I wasn't able to get any copies of my study today. I'm going to get one on Wed when I get my avastin. Here is what I found out and my new strategy. I have two significant protein overexpressions.
I have the maximum overexpression of SPARC: secreted protein acidic and rich in cysteine. It is calcium binding macroprotein. Cells use it for wound repair. Tumor cells use it for angiogenesis. It collects and stores albumin. Clinical studies show that nab-paclitaxel (Abraxane) is very effective in tumors that overexpress SPARC. Abraxane is a 2nd line breast cancer therapy. Abraxane is a derivative of camptothesen, which is a naturally occuring microtubular agent. Microtubular agents limit cell division that often results in the cells death. Abraxane is delivered and transported into the cell via albumin. Which is probably why SPARC overexpression responds well to Abraxane.
I also have a maximum overexpression of PDGFR: platelet-derived growth factor. These growth factors bind to the protein tyrosine kinase which leads to changes in gene expression. The drug Imatinib inhibits PDGFR activation.
They are going to recheck me for BCRP overexpression: Breast Cancer Resistance Protein. They think I might also have the maximum overexpression of BCRP. If so, recent studies suggest that overepressions of both BCRP and SPARC result in very favorable responses to mytomycin-c. This drug was researched heavily a decade ago but was found to have very little benefit, though there were reports of a small number of significant positive responses. I may be one of those.
I will do two more cycles of Xeloda and avastin. After that I will be doing four cycles of Abraxane and avastin. I will then be scanned a hopefully the chemo along with the embolization will have worked well enough for me to have surgery to remove what ever may be left.
CarisDx Molecular Profiling Institute is the lab that did the work. They have many sites but their new lab is in Phoenix AZ. To learn more they have a website. CarisDx.com,
Last month I was told I would be on xeloda until it didn't work any more and that would be the end of my treatment. Today, I was given, three very good alternatives, all with 6-9 month progression free survival times. That along with a 6-9 month prognosis pushes my possible time to beyond two years. That's plenty of time for something new to come along. Hope is a powerful thing.