Doxil Has Failed

Options
SIROD
SIROD Member Posts: 2,194 Member
edited September 2014 in Breast Cancer #1

Had a ct scan and echocardiagram yesterday.  I progressed in the left lung again, also have a small effusion and a fracture in the coracoid process (had to look that one up, had no idea what it was) it's a small bone in the shoulder.  I really thought it was a bout of bursitis as it seem like the same kind of pain.  I had bursitis back in 2011.  

I am sure that I will be off Doxil and on to the next.

I would really like a hormonal drug but it's probably to early to retry one, but I will ask.

Doris

«1

Comments

  • TraciInLA
    TraciInLA Member Posts: 1,994 Member
    #2
    Options
    F***!

    I have no words to respond to this news that can be printed here, or would be considered proper for a lady....

    All I have is a big hug for you, and know that we're all standing behind you as you start your new fight.

    Traci

     

     

  • Josie21
    Josie21 Member Posts: 382 Member
    #3
    Options
    Hi Doris

    I am so sorry that the Doxil has failed. I am sending you hugs and positive thoughts as you start your new fight against this horrible disease. I have every confidence that you are already gathering the information you need to fight back yet again.  You can do it!

    Hugs,

    Ginny

  • sbmly53
    sbmly53 Member Posts: 1,522
    #4
    Options
    Doris,

    ditto with Traci and Ginny. You are one of the strongest women on this board. You are amazing!

     

    Sue

  • camul
    camul Member Posts: 2,537
    #5
    Options
    Doris
    Sorry to hear that the Doxil isn't working. I hopr they can use another hormonal medication that will work. Hugs to you and please let us know what treatment they go to.
    Will keep the prayers going. Something must be working that is keeping us here.
    Hugs,
    Carol
  • New Flower
    New Flower Member Posts: 4,294
    #6
    Options
    camul said:

    Doris
    Sorry to hear that the Doxil isn't working. I hopr they can use another hormonal medication that will work. Hugs to you and please let us know what treatment they go to.
    Will keep the prayers going. Something must be working that is keeping us here.
    Hugs,
    Carol

    Doris I am really sorry

    I am really sorry, and like to repeat what Traci said.

     I hope youe oncologist and you will come to a new treatment option quicly. 

    I knpw what my next option will be Afinitor+Aromatisin.Afinitor has side effect, however pills are always easy than IV.

    Sending positive thoughts and hugs your way

  • Nana C.
    Nana C. Member Posts: 108
    #7
    Options
    Praying for you and sending

    Praying for you and sending you great big hugs. You are one of the strongest people I know also.  You lead in the fight for us all.  Thank you so much!

     

    In God we Trust

    Nana

  • hope67
    hope67 Member Posts: 181
    #8
    Options
    Doris, I am sorry about the news

    I can only imagine how hard it must be when another drug fails. But you seem so strong and focused. I am thinking about you and hoping that your oncologist finds a working plan for you.

    Hugs, Carmen

  • disneyfan2008
    disneyfan2008 Member Posts: 6,583 Member
    #9
    Options
    Hugs

    Hugs

  • CypressCynthia
    CypressCynthia Member Posts: 4,014 Member
    #10
    Options
    Oh Doris, I am so very sorry

    Oh Doris, I am so very sorry to hear this. OK, I think we both need a new pair of boxing gloves. I was just thinking the same thing- wouldn't a little hormone therapy be nice. Sigh. But you and I are going to kick some cancer butt no matter what they throw our way!!! 

  • SIROD
    SIROD Member Posts: 2,194 Member
    #11
    Options
    TraciInLA said:

    F***!

    I have no words to respond to this news that can be printed here, or would be considered proper for a lady....

    All I have is a big hug for you, and know that we're all standing behind you as you start your new fight.

    Traci

     

     

    Word

    Yesterday, I called my cancer center and told them to print out a copy of the results.  My oncology nurse offered to call me with the news of the report.  I had a feeling the news wasn't going to be good.  I rather read it myself than have someone inform of the news.  I read it, in the parking lot where no one would notice me.  

    The first word in my mind was "oh, f..."  -  I never use that word but it seemed appropriate to think it yesterday.  I then folded the sheets and drove home.  

    Thank you Traci for the encouragement as I try another chemo.

    Best,

    Doris

  • SIROD
    SIROD Member Posts: 2,194 Member
    #12
    Options
    Josie21 said:

    Hi Doris

    I am so sorry that the Doxil has failed. I am sending you hugs and positive thoughts as you start your new fight against this horrible disease. I have every confidence that you are already gathering the information you need to fight back yet again.  You can do it!

