Jan 13, 2014 - 9:08 am
My friend Tim is two years post RP and IMRT. Age is 53, Gleason 9, PSA 22, 12/12 positive, EPE, SVI and PNI. RP was non-nerve sparing which included 12 lymph nodes which showed no cancer however he is most likely metastatic.
He now has a PSA of .5 which has been rising from the .1 range for about one year now. His PSADT is 4.5 months and Fox Chase Cancer Center wants him to wait until he is 2.0 to get him into a Phase III study involving Prostvac. I have suggested to him to begin HDT now..... My thoughts are why wait and let a cancer progress so you can enter a trial which you only have a 50 percent chance of getting a drug and.... according to my research can give you 4.5 months extended "time to progression" of his desease. This seems to me that allowing a tumor to form is pretty risky to meet the minimums for acceptance into a trial. If he can buy a year or two of remission with HDT perhaps then other treatments will be available should his desease becomes refractory and it most likely will.
Is my logic correct? I look at this trial as their final steps to bringing this drug to market. It is not curative.