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KRAS Mutants.....

coloCan
Posts: 1845
Joined: Oct 2009

while i have no idea what ".....a Colon Cancer GEMM-Derived Orthotopic Transplant Model for Drug Discovery and Validation" is and neither will you by reading this "abstract "-unless you already know what it is) but you might learn a little about Kras mutation in this brief synopsis

http://clincancerres.aacrjournals.org/content/early/2013/02/12/1078-0432.CCR-12-2307.abstract

 

tachilders's picture
tachilders
Posts: 315
Joined: Jun 2012

That's me (KRAS mutant), but at least I'm BRAF wild-type and only Grade 2.  Those last 2 make my prognosis a little beter than BRAF mutant and/or Grade 3.

pete43lost_at_sea's picture
pete43lost_at_sea
Posts: 3915
Joined: Nov 2010

always interesting

we should have kept a count of how many papers we have read, must be over 1000

hugs,

pete

renw's picture
renw
Posts: 282
Joined: Jan 2013

I am another KRAS mutant, a pity as targeting EGFR will most likely not work and that excludes a whole class of antibody treatments after avastin fails.

I can however trump you with a PIK3CA mutation as well as KRAS. :)

renw's picture
renw
Posts: 282
Joined: Jan 2013

The Study say: "Further analyses revealed enrichment for numerous disease-relevant biological pathways, including glucose metabolism. Functional assessment in vitro and in vivo validated this finding and highlighted the dependence of Kras mutant CRC on oncogenic signaling and on aerobic glycolysis."

Seems like giving up all sugars and most carbs was a good call, despite the insistence of my oncologist that I was making a mistake. :)

coloCan
Posts: 1845
Joined: Oct 2009

http://mct.aacrjournals.org/content/12/2/151

 

or this:

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0025132

 

(might want to look at "Discussion" part on this one unless you're science-literate,which i'm not; i know this one's on "wild" but maybe there's info here that might be of use anyway)

Also,maybe something of substance will result fromthis just announced collaboration between Vanderbilt and Gen Elec

http://eon.businesswire.com/news/eon/20130212006193/en/GE/Vanderbilt/cancer

 

 

 

Phil64's picture
Phil64
Posts: 431
Joined: Apr 2012

The following article helped me better understand KRAS and BRAF tests and the implications to treatment for CRCm.

http://emedicine.medscape.com/article/1690010-overview

coloCan
Posts: 1845
Joined: Oct 2009

some potential has been found with something called "gabexate mesilate", tho may not be in US

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