    Hugs,

    Ginny

    Xeloda it might be

    Thank you, Ginny for the hugs and positive thoughts.  I haven't started to look at what might be next.  I think there is a file on my computer for Xeloda which is what my oncologist wanted me on instead of Doxil.   Xeloda didn't mix well with folic acid which I use for the Methotrexate that I take for my uveitis.  The docs had a talk and reduced the Methotrexate so I probably have no excuse this time around.

    Hugs,

    Doris

  • SIROD
    SIROD Member Posts: 2,194 Member
    #13
    Options
    CypressCynthia said:

    Oh Doris, I am so very sorry

    Oh Doris, I am so very sorry to hear this. OK, I think we both need a new pair of boxing gloves. I was just thinking the same thing- wouldn't a little hormone therapy be nice. Sigh. But you and I are going to kick some cancer butt no matter what they throw our way!!! 

    New Boxing Gloves

    Dear CC,

    Hormone therapy would be really nice and I would never complain this around of bone pain.  I will sigh with you.  We will kick cancer butt this time and I am ready to fight again.

     

     

  • GlowMore
    GlowMore Member Posts: 789 Member
    #14
    Options
    Sorry

    Sorry to hear of your bad news about that drug.   After reading your page Doris you must be one tough gal to have been dealing with this thing for so long....what do you think has been the key to your endurance?

    I have been on the 'watch list' for too about 11 years but so far haven't had the dreaded recurrance, and about the only thing I can say about it is I just had to let go of the Fear at the beginning and just deal with the test and scans and endless blood work as it came and as it comes now.  But to have to be in constant treatment and to face all the various side effects of whatever new thing they throw at you.....it is amazing to me to read what some of you women have gone thru and are going thru and you still seem to be relatively strong and sane.         Sending Hope and Hugs and Encouragement ....and a great deal of Respect for your Bravery.  

    Glo

  • SIROD
    SIROD Member Posts: 2,194 Member
    #15
    Options
    New Flower said:

    Doris I am really sorry

    I am really sorry, and like to repeat what Traci said.

     I hope youe oncologist and you will come to a new treatment option quicly. 

    I knpw what my next option will be Afinitor+Aromatisin.Afinitor has side effect, however pills are always easy than IV.

    Sending positive thoughts and hugs your way

    For New Flower:

    Dear New Flower,

    I am pretty certain the oncologist will mention Xeloda as he did the last time.  I asked for

    Doxil.  It did give me the mouth sores and lower dose was fairly easy to do.  I had really

    hoped that I was stable to continue to take it.  As they say, "the devil you know is better 

    than the one you don't know".  

    Thank you for the positive thoughts.

    Doris 

  • SIROD
    SIROD Member Posts: 2,194 Member
    #16
    Options
    camul said:

    Doris
    Sorry to hear that the Doxil isn't working. I hopr they can use another hormonal medication that will work. Hugs to you and please let us know what treatment they go to.
    Will keep the prayers going. Something must be working that is keeping us here.
    Hugs,
    Carol

    For Carol:

    I used every hormonal there was except Aromasin.  I am waiting for the proper time to use it with Afinitor.  It hasn't been 2 years yet since Faslodex failed me.  I want to give it at least 3 years.  How is Aromasin doing for you?

    I wish that the FDA would approve Palbociclib (PD 0332991) which is now in trial in Phase III.  I read good things about it.  This one is for us with advanced bc.

    Carol, since you have bone mets, did you have fractures?  I don't remember doing anything to my shoulder that would have caused a fracture.  Unlike when I was on Arimidex and had 3 fractures in the vertebrae from a fall on ice.

    Best to you,

    Doris

     

  • SIROD
    SIROD Member Posts: 2,194 Member
    #17
    Options
    hope67 said:

    Doris, I am sorry about the news

    I can only imagine how hard it must be when another drug fails. But you seem so strong and focused. I am thinking about you and hoping that your oncologist finds a working plan for you.

    Hugs, Carmen

    For Sue, Nana and Carmen, Denise

    Thank you, Sue, Nana, Carmen and Denise for your thoughts and prayers.  I appreciate them as I go on towards my 3rd chemo.

    Best,

    Doris

  • SIROD
    SIROD Member Posts: 2,194 Member
    #18
    Options
    GlowMore said:

    Sorry

    Sorry to hear of your bad news about that drug.   After reading your page Doris you must be one tough gal to have been dealing with this thing for so long....what do you think has been the key to your endurance?

