From England:"....Avastin,Erbitux and Vectibix will not be routinely available on the NHS

coloCan
coloCan Member Posts: 1,944 Member
for people with metastastic bowel cancers, those that have spread to the rest of the body......." Economics$$$$$$$$$$$$$$$$$$$$$$$$$$ so reports The Daily Mail
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Comments

  • John23
    John23 Member Posts: 2,122 Member
    Info

    "NICE says three treatments – Roche’s Avastin, Merck KgAa’s
    Erbitux and Amgen’s Vectibix – are all not cost effective in
    treating metastatic colorectal cancer.

    The Institute concluded the high cost of the drugs could not be
    justified because none of the companies presented convincing data
    to show they significantly extended lives of patients with the disease."


    From here: http://www.inpharm.com/
    (Published on 05/09/11 at 08:59am)

    Better health,

    John
  • coloCan
    coloCan Member Posts: 1,944 Member
    John23 said:

    Info

    "NICE says three treatments – Roche’s Avastin, Merck KgAa’s
    Erbitux and Amgen’s Vectibix – are all not cost effective in
    treating metastatic colorectal cancer.

    The Institute concluded the high cost of the drugs could not be
    justified because none of the companies presented convincing data
    to show they significantly extended lives of patients with the disease."


    From here: http://www.inpharm.com/
    (Published on 05/09/11 at 08:59am)

    Better health,

    John

    current article was/is at:
    dailymail.co.uk/health/article-2033777


    And a positive item from england:"Soil bacteria help Kill cancer tumors" at

    medicalnewstoday.com/articles/233879.php
  • John23
    John23 Member Posts: 2,122 Member
    coloCan said:

    current article was/is at:
    dailymail.co.uk/health/article-2033777


    And a positive item from england:"Soil bacteria help Kill cancer tumors" at

    medicalnewstoday.com/articles/233879.php

    It's easy to get mad.

    But we should be courageous enough to look at the truth,
    rather than the hype.

    If a drug might extend life by up to 3.5 months, is it worth
    spending millions of dollars for it?

    Sorting through the hype and getting to the reality of the
    situation, can be of great comfort, or maddening frustration.

    Cancer patients should be screaming for drugs that work,
    instead of being so complacent to what the industry's promoting.

    We need better than what they've been providing, but nothing
    is going to change unless we face the truth and stop demanding the
    industry continues to profit on drugs that really do not do much
    for our overall survival rate.

    That's my two centavo's worth.

    Best of health,

    John




    MsgBox"('YOU AGREE WITH THAT? Are you crazy?')"

  • PhillieG
    PhillieG Member Posts: 4,866 Member
    ARGH!!!!
    You REALLY want to get pissed off?
    Watch "Gasland" and "Mann vs. Ford" that are showing on HBO.
    "Gasland" tells about how gas/oil companies come in, pump millions of gallons of water that are mixed with 596+ chemicals into the ground, people's water looks like dirty pond water and is flammable, it can be lite on fire, people are sick and many have cancer, and the gas companies say "well PROVE our actions did it to them". Meanwhile no one connected to the gas company would ever drink a sample of the water they insisted was safe for the people who's wells were contaminated.
    While on TV they have an attractive blond woman telling everyone "Gas is Safe and it's Future" and most people go..."well SHE wouldn't lie to us"
    It gives a good examples why so many people have cancer.
    $$$
  • tanstaafl
    tanstaafl Member Posts: 1,313 Member
    lifeboat economics vs cost maximization
    Britain, no longer great, is further down the road to economic devolution. Their system is even more budget constrained, where money spent on one person denies spending to others. Their national insurance system is forced to imperfectly choose, and consider cost-benefits more than our system, with more payers and players, does.

    In fact, the US medical system could be called a cost promoting system, where the most expensive tx, often the least cost effective treatments, are promoted over superior options. This frequently happens when a sexy patent medicine displaces an effective generic. This also one of the issues between alternative medicine protocols that may work well but are not well known, documented or supported, vs newer, FDA approved, patent medicines that consume fortunes with low success rates.

    People are both being distracted from seeking better answers, and being taken hostage for political ransom by this type of bait in the media.
  • PhillieG
    PhillieG Member Posts: 4,866 Member
    John23 said:

    It's easy to get mad.

