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Not well enough for treatment

Posts: 81
Joined: Dec 2010

I went for my 2nd chemo infusion this morning to be told by the oncologist that there is a problem with my kidneys and my treatment will be postponed for a few days until the results of my blood tests are back. Also she seems to think I'm not fully recovered from an infection I'd had whilst in hospital a couple of weeks ago. I have to go back on Thursday and will see then if I can have chemo, either a different dose or perhaps a different chemo (I'm on carbo taxol at the moment). My CA125 level also seemed frighteningly high. On 22nd December when I first went for draining it was just over a 1000. By 31st Feb it had jumped to 2611. That seems an awful lot in just 6 weeks. I'm getting a bit (lot) worried here!

nancy591's picture
Posts: 1059
Joined: Sep 2009

Dont forget that inflammation can lead to a high ca125. Are you having any symptoms? I am still fighting my first recurrence and have been on chemo since January 2010. Most recently I've had huge ca125 jummps as well


Posts: 81
Joined: Dec 2010

Thanks for answering. The only symptoms I have are desperate thirst, mild nausea, constant trips to the toilet and excessive tiredness. I suppose more than anything I'm just scared I'm going to be taken off carbo/taxol because it worked so well for me before.

Posts: 81
Joined: Dec 2010

Is there any way to delete posts? This one went on twice. Don't know why

Hissy_Fitz's picture
Posts: 1869
Joined: Sep 2009

Sorry if I don't have the details down correctly, but it sounds like you were in remission for a year and are now being treated for your first recurrence, and have been prescribed Carbo/Taxol, the same combo you received as first line treatment. Is that right?

Any infection can cause a spike in your CA125, so I wouldn't worry too much about that. My CA125 at the time of my diagnosis was 4,000 and Leesa G's was 10,000 (she is such an over-achiever). Anyway, the CA125 number is not an indication of how much cancer you have.

Some of the chemo drugs are processed via the kidneys, so your doctor might indeed want to switch you to another one. There are plenty of them out there, so I'm sure they can find something that will zap the cancer, without killing off your vital organs. Sometimes that's a trick, in anc of itself. My doctor told me the idea is to pump enough poison in us to kill the cancer, but not so much that it kills the patient.

Let us know what your doctor says when you go back on Thursday.


Posts: 1223
Joined: Jun 2008

My kidney count was up (Creatinine - CRE normal should be 0.6 to 1.2 milligrams) early on in treatment. In my case there was a tumor pushing on the ureter (seen on the CT) causing a blockage and the kidney count to elevate. They put in a stent, I lost 6 liters of water immediately, and kidney began functioning. I still have a stent in (goes from the bladder to the kidney) and although the tumor is no longer there, an adhesion has developed and it is safer to just keep the stent in. I have had a lot of chemo and although they always check the CRE, it has remained stable, and not interferred with getting chemo.

My friend's kidney shut down evetually from a blockage on the ureter, but she continued receiving chemo with only one kidney functioning.

I hope that your kidney problem is something that can be resolved, and you can continue our carbo/taxol.

Take care,

Posts: 81
Joined: Dec 2010

I didn't get chemo after all. I had to have a CT scan, bloods tests etc. Apparently my blood work shows that my kidneys are improving and the scan shows several pockets of fluid which are pressing against my organs and what they think is a large cyst which is pressing against my bladder. I'm booked in for my carbo/taxol on Monday morning. Does anyone know whether delaying chemo for a week or so makes any difference to the outcome? I hope not

anicca's picture
Posts: 325
Joined: Dec 2010

I think delaying a week is not a problem. I asked to delay round 4 of 6 so I could have an extra week to go camping last summer, and was told 1 week was fine.

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