another possible use for mcp modified citrus pectin

pete43lost_at_sea said:

from lef, i just bought 4 normal mcp and 2 chelation mcp
with discounts and free shipping about 48 us dollars per 454g, which is a months supply the way i hammer the stuff, see the link in the other post i did about all the mcp research . it actually blocks the colon cancer receptor.

god i hope this stuff works. so its less the $2 a day or about 50cents per serve

is $12 a week expensive ? i think its reasonable. my doctor almost creamed his pants when he heard i had been on pecta a sol for 14 months. my doctor is going on a conference with the developer and owner of the company. mcp has also won some award for heavy metal chelation.

i am going to get advice directly from the scientist who developed it with regard to managing the chelation and the anti metastatic effect.

hugs,
pete

pete43lost_at_sea said:

thanks winter
the cancer.org warning is fair enough, but its really conventional medicines view which is nice to have here. its refering to edta, i am looking at dmsa, what i discussed above is a derivative of mcp, which is pretty harmless but not as effective. the advocates of mcp claim more effective than edta without sides. i think its dangerous cancer.org has said what it its said.

so the assumption that heavy metal toxicity does cause an environment where cancer grows unchallenged by the bodies defences.

so should i leave the lead, mercury and arsenic in my body ? noway.

but if i followed their advice i would. noway.

as i said earlier somewhere the issue is that some of the world best treatment cancer centers want a clean hair test for heavy metals before they will admit you for treatment. the reasoning to me is clear, heavy metal poinoned patients don't survive.

the responsible apporach to this issue is to say heavy metal poisoning is bad. you should fixed it asap safely. many non toxic ways besides edta. i am not an expert on this and will know alot more after the conference on the weekend about this.

as you said let the buyer beware, as always.

i am just hoping that i am the only one the baord who is getting their heavy metal problem fixed as from what i researched mercury and lead screw your immune system.

when i goggled lead and mercury and immune
i got.
http://www.blacksmithinstitute.org/files/FileUpload/files/Environmental Contaminants and the Immune System.pdf

i found lots of good artlicles and no ads. i was lucky tonight.

so this study clearly shows how bad lead and mercury are for the immune system. now it sounds reasonable from my research. this was just done to prove that vaccines have issues with heavy metal poisoning.

anyone who wants to be a candidate for possible immuno therapy, well should read about the immune system and meavy metal toxity. its an easy and cheap thing to test for and resolve.

all i say is lets give our immune system a chance, that all i am trying to do. its better than folfox or chemo and if it works may help prevent their use.

so hello, our immune system is what protects us against cancer. its at the antigen stage that the battle is fought. i wished my onc warned me about this day one after surgery. maybe i would not be battling a possible recurrence now. this is just my view for my specific case based on my study and clinical history.

your response motivated me to do more research and learning.
thanks for caring.

pursuing health vigorously is my goal, not everyones cup of tea of course. thats the way it should be.

hugs,
pete

ps the answer to all my onc's questions about alternatives is simple.
does the absence of specific double blind clinical trials (evidence based medicine ) preclude commonsense. is pursing health and erring on the safe side not a valid course of action if a patient expresses a desire to do all that is possible to survive. this is my situation and i feel the onc's and the traditional medical establishment are negligent in their duty of care they have to me. sorry but i feel strongly that one day, and that is coming real soon i think the standard cancer treatment offered will be health based not radio/chemo focused.

pete43lost_at_sea said:

so i ordered the chelation complex and have been sent the powder
i am so disappointed as the mcp chelation is the soft option for chelation, at least it is supposed to bind the heavy metals.

