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Zytita and heart conditions

ralph.townsend1's picture
ralph.townsend1
Posts: 353
Joined: Feb 2012

The MD Anderson doctor in first of July, told me my Metastatic ilac node's had improved and that I needed to get heart check. I had told them of more chest pains, but did not think it was heart. So this last Friday I went to Heart place in Richardson Texas and sure enough he said my heart sound great, but with the diabeties and the cancer medicine plus the pains in the chest. Probably best to get the test, it will come back good the pains will go away. With two stents being 12 years old. Need to check.

I don't know, if I should talk about this on the Cancer site.

Samsungtech1
Posts: 350
Joined: Jan 2011

Ralph,
Are you exercising? This is important. I just have one stent and am sure more are coming. Problem is with the PCa. You get the treatments, and the side effects and do not exercise. When they put my stent in they put me in physical therapy. Are you eligible for this? It is just a suggestion.
Good luck.
I sent you an email but it came back.

Mike

ralph.townsend1's picture
ralph.townsend1
Posts: 353
Joined: Feb 2012

I was until the summer. The good thing is I have loss about 15 pounds sent Oct. 2011. I'm not exercising right now, but staying very active and eating better. I sent you the correct email address. Between the lupron and Zytiga I get very tired and hot flash to death.

hopeful and opt...
Posts: 1335
Joined: Apr 2009

There are various posts at this site about diet. Basically a heart health diet is good for the heart(there are studies done that eating a veggie diet, avoiding stress, and exercising will reverse conditions of heart disease, fight diabetics, cancer, and is good for pretty much everything else. There is a Dr. Ornish who several years ago wrote a book "reversing heart disease" that talks to this. During the last few years he has been doing research to determine the effects on PSA from patients using his life style regiment. This has shown decreases in PSA among a small sample of patients .

There is a dvd FORKSoverKNIVES that discusses life style changes. Some of us have at this site have seen this video and have made positive changes resulting from information gained from the video.

There is a book, called "The China Study" by T. Collin Campbell which the above dvd is based on which in my opinion is the bible of eating properly.

I for one have made life style changes based on the above. My blood numbers are better, cholesterol, etc, my weight is down,have lot's of energy, etc, etc. I feel that I am a warrior fight this beast. Others at this site have also made life style change and have seen positive results; two that I know of from their posts, and who are a lot smarter than me, are Swingshift Worker and Kongo.

Enjoy the moments of life

Samsungtech1
Posts: 350
Joined: Jan 2011

Unfortunately Ralphhas Ischemic heart disease. Agent Orange is a bad disease. There are over 14 different things you can get, and they can just keep coming. You do not need to just beat one disease they just keep coming. Heart healthy is good. No matter what it will definetly help. Thanks for the input.

ralph.townsend1's picture
ralph.townsend1
Posts: 353
Joined: Feb 2012

Yes I have IHD and I wish I didn't have it, but Peripheral Neuropathy do to the diabeties II. The diabeties flared up because of the cancer medicine I was on last year. I can't walk further than 20 feet without burning pain and shocking pain in the legs. The arms and hands do the same thing. I see the Neuro-Oncology doctor's at MD Anderson and along with a Clinical Dietitian. Since Oct. 2011 I have lost 15 pounds and was walking in May 2012 until the PN came back. My diabetes is under control with medicine for now. I don't think the Zytiga is causing this new problem with PN.

VascodaGama's picture
VascodaGama
Posts: 1573
Joined: Nov 2010

Ralph

I wonder if you got any results from your last check up on heart health. Your comments above on symptoms are worrisome. Zytiga main effects concern hhypertension, hypokalemia, and fluid retention and such could be influencing some of those symptoms. Chest pain and fast heartbeat may signal an “overheat” from the drug. Lupron may also be causing you weakness, or cramping when walking. In any case the best way to counter the effects is by exercising, if you manage to do it.

I hope that you are now feeling better and that your doctor has given you good advice on what to do. Proper nutrition is important when taking drugs like Zytiga. I hope the lost in weight is under due “management”.
You could discuss with the doctor about any possibility in taking Zytiga intermittently. It would give you time to recuperate from the drug’s side effects.

Wishing you well.
VGama

ralph.townsend1's picture
ralph.townsend1
Posts: 353
Joined: Feb 2012

Back last year I had a Colonoscopy 11/2011, because of bleeding on and off. They discover that i had permament nerve damage to the rectal area call radiation proctitis. The doctor said i would probably never have complete control. VA also ran test last year and came back with 60% disablity for Bowel Incontinence due to radiation proctitis associated with Prostate Cancer. I'm now 400% disability with VA, but only 100% Permanent and Total disability.