    But we should be courageous enough to look at the truth,
    rather than the hype.

    If a drug might extend life by up to 3.5 months, is it worth
    spending millions of dollars for it?

    Sorting through the hype and getting to the reality of the
    situation, can be of great comfort, or maddening frustration.

    Cancer patients should be screaming for drugs that work,
    instead of being so complacent to what the industry's promoting.

    We need better than what they've been providing, but nothing
    is going to change unless we face the truth and stop demanding the
    industry continues to profit on drugs that really do not do much
    for our overall survival rate.

    That's my two centavo's worth.

    Best of health,

    John




    MsgBox"('YOU AGREE WITH THAT? Are you crazy?')"

    Why Stats Are Misleading
    John, I was part of an AP Story that was all over the internet about 6 years ago that dealt with the "High Price of Drugs" and if it's worth it. They focused on Avastin. They said something like it extended life by 3 months. OK, I took Avastin for 5 months roughly 90 months ago (7 1/2 years). Here I am!
    Was it worth it? Hell yes!
    Do we need a better way of judging the success of a drug? Hell yes again!
    Do we need to look at more natural ways of dealing with cancer. Again, hell yes!
    -p
  • Sonia32
    Sonia32 Member Posts: 1,071 Member
    tanstaafl said:

    lifeboat economics vs cost maximization
    Britain, no longer great, is further down the road to economic devolution. Their system is even more budget constrained, where money spent on one person denies spending to others. Their national insurance system is forced to imperfectly choose, and consider cost-benefits more than our system, with more payers and players, does.

    In fact, the US medical system could be called a cost promoting system, where the most expensive tx, often the least cost effective treatments, are promoted over superior options. This frequently happens when a sexy patent medicine displaces an effective generic. This also one of the issues between alternative medicine protocols that may work well but are not well known, documented or supported, vs newer, FDA approved, patent medicines that consume fortunes with low success rates.

    People are both being distracted from seeking better answers, and being taken hostage for political ransom by this type of bait in the media.

    Errr
    Are you from the UK? I don't think being in the UK we have as it bad. What I'm hearing about America's financial situation is much worse. Your health system while some of you may pay for it, your actually running out of some cancer drugs???

    Please try not to insult another country if your not from it without facts and figures.

    Avistan has always been not widely available on the NHS, people have had to pay out of pocket for it. In some instances they do get it back if they win their case against the PCT.

    Daily mail, is not a reliable paper, if the news was in the times or telegraph I would be more inclined to believe it.

    Please check out www.bowelcancer.co.uk for more accurate information or cancer research uk.
  • Buckwirth
    Buckwirth Member Posts: 1,258 Member
    PhillieG said:

    ARGH!!!!
    You REALLY want to get pissed off?
    Watch "Gasland" and "Mann vs. Ford" that are showing on HBO.
    "Gasland" tells about how gas/oil companies come in, pump millions of gallons of water that are mixed with 596+ chemicals into the ground, people's water looks like dirty pond water and is flammable, it can be lite on fire, people are sick and many have cancer, and the gas companies say "well PROVE our actions did it to them". Meanwhile no one connected to the gas company would ever drink a sample of the water they insisted was safe for the people who's wells were contaminated.
    While on TV they have an attractive blond woman telling everyone "Gas is Safe and it's Future" and most people go..."well SHE wouldn't lie to us"
    It gives a good examples why so many people have cancer.
    $$$

    Hey Phil!
    Where's my Click This button!!!!
  • laurettas
    laurettas Member Posts: 372
    coloCan said:

    current article was/is at:
    dailymail.co.uk/health/article-2033777


    And a positive item from england:"Soil bacteria help Kill cancer tumors" at

    medicalnewstoday.com/articles/233879.php

    Love it!
    Can we just eat dirt to get this bacteria?! We have lots of that on our farm!
  • Buckwirth
    Buckwirth Member Posts: 1,258 Member
    Sonia32 said:

    Errr
    Are you from the UK? I don't think being in the UK we have as it bad. What I'm hearing about America's financial situation is much worse. Your health system while some of you may pay for it, your actually running out of some cancer drugs???

