Nexavar Sorafenib questions please help

javier_garcia123
javier_garcia123 Member Posts: 28
edited August 2015 in Liver Cancer #1

I need to know how good is Nexavar (Sorafenib) at targeting RAF1 mutation, I ask this because Mom used Foundation One, have this mutation, and one of three Targeted Therapies recommended is Sorafenib, the other two being Regorafenib and Trametinib

 

The mutation is related to cell division pathway called the MAPK path: MAPK>RAS>RAF>MEK>CCNE1

 

Also, how to avoid as much as we can nausea? and if you can tell the most frequent side effects in practise and ways to avoid them

Primary cancer is unknown mucinous adenocarcinoma but Sorafenib is recommended, people use it on this forum, and there are five liver metastases, that's why the question here

 

Many thanks in advance for any help

Comments

  • aks3574
    aks3574 Member Posts: 10
    #2
    Nexavar, from what I know,

    Nexavar, from what I know, works for some. It stabilizes the tumour.

    My Mom has HCC and taknig Nexvar but it has not slowed down the tunour growth. Her AFP is coming down slowly..I am not sure what that means.

  • Mike5072
    Mike5072 Member Posts: 12
    #3
    Nexavar Use

    I was on Nexavar for about 10 months out of 14 months.  Started out on 400mg/day and worked up to 600mg/day.  The following is an excerpt from an email I sent to my doctors regarding how I felt taking Nexavar.

    "The fatigue is absolutely crushing, I have digestive tract issues every other day, my ability to focus and concentrate is impaired, my appetite has dropped, I am physically weak, my energy level is extremely low and my attitude is poor.  I would put my quality of life at 50% of what it normally is.  I have had to cancel business trips as I do not have the energy or strength to travel as I should.  My enjoyment of my personal life has been significantly reduced due to my fatigue, energy level  and poor attitude."

    The benefit was questionable so I opted to discontinued taking it.  Two TACE procedures have shrunk the HCC tumors I had and now the docs are deciding if I should have an RFA or Y-90 treatment on the remaining tumor mass.  The docs supported my decision, although I would have decided the same whether they agreed or not.  It becomes a personal choice.  Good luck.

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