I get to look it my blood test from MD Anderson. I looks like all the number's are going to the RED. They are not in margin, but the doctor's seem to be ok with them. VGama I think that the Zytiga is working fine, but i do agree that the Lupron is apart of the problem, I'm will Email the doctor about going off lupron. My next shot is in Sept 19,2012. I will let y'all know about my stress test which is monday. Father and Grandfather both die from aneurysm of the heart, but both were a lot old than me. They will be checking for that also.

On a funny note is that VA has me rated with all these condition's, but will not give me my rating for depression and Hypertenion. Do they know that I'm on the edge. How can they say it is not service connected?

Samsungtech1
Posts: 350
Joined: Jan 2011

Ralph,
I know they increase disabiliy for loss of organs, but once you reach 100 percent how much higher can you go? Buddy of mine has been waiting two years for them to declare him 100 per cent finally gave it to him. What is above 100 per cent?

Mike

Samsungtech1
Posts: 350
Joined: Jan 2011

Ralph,
I know they increase disabiliy for loss of organs, but once you reach 100 percent how much higher can you go? Buddy of mine has been waiting two years for them to declare him 100 per cent finally gave it to him. What is above 100 per cent?

Mike

ralph.townsend1's picture
ralph.townsend1
Posts: 353
Joined: Feb 2012

Its means nothing, once your 100% P&T permanent and total disability the other percentage mean nothing. You can be 100% and not P&T.I'm

100% prostate cancer
100% lymph node cancer
20% diabetesII
10% heart disease
60% peripheral Neurophathy left leg
40% peripheral Neurophathy right leg
10% peripheral neurophathy right and left arms
60% bowel incontinence
_____+ SMC loss of organ and home bound!
that equals = 100% P&T and some of the condition's have got worst!

Vgama, if I could solve the problem with the Perpheral Neurophathy, I think I could get back to full time of exercise. About 20 to 30 feet is my max right now, and if don't take my lyrica of 300 mg twice a day my body go into a rage. The specialist at MD Anderson they are trying to keep me on a good diet.

As you can see, that It's hard to care about the PC. I'm tired, y'all stay strong and God bless!!!!

Samsungtech1
Posts: 350
Joined: Jan 2011

Ralph,
I get 30 per cent for PTSD, it really does not make a difference. Like you said 100 is 100. I am sorry the neuropathy is causing you so much trouble. Hopefully they can give you some help. I have a friend from VN and he is in a wheelchair from this. Keep the faith brother, you are in my thoughts.

Mike

Samsungtech1
Posts: 350
Joined: Jan 2011

Ralph,
You know there were probably times when you thought you might not live another minute. Hard to explain that feeling, but we got past that. This is the same thing except we are older and have alot more aches and pains. Think about what you felt then. What it felt like afterwards. You have never been so alive. Channel that feeling and use it to your benefit. Keep positive brother.

Mike

VascodaGama's picture
VascodaGama
Posts: 1573
Joined: Nov 2010

Ralph, My elder brother.

I and many comrades following your posts are grateful for the info you have been passing on. Though I never experienced the symptoms you got or even been close to someone with your status, I do understand how desperate the condition may be.
I sincerely wish you the strength needed to fight your diagnosis.

Lupron is known for mood changes and depression. It may be affecting you very much. My experience with Eligard (leuprolide acetate) in the initial stages was depressive at times and such cause me to cry. I knew about such side effect and so tried hard to overcome those depressing feelings.

I hope your doctor takes your wish into consideration and lets you out of Lupron for a period. In fact Zytiga does not require the patient to be in chemo castration. Hypogonadism may be causing many of your symptoms. However, participants in the trial may be obliged to take both drugs.
Take a copy of this video of Dr. Myers with regards to hormonal treatment, to your doctor if you think it good;
http://askdrmyers.wordpress.com/2011/10/05/male-hypogonadism-pca/

You are a fighter and I know you can overcome this harsh moment of your care. Keep it up, please.

Thanks for the previous message regarding the colonoscopy.
God bless you.
VG

ralph.townsend1's picture
ralph.townsend1
Posts: 353
Joined: Feb 2012

Well I been out of action since the first of August. Mid july I started having chest pains and other thing that is apart of having a heart attack like stomach, jaw, and back/shoulder pain. August the 6th I went and did a stress test and other test with no result- things were cool accept the pain. Two days later have pretty bad chest pains and now I get some Nitro. Three days later the next attack and off to ER. Stent number 3 August 17 2012. Continue the Zytiga and the PSA 0.3.