    Please try not to insult another country if your not from it without facts and figures.

    Avistan has always been not widely available on the NHS, people have had to pay out of pocket for it. In some instances they do get it back if they win their case against the PCT.

    Daily mail, is not a reliable paper, if the news was in the times or telegraph I would be more inclined to believe it.

    Please check out www.bowelcancer.co.uk for more accurate information or cancer research uk.

    Can't we all agree to disagree?
    :smile:


    Love you Sonia, and hope you are doing well. BTW, I also love your political stances in GB!

    Blake
  • John23
    John23 Member Posts: 2,122 Member
    PhillieG said:

    Why Stats Are Misleading
    John, I was part of an AP Story that was all over the internet about 6 years ago that dealt with the "High Price of Drugs" and if it's worth it. They focused on Avastin. They said something like it extended life by 3 months. OK, I took Avastin for 5 months roughly 90 months ago (7 1/2 years). Here I am!
    Was it worth it? Hell yes!
    Do we need a better way of judging the success of a drug? Hell yes again!
    Do we need to look at more natural ways of dealing with cancer. Again, hell yes!
    -p

    Phil
    Re:
    "They focused on Avastin. They said something like it extended
    life by 3 months. OK, I took Avastin for 5 months roughly 90
    months ago"


    Those "stats" were provided by the manufacturers, and they're
    now debating the value of the drugs (cost vs effectiveness) based
    on the stats provided by those manufacturers.

    We all would like to believe that what we've used is what's saved
    our life..... and in some cases, even against the odds presented
    by the industry itself.... Funny, huh?

    Stay well,

    John




    MsgBox"YOU ARE INSAAAAANE"

  • Buckwirth
    Buckwirth Member Posts: 1,258 Member
    John23 said:

    It's easy to get mad.

    But we should be courageous enough to look at the truth,
    rather than the hype.

    If a drug might extend life by up to 3.5 months, is it worth
    spending millions of dollars for it?

    Sorting through the hype and getting to the reality of the
    situation, can be of great comfort, or maddening frustration.

    Cancer patients should be screaming for drugs that work,
    instead of being so complacent to what the industry's promoting.

    We need better than what they've been providing, but nothing
    is going to change unless we face the truth and stop demanding the
    industry continues to profit on drugs that really do not do much
    for our overall survival rate.

    That's my two centavo's worth.

    Best of health,

    John




    MsgBox"('YOU AGREE WITH THAT? Are you crazy?')"

    Up to, or Median?
    What John posted:

    "If a drug might extend life by up to 3.5 months..."

    From the article:

    "...the median overall survival for patients with the normal, or wild-type, version of a gene called KRAS was 23.5 months compared with 20 months on chemotherapy alone."

    The difference is crucial. It means that 50% of the patients in the trial lived LONGER than 23.5 months (the 3.5 month gain you note), in fact, many of them are probably still alive today.

    Please John, take a moment and read up on what Median means.
  • tanstaafl
    tanstaafl Member Posts: 1,313 Member
    Sonia32 said:

    Errr
    Are you from the UK? I don't think being in the UK we have as it bad. What I'm hearing about America's financial situation is much worse. Your health system while some of you may pay for it, your actually running out of some cancer drugs???

    Please try not to insult another country if your not from it without facts and figures.

    Avistan has always been not widely available on the NHS, people have had to pay out of pocket for it. In some instances they do get it back if they win their case against the PCT.

    Daily mail, is not a reliable paper, if the news was in the times or telegraph I would be more inclined to believe it.

    Please check out www.bowelcancer.co.uk for more accurate information or cancer research uk.

    problems and possibilities for all
    Sonia, I was being critical of both countries as needing better solutions, * including treatments that are cheaper, better and already available*. Each system has its peculiarities, patients can get squeezed, or mangled, in either country, hence the "versus" title.

    I was indelicate and I apologize for that. There are several uncomfortable issues here for both the US and UK. To many observers, both countries, perhaps the West broadly, suffer heavy debt, eroded economies, weakened competitive bases, and growing, unsustainable liabilities.

