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folfox with 21 day cycle and xeloda

vinaykumar
Posts: 66
Joined: Dec 2012

my dad just started ( 4 days back ) on folfox 6 with 180 mg oxaliplatin infusion followed by 2X2 oral xeloda (500mg) tablets for 14 days and then a 7 day break. making it a 21 day cycle....

 

has anyone had this protocol ? please share your thoughts/experiences.

Chelsea71
Posts: 1170
Joined: Sep 2012

Not familiar with this regimen. How is he tolerating it so far?

vinaykumar
Posts: 66
Joined: Dec 2012

its been 4 days since it started....no major issue till now...he complains of slight bad taste in the mouth.

Chelsea71
Posts: 1170
Joined: Sep 2012

Hopefully he'll get through it easily and be able to enjoy life while being treated.

 

chelsea

Sundanceh's picture
Sundanceh
Posts: 4306
Joined: Jun 2009

Folfox with Xeloda or 5fu is pretty standard protocol.

The 14 on and 7 off strategy for Xeloda is also standard.  Only the dosage differs....I was doing 4000 mgs a day...

It got pretty toxic for me and my feet were a mess....so we switched to a 7 on and 7 off plan....if things get too intolerable, suggest this option....

The bad taste in his mouth is the "metallic" from the Oxy itself.

One other thing I could add was that if the cold sensitivity is being experienced when cool or cold drinks are tried...have the onc infuse Magnesium Sulfate...known as "The Mags." 

If it works, it will significantly reduce the cold sensations in the throat and make treatments more tolerable...usually for me it was about 7-days before I could drink anything cool...and the taste was altered, of course.

Mags makes it possible to drink cold liquids right out of infusion...a miracle if it works for you...but it does not for everyone...still, it's worth a try...and you'll know on the first dose, if it is going to be a benefit for you.

Your onc may dismiss this notion....press anyway...one time cannot hurt here....and may make a world of difference in the outlook of the patient in treatment. 

It's the little things like this that we miss...that cancer takes away...cancer is always about concession, concession, and concession.

The key for us is how much we can take back. 

Good luck!

-Craig

 

vinaykumar
Posts: 66
Joined: Dec 2012

thx...i shall ask my onc to add this....do you know if this one  21 day cycle = 2 folfox infusion based cycles? trying to calculate how many cycles my dad wd have

Coppercent
Posts: 143
Joined: Jan 2012

I did something similar and did well with it.  I had an oxy infusion and was on Xeloda for two weeks and took a break for one week.  I only did 2 treatments of it because I had just completed 6 of Folfox.  I always have done better with Xeloda than 5FU. 

vinaykumar
Posts: 66
Joined: Dec 2012

 

so is this one  21 day cycle = 2 folfox infusion based cycles?

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