The last month real tired, but feeling better now :}

Samsungtech1
Posts: 350
Joined: Jan 2011

Ralph, bro

I am so sorry. I quit a couple of treatments because of side effects. My oncologists tells me I will probably die of heart attack before cancer can kill me. My heart has been hurting for a few weeks. Tired of going to doctors to hear them say take your pills. Anyhow brother I am really saddened bythis news. If the lupron is messing with you quit it. You do not have to ask, just tell them. See what happens after awhile. You feel better, go for it. Those Dr's are guessing as much as picking numbers for the lottery.
We both suffer from the same things. Mine is to the organs, but what difference does it make. If you really feel like it is the Lupron, and you sound like your not doing well, cut it out. Do not just do what they tell you. If that stuff is taking your energy then you need to cut it out and start getting your energy back. The less you move the more all these things win.
Please brother fight. Doctors are ok, but you are the only one who knows what is going on. You have to go with your judgment. Listen to your body and it will talk to you. if you feel the Lupron is causing these problems stop taking it for a few months. See if you improve.

Mike

Kongo's picture
Kongo
Posts: 1167
Joined: Mar 2010

As one Vietnam vet to another...hang in there Ralph. I know you're going through a tough time. We've both see worse. Keep your head down and your gun up. We all have more battles ahead of us and I know you will do great. Thinking of you.

K

VascodaGama's picture
VascodaGama
Posts: 1573
Joined: Nov 2010

Ralph

I am sorry to hear about the heart attack. I agree with Mike, give up with Lupron if such gives you the confidence of improvement. I wonder what your doctor has recommended. In any case you can stay out of agonists without causing any negative effect in the treatment. Zytiga and Lupron work differently and independently.
Zytiga avoids cells from manufacturing androgens. Lupron avoids signalling at the pituitary that controls the manufacture of testosterone at the testes.

As a veteran you have lots of experience in confronting difficult situations and now you need to become the one in control.
Do not give up but take a break.

Sending you the “force”.
Best wishes for an improvement.

VG

ralph.townsend1's picture
ralph.townsend1
Posts: 353
Joined: Feb 2012

Thanks Mike, Kongo, and VG,

I put in a call and Email to my MD Anderson doctor's about quiting Lupron and staying Zytiga for now. I got out late Saturday from the hospital and last night I started having after shock to the heart area. Took a nitro and went away, will call doctor today. He is one of the best in Dallas. What I can't understand is the stress test showed negative to any probrems. Every stress test and all the other test has never shown any thing. No more stress test and maybe no more heart doctor?

Oh the good news they added a new medicine called Plavix???? I wonder what it causes. Life is as a old Engineer told me. Everything has a cause and effect! Lupron, Zytiga, Lyica, ETC!

VascodaGama's picture
VascodaGama
Posts: 1573
Joined: Nov 2010

Ralph
If you mean Plavix (clopidogrel) this is a drug to prevent blood clots after a heart attack.
Just read this link for the side effects;
http://www.drugs.com/plavix.html

However, not to alarm you, I think it better to inform the doctor controlling Zytiga because it may interact with Prednisone.

Wishing you recover the soonest.

ralph.townsend1's picture
ralph.townsend1
Posts: 353
Joined: Feb 2012

My doctor at MDACC said NO WAY on quiting the lupron. Because of the Lupron shuting off the food to the cancer. The Zytiga would not work alone and I would see a increase in the psa and my tumors. MDACC said the heart condition was not associated with the Zytiga or Lupron. The Diabetes II even if it is under control, still he points the finger at it!

laserlight's picture
laserlight
Posts: 165
Joined: May 2012

Ralph; As one Vietnam Vet and Brother hang in there and take it easy.

Kurt

Samsungtech1
Posts: 350
Joined: Jan 2011

Ralph,
Have you researched the difference between Lupron and Zytiga? What is the difference? Also go back through your medications. Did they add a new one before the heart problems? I am going through the same thing. Been having pain in cheat, but because I started coughing up blood I figured me lung cancer was coming back. Onc sent me to heart doctor. Ekg today was normal, heart normal, so Thursday I get the neuclear stress test. My CT scans came back negative. Nodules still gone. So I have 911 on speed dial. Just waiting for it.
I do not care what any doctor tells you. It is your life. Figure outmwhen the pain started and then remember, good luck with this, My memory is gone, what pill theygave you. What good does it do if they save you from cancer but kill you with a heart attack?

Check all of it out Ralph. Trust your judgment.