    NHS style coverage is not what the US middle class historically expects as acceptable insurance and hospitalization. In fact, they have long been scared to tears of it.
    .....
    In the year before her cancer diagnosis, my wife lost a favorite cousin unnecessarily under NHS policies. The cousin had developed a serious infection in the hospital, only recognized while casually talking with her sister overseas on the phone. The sister, a doctor, recognized this as an emergency situation that required IV antibiotics, stat. The NHS hospital point blank refused the IV antibiotics, gave oral antibiotics, malpractice where the sister lives. The cousin died less than 24 hrs later, unexpectedly leaving 3 kids.

    I've got my own baggage too. I've got a stage IV wife that probably would not be alive much longer in either the UK or US systems, after a miserable year of hard chemo and/or radiation treatments and some gained months, by the oncologists' own estimates. Actually, I was more worried about her QoL and hardiness under the proposed chemo programs, never mind the cancer. What I also saw, is that there are already simple, cheap, targetable substances that do modulate or inhibit cancer's molecular pathways as well as or better than patent medicines, that have not been pursued in a results oriented way, if at all. Doing alternative/experimental medicine custom fit from the literature, we simply don't fit well with either system - we are doing much better going elsewhere, costing much less, and paying cash.

    [US] health system while some of you may pay for it,...running out of some cancer drugs??? Both systemic flaws, and potentially liable misbehavior, are involved here. There is no shortage of inexpensive drugs like 5FU and leucovorin globally. There are local problems with both FDA and the companies, systemic problems, and perhaps criminal problems.

    Please check out www.bowelcancer.co.uk... "Services for this domain have been discontinued" See, everything is on an off day.
  • Betsydoglover
    Betsydoglover Member Posts: 1,248 Member
    Avastin etc.
    Not trying to start an argument. Avastin has worked for me. As John says, everyone who is doing well thinks what they did worked for them.

    However...........some thoughts about drug statistics.

    1) Most stats come from clinical trials - e.g. Avastin adds 2.5 months to life. Once a drug is approved, there mostly aren't any more significant trials.

    2) A significant percentage of patients participating in trials are already out of other options. Most patients who are doing well are not in trials. So, the improved survival stats for Avastin or any similar drug are going to sound pretty small.

    3) Suppose there was a drug that takes a while to work. Trial patients are typically booted out of the trial if their disease progresses. So, if a drug takes "time" to work, but then works well in some patients, the trial won't have data about those patients. Avastin or Erbitux etc might be drugs like that. Not sure, but it is something to think about.

    Just a few thoughts. I am an Avastin fan and believe that it has saved my life for a while at least!
  • pepebcn
    pepebcn Member Posts: 6,331 Member

    Avastin etc.
    Not trying to start an argument. Avastin has worked for me. As John says, everyone who is doing well thinks what they did worked for them.

    However...........some thoughts about drug statistics.

    1) Most stats come from clinical trials - e.g. Avastin adds 2.5 months to life. Once a drug is approved, there mostly aren't any more significant trials.

    2) A significant percentage of patients participating in trials are already out of other options. Most patients who are doing well are not in trials. So, the improved survival stats for Avastin or any similar drug are going to sound pretty small.

    3) Suppose there was a drug that takes a while to work. Trial patients are typically booted out of the trial if their disease progresses. So, if a drug takes "time" to work, but then works well in some patients, the trial won't have data about those patients. Avastin or Erbitux etc might be drugs like that. Not sure, but it is something to think about.

    Just a few thoughts. I am an Avastin fan and believe that it has saved my life for a while at least!

    Worked wonders on me as well . I'm a fan too!
    Hugs people !
  • pepebcn
    pepebcn Member Posts: 6,331 Member
    Sonia32 said:

    Errr
    Are you from the UK? I don't think being in the UK we have as it bad. What I'm hearing about America's financial situation is much worse. Your health system while some of you may pay for it, your actually running out of some cancer drugs???

    Please try not to insult another country if your not from it without facts and figures.

    Avistan has always been not widely available on the NHS, people have had to pay out of pocket for it. In some instances they do get it back if they win their case against the PCT.

    Daily mail, is not a reliable paper, if the news was in the times or telegraph I would be more inclined to believe it.

    Please check out www.bowelcancer.co.uk for more accurate information or cancer research uk.

