Dec 18, 2013 - 2:21 pm
Haven't been on the forum for awhile and for those of you unfamiliar with my saga, here's a summary of my story.
I received CK treatment for my Gleason 6 PCa in Sept 2010 at UCSF. It took forever for my PSA levels to drop and it actually rose to 5.07 (higher than my PSA of 4.5 at biopsy) in June 2011 until it dropped to 1.55 in March 2012 but then rose 2 times from there to 2.12 in Sep 2012 (2 years following treatment), which was apparently just a classic radiation treatment "bounce", but concerned me and my RO enough at the time to get an MRI/MRSI scan done in Oct 2012, which was entirely negative for any evidence of cancer in the prostate. My PSA finally dropped below 1 (a primary indicator of treatment success) this past June but just barely so at 0.995.
I just took another PSA test yesterday and ther result came back at 0.624. So, although a reading of less than .5 would be better, I don't think that I've reached my nadir yet and I'm NOW reasonably confident (three years later) that the treatment was a success and that my cancer is currently in remission. Later tests will determine if that's the case or not. Here's hoping that you all have similar outcomes regardless of the treatment method you choose.
For those interested, here's a link to an abstract of a study that concludes that a nadir of .5 or less for post-radiation patients is a better indicator of survival than at .6. At .5, the 5 and 10 yr survival results were 95% (+/- 4%) and 84% (+/- 12%) respectively but between .6 and 1, the 5 yr survival rate drops to just 29% (+/- 30% which is an extremely high degree of error); the 10 yr survival rate for this group was not mentioned. And, at over 1, all treatments ultimately failed. The author estimated that 80% of the patients in the study would ultimately achieve a nadir of .5 or less and that 90% of those patients would be able to achieve nadir w/in 48 months of treatment, so I have a bit more time to see if my PSA will drop below .5. See: http://jco.ascopubs.org/content/14/11/2893.abstract
Wishing you all a Merry Xmas and Happy New Year!!!