Mike

ralph.townsend1's picture
ralph.townsend1
Posts: 353
Joined: Feb 2012

Guy's I'm fine, Going on my first of two vacation's this year. Have not been anywhere in 10 years. I hope the beaches are clothes optional.

Kurt and mike! its know big thing! I'm fine!!!@!

I see MDACC in six weeks and i will voice my concerns!!!!

PSA still at 0.3 so they must be doing something right!!!

God bless Y'all!!!!

:-)

ralph.townsend1's picture
ralph.townsend1
Posts: 353
Joined: Feb 2012

Vgama

As all drugs have side effect's. To say that the one's that I have are connected to the drug or any of the many drug's I take. Can cause Heart attack, so should I stop all drugs.

Samsungtech1
Posts: 350
Joined: Jan 2011

I worry about you, am following in your footsteps. I worry with drugs because they cause side effects that you have no way of knowing where they come from.

Sorry for the over reaction. There are only so many of us left. If we do not watch out for one another who will. My brother in law was apache gun ship pilot. He got 2 DFC's 4 purple hearts, a silver star, a bronze star with oak leaf clusters. He was that bad dude you never wanted to meet. Got shot down twice. Once when they lost all the helicopters in VN. He is a hero. Suffers from wounds, and broken bones from crashes, but still a presence.

We all need to take care of one another. No one else will.

Mike

VascodaGama's picture
VascodaGama
Posts: 1573
Joined: Nov 2010

Ralph

It is nice to read your posts again. And more than that, you seem to be alive and kicking. http://www.youtube.com/watch?v=ljIQo1OHkTI.

Your doctor may be right but I disagree with his reasoning. Lupron stops production of testosterone which is necessary to many functions in our body. The cancer may be starving but so are other vital systems that keep us alive. Patients with low levels of circulating testosterone in longer periods of time are at risk of heart attacks. One must think about priorities. Surely for your doctor it is more important to see successes in the treatment of prostate cancer (his responsible). As you comment the results in terms of PSA demonstrates exactly that.
However, another doctor may have tried to avoid the risks the treatment entails, and, at first sign of trouble, would alter protocols.
I am confident that Dr. Charles Myers would do just that.

In any case, instead of cutting on medications, doctors usually try to circumvent complications with the aid from other drugs firstly. Probably Plavix was chosen thinking in your protocol but you should inquire for any interaction between the drugs you are taking, and get adviced or the symptoms and on what to do if any goes wrong.
You got an example with the Prednisone that it is by itself already an aiding drug taken with the purposes to avoid any effect that Zytiga may cause to other body function.

Not all the drugs interact between them but many cannot be taken and are strictly prohibitive.

I am happy to know about your plans for the beach trip. Enjoy the bikinis and try to get not so excited. Have a good time.

Best.
VGama

ralph.townsend1's picture
ralph.townsend1
Posts: 353
Joined: Feb 2012

War is terrible! Your brother in law is a HERO! At four purple hearts they send them home, so he came home and he probably has some problem's, if not manying!

The drugs are doing fine, I just need a different Heart doctor! Mike YOU hang in there, and let us live history.

Samsungtech1
Posts: 350
Joined: Jan 2011

Ralph,
Going formuclear stress test for heart tomorrow. My onc was surprised I had not had test done before. Told him Dr. Told me you areon the table. We don't need any tests. LAD was blocked. Lucked out. Ihope you find a good Dr.

Good luck,

Mike

ralph.townsend1's picture
ralph.townsend1
Posts: 353
Joined: Feb 2012

Mike,

I hope I fine you safe and in good condition. You need to be check every year. My MDACC doctor said the best thing I should have is a strong heart to fight the Drugs and the Prostate cancer. The weather starting to cool off early in the morning and its time to get my walking shoes on!!! Since my stent, I'm feeling better.

God Bless and you take care

Ralph

Samsungtech1
Posts: 350
Joined: Jan 2011

Ralph,
Get results next week. Weird test. They inject you with drugs that feel like you have been kicked in the gut. Still have headache from it. They sat it stimulates a vigorous work out. I think I would have taken the treadle.

Texas walking? Good thing about walking in Texas is that you have to walk fast to keep your tennies from sticking to the sidewalk. Good luck with that. Is the temperature in the morning below 80 yet?

Good luck bro. Keep in touch.

