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malignant fibrous histiocytoma (undifferentiated pleomorphic sarcoma)

Posts: 7
Joined: Jan 2014

My mom had a 14x9cm MFH sarcoma removed from her hip in June 2012.  After 36 radiation treatments and multiple complications including having to wear a wound vac for over 4 months, then wet-to-dry dressings, last CT in September showed mets to lungs...aggressive mets to lungs.  Chemo started same month, last CT showed no more growth but minimal shrinkage of tumors.  Waiting on results of last CT which we will receive tomorrow.  I am finding it extremely difficult to obtain ANY information or blogs recounting personal stories for this type of cancer with metastasis.  People post, then there is no continuation which is extremely disturbing to me.  To anyone who is reading this, I am asking to hear from you.  The information I am finding recounts an abysmal prognosis.  My mom has the idea that she is going to beat this, however I am a registered nurse and am quietly and sadly nowhere near as optimistic.  FYI: after chemo started, her wound opened back up and granulation of tissue halted.

ISurvivedCancer's picture
Posts: 2
Joined: Jan 2014

Hi lmcraig


your Mom's first defense is she going to beat it.  "Beating it" may be a few months or years.  No matter how long she beats it, it will be her victory.   You may find support at the following websites:





Posts: 7
Joined: Jan 2014

Thank you ISurvived...hope you are doing well

Posts: 8
Joined: Dec 2014

STORIFORM PLEOMORPHIC TYPE), HIGH GRADE SARCOMA, GRADE 3/3,  it needs to say "With Giant Cells" at the end.  this cancer is rare of the rare.


I have have found only three studies worldwide that covers "With Giant Cells" 100% mortality due to the tumor size, meaning that by the time it was removed it had allready spread.  The study size was small  20,24,27 people  as compaired to 2,387.


I have a list of sites that give prognosis estimates, but unless the cell types are matched up then not much use to you.


gross cut surface. Morphologically, this tumor involves skeletal muscle
and is composed of markedly pleomorphic and spindle tumor giant cells and
focal histiocytoid cells, brisk mitotic activity (> 20/10 per high-power
field) including atypical forms and geographic necrosis. The stroma is
mostly collagenized. There is a mild lymphoid response to tumor. Vascular
invasion appears to be present or possibly pushed into on slide 3. No
osteoid is observed. Surgical margins are clear. Immunohistochemical
stains on paraffin-embedded tissue demonstrate the tumor cells are
negative for SMA, desmin, C34, pankeratin, CK18, CK 56, and S100 protein;  = sarcoma  to most doctors

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