    I have been on the 'watch list' for too about 11 years but so far haven't had the dreaded recurrance, and about the only thing I can say about it is I just had to let go of the Fear at the beginning and just deal with the test and scans and endless blood work as it came and as it comes now.  But to have to be in constant treatment and to face all the various side effects of whatever new thing they throw at you.....it is amazing to me to read what some of you women have gone thru and are going thru and you still seem to be relatively strong and sane.         Sending Hope and Hugs and Encouragement ....and a great deal of Respect for your Bravery.  

    Glo

    For Glo

    Dear Glo,

    You ask what was "the key to my endurance".    One is that I had a slow growing cancer that responded well to hormonal therapy.  In August, I past my 20th year since I was diagnosed and I have had treatment all those years along with visits to my oncologist.  I had 18 years of using only hormonal therapies and I ran out except for that one Aromasin.  I hope to use it one day with Afinitor.  I am waiting for those cancer cells to forget all about hormonal therapies, so they won't turn off the drug.

    I do hope you always remain cancer free.  Remember for 70% of women who were diagnosed with breast cancer, it never comes back.  If only they could figure out something for the 30% group that did have it return as stage IV, then the puzzle would be solved.

    Best to you,

    Doris

  • GlowMore
    GlowMore Member Posts: 789 Member
    #19
    Options
    SIROD said:

    For Glo

    Dear Glo,

    You ask what was "the key to my endurance".    One is that I had a slow growing cancer that responded well to hormonal therapy.  In August, I past my 20th year since I was diagnosed and I have had treatment all those years along with visits to my oncologist.  I had 18 years of using only hormonal therapies and I ran out except for that one Aromasin.  I hope to use it one day with Afinitor.  I am waiting for those cancer cells to forget all about hormonal therapies, so they won't turn off the drug.

    I do hope you always remain cancer free.  Remember for 70% of women who were diagnosed with breast cancer, it never comes back.  If only they could figure out something for the 30% group that did have it return as stage IV, then the puzzle would be solved.

    Best to you,

    Doris

    TWENTY YEARS....

    Highly doubtful if I will reach 20 years since I am now 78 and at 12 years from Diagnosis.  How you have done it all this time and remained sane is a testiment to courage if you ask me.   I would never be able to use hormonal therapy...mine is the Triple Negative kind.......and to tell the truth at my age I am not at all sure I would do chemo again, but I can't say I wouldn't...it is just that the chemo almost kills you and I'm not as strong now as I was 12 years ago.  I love your picture ...it looks like the Pacific Coast...... I once lived in San Francisco and so loved it there.   Thanks for the good wishes.........my tumor markers came back a little elevated this week but I may not have to worry about it for another few months and then do another CA 27-29    ........    For me the endurance comes from my belief in Miracles...and firm conviction that God is Good...........He puts us where we need to be .....most of the time.   Hope you have a peaceful weekend....  :)  Hugs, Glo

  • aisling8
    aisling8 Member Posts: 1,627 Member
    #20
    Options
    GlowMore said:

    TWENTY YEARS....

    Highly doubtful if I will reach 20 years since I am now 78 and at 12 years from Diagnosis.  How you have done it all this time and remained sane is a testiment to courage if you ask me.   I would never be able to use hormonal therapy...mine is the Triple Negative kind.......and to tell the truth at my age I am not at all sure I would do chemo again, but I can't say I wouldn't...it is just that the chemo almost kills you and I'm not as strong now as I was 12 years ago.  I love your picture ...it looks like the Pacific Coast...... I once lived in San Francisco and so loved it there.   Thanks for the good wishes.........my tumor markers came back a little elevated this week but I may not have to worry about it for another few months and then do another CA 27-29    ........    For me the endurance comes from my belief in Miracles...and firm conviction that God is Good...........He puts us where we need to be .....most of the time.   Hope you have a peaceful weekend....  :)  Hugs, Glo

    I agree with the F asterisks word

    It's just so devastating to know it didn't work. You've been so valiant and uncomplaining. Makes me want to kick something when I read your post.

    i hane no doubt you'll rally and give another drug your all. I just didn't want you to have to.

    Sending hugs and good thoughts coast to coast.

    xoxo

    Victoria

  • New Flower
    New Flower Member Posts: 4,294
    #21
    Options
    SIROD said:

    For New Flower:

    Dear New Flower,

    I am pretty certain the oncologist will mention Xeloda as he did the last time.  I asked for

    Doxil.  It did give me the mouth sores and lower dose was fairly easy to do.  I had really

    hoped that I was stable to continue to take it.  As they say, "the devil you know is better 

    than the one you don't know".  

    Thank you for the positive thoughts.

    Doris 

    Hi Doris

    I am not sure if you remember, I was on xeloda for 8 months. I am a big fan of this medication. It did help me alot.

    Let me know if you decide to start. I will email you some useful tips.

    Hugs

Discussion Boards