I am emailing the ceo of pectasol to see what they think about the difference in effectiveness of the pectasol versus the pectasol chelation product.


http://www.lef.org/magazine/mag2009/mar2009_Modified-Citrus-Pectin-Fighting-Cancer-Metastasis-Heavy-Metal-Toxicities_01.htm?source=search&key=pectasol chelation


Life Extension Magazine March 2009

Fighting Cancer Metastasis and Heavy Metal Toxicities With Modified Citrus Pectin

By Joanne Nicholas

Despite billions of research dollars spent every year, cancer remains the second leading killer of Americans. One reason cancer is so lethal is its tendency to metastasize to essential organs throughout the body.

Certain malignancies (like brain tumors) kill by infiltrating into healthy tissues, but the vast majority of cancer deaths occur when tumor cells enter the blood and lymphatic systems and travel to the liver, lungs, bones, and other distant parts of the body.

Unfortunately, there have been few effective approaches to preventing cancer metastasis. The encouraging news is that a specialized fruit polysaccharide called modified citrus pectin has demonstrated unique properties in blocking cancer cell aggregation, adhesion, and metastasis.1

Clinical research shows that modified citrus pectin helps limit disease progression in men with advanced prostate cancer.2 In addition to its cancer-inhibiting effects, modified citrus pectin shows promise in chelating toxic heavy metals that can be so damaging to overall health.3

Here, we’ll explore how this novel compound offers such distinctive and protective effects.

What is Modified Citrus Pectin?

The American Cancer Society recommends that adults eat five servings of fruits and vegetables each day in order to help reduce cancer risk.4 One way to get some of the benefits of citrus fruits such as oranges and grapefruits is with modified citrus pectin.

Pectin is a naturally occurring substance found in the cell walls of most plants and especially concentrated in the peel and pulp of citrus fruits (lemons, limes, oranges, and grapefruits), plums, and apples. It was first identified in 1825, but home cooks had long used fruits with high levels of pectin in jams and marmalades because of their gelling properties. While pectin provides little nutritional content, this carbohydrate acts as a beneficial type of soluble dietary fiber.

Researchers attempted to find a process to alter pectin to create a food supplement that would allow the body to benefit from its various health-promoting properties. Recently, scientists have been able to use pH and temperature modifications to break down pectin’s long, branched chains of polysaccharides into shorter, unbranched lengths of soluble fiber molecules that dissolve easily in water. The result, modified citrus pectin (MCP), is a substance that is rich in galactose residues, which are easily processed by the digestive system and absorbed into the bloodstream.5 Scientists continue to refine MCP in their quest for a more active and effective agent.

Preventing Cancer Metastasis

Modified citrus pectin is thought to be useful in the prevention and treatment of metastatic cancer, especially in solid tumors like melanoma and cancers of the prostate, colon, and breast. Scientists believe that MCP works by inhibiting two key processes involved in cancer progression: angiogenesis and metastasis.6,7


Angiogenesis is the process in which cancer cells establish their own blood supply to fuel their growth. Metastasis occurs when cancer cells break away from the original tumor, enter the bloodstream or lymphatic system, and form a new tumor in a different organ or other parts of the body.8 Secondary or metastatic cancers often pose more life-threatening circumstances than the original tumor.

As scientists begin to decipher the process of how cells receive, interpret, and relay the signals that recruit them to form new tumors,9 they are focusing their attention on molecules called galactose-binding lectins, or galectins. Galectins are overexpressed adhesion and blood vessel-attracting surface molecules that are thought to be involved in the spread of cancer.6 A growing number of small studies in humans and animals have reported that MCP interferes with the cancer cell’s interactions with other cancer cells by acting as a galectin-3 antagonist—that is, an agent that blocks the normal activity of galectins.

Via the mechanism of galectin-3 antagonism, MCP appears to disrupt the processes that allow cancer cells to communicate with one another. When the MCP molecules bind to receptors on the surface of cancer cells, they block galectin-3 and other molecules from penetrating into nearby healthy tissue to create a new tumor and establish the tumor’s blood supply (angiogenesis). In this way, MCP seems to play a role in preventing cancerous tumors from metastasizing and spreading to other organs—one of the main causes of death from cancer.

