :smile: