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anyone else been asked for her2 receptor status to tailor chemo/antibody treatment

pete43lost_at_sea's picture
pete43lost_at_sea
Posts: 3915
Joined: Nov 2010

i got asked this today.
possibly something we should all know given that 11% of us can benefit from more effective treatments i suspect.

just curious ?

hugs,
Pete

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2648993/

Lovekitties's picture
Lovekitties
Posts: 2900
Joined: Jan 2010

The study paper you sent us to was published in January 2009.

Here is the conclusion of those doing the study:
____________________________________
Conclusion.

We have not demonstrated compelling evidence supporting a potential role for Herceptin in colorectal carcinoma as shown in breast cancer. Similarly we have not revealed that it is an important prognostic indicator. Some patients who overexpress HER-2 (11%) will respond to Herceptin. The evolution of signature genes in colorectal cancer and molecular profiling may facilitate identification of the small subset of patients overexpressing HER-2 who will have a favourable response to Herceptin therapy.
___________________________________

Given this conslusion, I doubt it is on the radar of most doctors. I would also suspect that given it's low sucess rate (only some of the 11%) with colorectal cancer the potential side effect I found on another site would cause most to side step it if other things are better suited. That is not to say there aren't riskes in all the "medical" treatment options.

__________________________________________________________

Perhaps the most important side effect to note is Herceptin's potential to cause severe cardiac problems, including heart failure.

____________________________________

Marie who loves kitties

pete43lost_at_sea's picture
pete43lost_at_sea
Posts: 3915
Joined: Nov 2010

your conclusions are correct based on the paper,
i have to apologise, the paper i put to explain the receptor background for colorectal,

so what new and available for me is another piggy back trifuntional antibody for her2,
that can be helpful for some colorectals.

so if i am her2 i get it. only one place on the planet, this antibody is still in testing.

i was curious if anyone else had been asked, i guess the answer is no.

this her2 antibody works with removab, its made by the same company. i would encourage patients to ask for their her2 status. you need to have your parrafin tumour slide reviewed. i hope i am positive her2. the immune sysytem needs all the help it can get.

hugs,
pete

pete43lost_at_sea's picture
pete43lost_at_sea
Posts: 3915
Joined: Nov 2010

i am so kind and loving, but a touch frustrated I cannot get either of my sydney oncologists to look up my her 2 status. I just need a + to have another effective antibody treatment.

I have posted this on my blog as well.

http://meeting.ascopubs.org/cgi/content/abstract/26/15_suppl/3071

its not enough that for 10 months my onc says go away and grow the tumour, now I ask them to get the slide reviewed for her2 status and it takes 9 days to get no answer. I have made a follow call and was promised. good service speaks for itself, so does poor service.

does someone fighting for survival deserve better service, after all, they only have to call the lab where the tissue is stored. I could probably call the lab myself, pretend to be doctor pete and get the answer myself, but its against my ethics. I will give them a few more days. but not even getting an email response from bell my sydney onc, that sux. everyday in the clinic costs, I feel better, i have got this off my chest and I found the link for the antibody study.

hugs,
Pete

Lovekitties's picture
Lovekitties
Posts: 2900
Joined: Jan 2010

Is it possible for one of the docs there at the clinic to call and make the request? Or to fax a request to your Aussie doc?

Some times another doc has more pull at getting things like this done than just the patient who is in the fight.

Hope you hear soon.

Hugs,

Marie who loves kitties

pete43lost_at_sea's picture
pete43lost_at_sea
Posts: 3915
Joined: Nov 2010

great suggestion, i will give it a try tomorrow.
hugs,
pete

Minnesotagirl
Posts: 141
Joined: Sep 2011

Just wanted to pop in and say "proud of you Pete". Keep the faith my friend and continue to give "c" a good kick in the butt! Although I don't post much, I still follow your storyline. Praying for you Pete and all on this board.

"Minnesotagirl"

pete43lost_at_sea's picture
pete43lost_at_sea
Posts: 3915
Joined: Nov 2010

some times prayers come when we really need them. just like tonight. thank you again!
godbless us all, and may all our lives be full of peace and love.

i know the c is cancer, but my prayer tonight is for continued courage. i miss my family so much, i know the german treatment idea is my responsibility, but often the reality is more challenging than the idea.

hugs,
pete

Minnesotagirl
Posts: 141
Joined: Sep 2011

So tonight I shall pray for continued courage for Pete. I will also pray for grace and mercy for you as well. I can't imagine how much your family must miss you...keep the faith Pete and above all stay strong and well.

"Minnesotagirl"

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