    With Avastin or without it at least we got universal healthcare
    here in EU. And you can always have your own private assurance for a very reasonable price!
    Hugs from a member of the European Lobby! hahahaha!
  • herdizziness
    herdizziness Member Posts: 3,624 Member

    Avastin etc.
    Not trying to start an argument. Avastin has worked for me. As John says, everyone who is doing well thinks what they did worked for them.

    However...........some thoughts about drug statistics.

    1) Most stats come from clinical trials - e.g. Avastin adds 2.5 months to life. Once a drug is approved, there mostly aren't any more significant trials.

    2) A significant percentage of patients participating in trials are already out of other options. Most patients who are doing well are not in trials. So, the improved survival stats for Avastin or any similar drug are going to sound pretty small.

    3) Suppose there was a drug that takes a while to work. Trial patients are typically booted out of the trial if their disease progresses. So, if a drug takes "time" to work, but then works well in some patients, the trial won't have data about those patients. Avastin or Erbitux etc might be drugs like that. Not sure, but it is something to think about.

    Just a few thoughts. I am an Avastin fan and believe that it has saved my life for a while at least!

    Jumping on that wagon
    Avastin fan here too!!
    Winter Marie
  • Buckwirth
    Buckwirth Member Posts: 1,258 Member

    Avastin etc.
    Not trying to start an argument. Avastin has worked for me. As John says, everyone who is doing well thinks what they did worked for them.

    However...........some thoughts about drug statistics.

    1) Most stats come from clinical trials - e.g. Avastin adds 2.5 months to life. Once a drug is approved, there mostly aren't any more significant trials.

    2) A significant percentage of patients participating in trials are already out of other options. Most patients who are doing well are not in trials. So, the improved survival stats for Avastin or any similar drug are going to sound pretty small.

    3) Suppose there was a drug that takes a while to work. Trial patients are typically booted out of the trial if their disease progresses. So, if a drug takes "time" to work, but then works well in some patients, the trial won't have data about those patients. Avastin or Erbitux etc might be drugs like that. Not sure, but it is something to think about.

    Just a few thoughts. I am an Avastin fan and believe that it has saved my life for a while at least!

    I would like to add...
    Betsy,

    I hope you don't mind if I add some comments here, you make some good points that I would like to expand on:

    1) Most stats come from clinical trials - e.g. Avastin adds 2.5 months to life. Once a drug is approved, there mostly aren't any more significant trials.

    Actually, the trial size increases. All of our treatments and the course of our disease is followed by both the CDC and the NIH, and outcomes are reviewed by a variety of sources, including the host of our site, ACS.

    2) A significant percentage of patients participating in trials are already out of other options. Most patients who are doing well are not in trials. So, the improved survival stats for Avastin or any similar drug are going to sound pretty small.

    This is an excellent point, and goes to my earlier comment on median vs average. Median is literally the patient in the center, not the mathematical average. So, while the median survival increase might be 3.5 months (an 18% increase, btw) the overall survival rate could be much higher. Avastin, Erbitux and surgery for those with metastasis to a single organ, have lead to a doubling of the five year survival stats among Stage IV patients in the last decade.


    3) Suppose there was a drug that takes a while to work. Trial patients are typically booted out of the trial if their disease progresses. So, if a drug takes "time" to work, but then works well in some patients, the trial won't have data about those patients. Avastin or Erbitux etc might be drugs like that. Not sure, but it is something to think about.

    I'm not sure that is exactly how it works (it would seriously twist the number if it did).

    Erbitux failed the initial trial, not working at all in a significant number of trial participants, but a review of the data identified the importance of the KRAS mutation (or lack of it) in the efficacy of the drug. It was that review that allowed Erbitux to pass the FDA approval process.
  • Buckwirth
    Buckwirth Member Posts: 1,258 Member
    pepebcn said:

    With Avastin or without it at least we got universal healthcare
    here in EU. And you can always have your own private assurance for a very reasonable price!
    Hugs from a member of the European Lobby! hahahaha!

    Thank you Pepe
    maleïda sigui socialista!

    :smile:
  • pepebcn
    pepebcn Member Posts: 6,331 Member
    Buckwirth said:

    Thank you Pepe
    maleïda sigui socialista!

    :smile:

    Hahaha!
    LOL.