Genomics

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CheeseQueen57
CheeseQueen57 Member Posts: 933 Member
in Uterine/Endometrial Cancer #1

Not sure if there is a thread on here about genomics.  Apparently latest research shows that some high grade endometroid tumors have certain types of genomic alterations also found in serous tumors and may benefit from more aggressive treatment after surgery.  Plan to ask my surgeon to make sure genetic testing is done on my tissues.  My guess is that this is not routinely done (although may be done at Fox Chase).  Anyone have any input?

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  • Soup52
    Soup52 Member Posts: 908 Member
    #2
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    Genomics

    I have some interest in this also. I have two adult daughters and I would like to know if they have increased chances of developing this disease, especially my older daughter who I donated a kidney to 8 1/2 years ago.

  • CheeseQueen57
    CheeseQueen57 Member Posts: 933 Member
    #3
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    Soup52 said:

    Genomics

    I have some interest in this also. I have two adult daughters and I would like to know if they have increased chances of developing this disease, especially my older daughter who I donated a kidney to 8 1/2 years ago.

    Genomics-Possible impact on treatment decisions

    Yes Soup, that would be of great interest, also.

    But what I'm most interested in is the recent evidence that through genomic make-up, endometrial tumors can be reclassifed into distinct subtypes in addition to just pathology which may influence treatment decisions.  Remarkable was that about a quarter of high-grade endometrioid tumors have certain types of genomic alterations also found in uterine serous tumors which suggests that a significant portion of endometrioid tumors should be treated more aggressively after surgery.  Although I am  yet to have surgery, my tumor has been identified as high grade.  I plan to ask to have my tissues genetically anaylyzed for this reason.  Here are some articles:

    http://www.medpagetoday.com/HematologyOncology/OtherCancers/38791

    https://www.mskcc.org/press-releases/large-genomic-study-identifies-endometrial-subtypes-treatment-opportunities

    http://genome.wustl.edu/articles/detail/genomics-to-reshape-endometrial-cancer-treatment/

  • Kvdyson
    Kvdyson Member Posts: 789
    #4
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    Helomics Chemo Fx

    Hi CheeseQueen, my gyn-onc sent tumor tissue out for testing to see which chemo meds were most effective against it. The company doing the testing is Helomics and the test is called Chemo Fx. Although it is true that the testing is done in a lab-setting so who knows how well the results correlate to real life, it did give me peace of mind that the strong chemo meds that I would be receiving were somewhat "tailored" to give me the best chance of winning this battle.

  • Editgrl
    Editgrl Member Posts: 903 Member
    #5
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    Don't know why

    this isn't routinely done.  It seems like such a no-brainer, and perhaps in time, it will become routine.  My oncologist just referred me last week to the genetics department, and after my phone appointment today, they have decided to have my tumor tested.  There is quite a bit of cancer in my family, albeit everyone was diagnosed relatively late in life.  Depending on what they find, there may be more extensive testing.

    Chris

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