When MCP interferes with cancer cells trying to form a new tumor, the cancer cells circulate in the bloodstream until they die. By working to inhibit the spread of cancer, MCP keeps the body’s immune system from becoming overwhelmed by an increasing cancer cell load.10

Modified Citrus Pectin’s Effects in Prostate Cancer

Prostate cancer is the most common cancer diagnosed in men in the United States. One in six American men will be diagnosed with prostate cancer during his lifetime. The American Cancer Society (ACS) estimates that 28,660 men die of prostate cancer annually, with only lung cancer more lethal to men.11 The ACS estimates a five-year survival rate of nearly 100% for men whose prostate cancer is diagnosed and treated at an early stage. But for those men with late stage, metastatic prostate cancer, the treatment options are very limited.


One of the first promising studies to show the potential of MCP to inhibit prostate cancer metastasis was published in the Journal of the National Cancer Institute in 1995. Laboratory rats were injected with human prostate cancer cells and divided into four groups. The control group received plain water and the other groups received water with varying concentrations of MCP. After 30 days, only 50% of the rats that drank water with MCP (0.1% weight/volume) had any metastases, while 94% of the rats that drank regular water had cancer metastasize to their lungs. The researchers called for further study to determine both “the role of galectin-3 in normal and cancerous prostate tissues” and “the ability of modified citrus pectin to inhibit human prostate metastasis in nude mice.”12

In 1999, Dr. Stephen Strum, an oncologist specializing in prostate cancer and a respected member of Life Extension’s Scientific Advisory Board, and his colleagues were the first to show the positive effects of MCP on humans with advanced prostate cancer. In a paper presented at an International Conference on Diet and Prevention of Cancer, they reported that five of seven men with advanced prostate cancer and unable to benefit from conventional treatment had a positive response after taking MCP every day for three months or longer. The response was measured by an increase in prostate-specific antigen doubling time (PSADT), which measures the rate at which blood levels of prostate-specific antigen (PSA) rise. Since PSA is a marker of prostate cancer progression or recurrence, longer PSA doubling time is associated with slower disease progression and is thus desirable. One of the five patients had no increase to his PSA level at all.13

A more recent study led by Brad Guess and Drs. Mark Scholz and Stephen Strum also found that MCP increases the PSA doubling time. In this phase II pilot study of 10 men whose prostate cancer had returned after an initial treatment with surgery or radiation, PSADT increased in eight (80%) of the 10 men after taking MCP for 12 months.14

Dr. Strum told Life Extension, “My clinical experience using MCP in prostate cancer has been that it slows PSA doubling time in the majority of patients taking the standard dose of 5 grams three times per day. Because this treatment is well tolerated, I use MCP in situations where sustained increases in PSA may occur.” In a study published in 2007, 49 patients with advanced prostate cancer and few treatment options were given oral doses of MCP powder diluted in water and juice three times a day at eight-hour intervals for a four-week cycle. After two cycles of treatment with MCP, 21% of the patients had a clinical benefit of disease stabilization or improved quality of life; 12% had stable disease for more than 24 weeks. One patient with stage IV metastatic prostate cancer showed a 50% decrease in serum PSA level after 16 weeks of treatment, improving his quality of life and also decreasing pain. “MCP seems to have positive impacts especially regarding clinical benefit and life quality for patients with far advanced solid tumors,” the researchers concluded.2

WHAT YOU NEED TO KNOW: MODIFIED CITRUS PECTIN
Pectin is a complex carbohydrate that is abundantly present in citrus fruits. Modified citrus pectin (MCP) is composed of short, non-branched carbohydrate chains derived from the peel and pulp of citrus fruits.

Compelling research suggests that modified citrus pectin may help block the growth and metastasis of solid tumors such as breast, colon, and prostate cancers.

Intriguing clinical studies suggest that supplementation with MCP stabilizes disease progression and lengthens PSA doubling times in men with prostate cancer.