Mike

ralph.townsend1's picture
ralph.townsend1
Posts: 353
Joined: Feb 2012

After my stent in mid August at a local hospital by my heart specialist. I started having chest pain about two days after and thought that it was the ghost pain. They continued so slowly over the three to get worst and went back to the heart specialist and he wanted to go back in. I said no first, but by last Sunday I went to the Heart hospital and do another Angioplasty. The specialist told me maybe heart burn, and I gave him the PTSD look. Anyway they went in and found nothing THEY said! It's been three days and I have not had one bit of pain????? I question these doctors cover up for the over doctor. Or I'm losing it.

I know this subject has nothing to do with PC, But the cancer medicine Zytiga might, or Diabetes II, or the Agent Orange. Pick one!!

Samsungtech1
Posts: 350
Joined: Jan 2011

Ralph,
Are you still having pain in your chest? Not sure from your post. I would read your med warning labels. Do not think you could have escaped side effects with all that is going on. Lost my right wrist today. Hurts bad enough for percocet. Not sure if it is cancer or arthertic effects from pills. Bad timing as my son and I are heading to Alaska next month to go trout fishing. Right wrist is crucile. I am going no matter what. World record for rainbow trout was 44 pounds. Plus steelhead are still there. Steelhead rock! Anyhow hopefully I will have enough body parts to fish.

I hope you get to the bottom of this. I still strongly suspect that you might be having aide effects. I,atpresent,am not having too many side effects. Ican feel my. Muscles shrinking, my leg muscles are retreating, my pot belly is hanging in there. I am now at 35 inch waist. I have about two inches of fat that does not want to go away. If it likes me that much I figure it should stay.

Take care brother,

Mike

ralph.townsend1's picture
ralph.townsend1
Posts: 353
Joined: Feb 2012

Oh, are you trying to make feel bad!!!

35 inch, you got to be joking! I have not seem a 35inches in 15 years.

Now a trout that 44 pounds is like seeing me at 35 inch waist line.

I hope you have a good trip. I heart is with you
.
God bless and be safe!!!!

tonybuxton
Posts: 78
Joined: May 2012

Mike I envy you. I wish I could afford to go trout fishing. I did a lot in New Zealand some years back. You are a fine example to all of us. In spite of all your medical problems you are doing the things you want to do and I hope you get a great big rainbow. My record was about 7 pounds but it was great eating.
Good luck
Tony

VascodaGama's picture
VascodaGama
Posts: 1573
Joined: Nov 2010

Great posts and great adventures from great patients of this forum. The 44 pounds, 35 inch and 81-sex affair made me laugh. A joke I heard and never forget from my times at the hospital was this;

During one of Prime Minister Tony Blair's visits to a Home for the elderly, he said to one woman, "Do you know who I am?"
She replied, "If you don't remember who you are, just go to the front desk and the nice lady at the reception will tell you."

And the good news;
After a virtual (CT) and an endoscopic examination of the colon (total colonoscopy) the Gastroenterologist diagnosed me with Diverticulosis. He commented this being an old men’s disease. He found several diverticula (bulging pockets) along the colon but did not find any scar from past radiation therapy (IMRT). At the time of the test there were no signs of bleeding so he thinks that my previous bleeding experience were due to an occasional diverticular bleeding or inner haemorrhoidal bleeding. Both do not usually cause pain (abdominal).

I am satisfied with the results and want to celebrate with a good Portuguese red. How about sharing with me a drink and a joke.

VGama

tonybuxton
Posts: 78
Joined: May 2012

Sorry Guys I sent a reply to mike instead of Ralf about trout fishing.
When I read about how you are suffering and dealing with your Pca problems I feel so lucky that at present I have none.
Re post about diverticulitis I don't think it is much to worry about. I have had it for years. It seems to come and go.
Good luck VGAma I wish I could join you for a glass of "Mateus Rose" My parents retired to the Algarve and when I visited I drank huge quantities of this wine at About Cts 75 a bottle then. Now I have to pay $20 so I can't afford it.
To Ralf the Zoladex (Lupron) did give me angina and diabetes. I never had it before and never again after I stopped.
Best to you all
Tony

Samsungtech1
Posts: 350
Joined: Jan 2011

Tony,
Our problems are just part of life. We deal with them as they come up. It's all good. We enjoy what we have. If we didn't have a sense of humor we would really have a hard time. Life is good. Trout fishing is an extra. Son came up with the idea. Works. It is beautiful up there and October is low tourist. Good time to go.

Vgama,
My mother-in-law has that. Main thing I heard was not toneat seeds. She has been doing that for years and all is good. I wish you well. When I lived in San Francisco, born there, Mateus really got popular. We use to pass it around till it was empty. Start on another one. I am sure we helped Portugals economy immensely.
I look forward to sharing some good wine with you next spring.

Mike

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