Modified citrus pectin may represent a safe, non-toxic d of chelating toxic metals—without the need for intravenous infusions.

Supplementation with MCP has been shown to increase excretion of dangerous metals such as mercury, arsenic, lead, and cadmium—without removing essential minerals like calcium, magnesium, and zinc from the body.

A clinical study showed that supplementation with an MCP-alginate complex reduced total body toxic heavy metal burden in patients with a variety of health concerns.

MCP is considered safe and well tolerated. Dosages range from 6 to 30 grams per day in divided dosages; a typical dose is 5 grams three times daily.

Modified Citrus Pectin and Chelation

Beyond its benefits in fighting cancer metastasis, MCP may have applications in mitigating the health dangers posed by toxic heavy metals. Chelation therapy is a chemical process in which a substance is used to bind molecules, such as heavy metals or minerals, and hold them tightly so that they can be removed from a system, such as the body. Chelation can help rid the body of excess or toxic metals, but it is not known if this reduces artery disease risk. Chelation is used to treat lead and mercury poisoning.15,16

In most instances, chelation therapy involves the infusion of compounds via a catheter placed in an arm vein. This procedure must be done in a clinical setting over a specified course of treatments. In contrast, chelation therapy using MCP is done via the oral route and can be administered to the patient in almost any clinical setting, since the supplement can be ingested anywhere.


A pilot trial evaluating MCP’s chelating effects provided evidence that orally administered MCP significantly increases urinary excretion of toxic metals. In a study published in 2006, eight healthy individuals were given 15 grams of MCP daily for five days and 20 grams of MCP on day six. Twenty-four hour urine samples were collected on days one and six and analyzed for toxic and essential elements. The investigators reported that significant urinary excretion of arsenic, mercury, cadmium, and lead increased within one to six days of MCP treatment. There was a 150% increase in the excretion of cadmium and a 560% increase in lead excretion on day six.3 Essential minerals such as calcium, zinc, and magnesium were not seen to increase in the urine analysis, indicating that MCP treatment did not deplete these nutrients.

In a case study report, five patients with different illnesses were given MCP (PectaSol®) alone or as an MCP/alginate combination (PectaSol® Chelation Complex™) for up to seven months. Each one had a gradual decrease of total heavy metal burden, which is believed to have played an important role in the patients’ recovery and health maintenance. The patients had a 74% average decrease in toxic heavy metals after treatment. The authors report this is the “first known documentation of evidence” of a possible correlation of positive clinical outcomes and a reduction of toxic heavy metal load using MCP alone or as an MCP/alginate complex. They recommend “further studies be performed to confirm the effectiveness of this gentle non-toxic chelating system as an alternative to harsher chelators in the treatment of patients with a heavy metal body burden.”17

Lead toxicity is an ongoing concern worldwide, and the long-lasting effects of lead exposure in children are especially troubling. A 2008 pilot study at the Children’s Hospital of Zhejiang University, Hangzhou, China looked at whether MCP® could mitigate lead toxicity in children with high blood levels of lead. Seven children hospitalized with toxic lead levels, aged five to 12, were given 15 grams of MCP (PectaSol®) per day in three divided dosages. Blood serum and 24-hour urine excretion analysis were performed on days 0, 14, 21, and 28. Two patients were released after two weeks, three patients were released after three weeks, and two patients were released after four weeks when their blood lead levels had dropped below the criterion. All of the children had a significant increase in urinary excretion of lead. The authors recommend further studies to confirm the effectiveness and safety of MCP as a lead chelator.18

Scientists believe that the ability of MCP (PectaSol®) to chelate toxic metals arises from a low molecular weight pectin that contains 10% rhamnogalacturonan II molecular side groups, which are known to selectively bind heavy metals with a strong affinity. Subsequently, these metal–pectin complexes are eliminated in the urine.3

http://www.youtube.com/watch?v=5ahlawrQHeA&