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Axitinib / Inlyta

GSRon's picture
GSRon
Posts: 1175
Joined: Jan 2013

Hi All..  OK, so I am creating a new topic for just those that have any info on Inlyta - Axitinib.  I began Votrient in March, 2013, and stopped it due to Liver issues in July, 2013.  I started the Inlyta on 9-5-13.  Here it is less than two days later and my B.P. this morning was 162 / 100.  I should say that I anticpated the B.P. rise and took a 5 MG Norvasc on top of my 50 MG Metorprolol.  Two hours later, I am only down to 157 / 94.  I will check it again about every two hours.  

For me, I get a headache with high B.P. and so far this is the only side effect, but I know it is too soon to really report on much.  More to follow..

Ron

GSRon's picture
GSRon
Posts: 1175
Joined: Jan 2013

Yo Nano guy... good luck, but I am betting you get good results..!  See you in Sunny Eggo..!

Ron

garym's picture
garym
Posts: 1651
Joined: Nov 2009

Leggo my EggoWink

NanoSecond's picture
NanoSecond
Posts: 515
Joined: Oct 2012

Looking forward to it Ron!

But I am right coast guy.  So is that how San Diego is pronounced out there?  I've got a lot to learn and so little time...

Thanks for the words of encouragement.  I find Inlyta to be a very strange drug.  I have no idea if it is working on my liver mets but, unlike Sutent, it clearly was not controlling my bone mets.  At least it wasn't at the 5mg x2 dosage.  So I am a bit pessimistic.  Anyway, I'll find out soon enough.

GSRon's picture
GSRon
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Joined: Jan 2013

Neil, good luck on the scans..   OK, I looked at the revised Advocate/Patient schedule..  They are going to work my you know what off..!  It starts early morning and goes to late night.!  There is a lot going on there for sure..!  

Later..

Ron

NanoSecond's picture
NanoSecond
Posts: 515
Joined: Oct 2012

Well now you know why I decided to pay my way.  Believe me, it is totally impossible for anyone to digest this conference in one pass.  Every single day there are multiple sessions going on all at the same time and starting some days as early as 7am and some days going past 9pm.  It is lunacy.  The only solution is to choose which you will attend as best you can and then watch everything else that was missed after the conference is ended (via Internet access for the next several months).  In fact I still haven't finished viewing all the sessions from last year...

I do hope you and I get a chance to share a dinner or two though...

DMike's picture
DMike
Posts: 237
Joined: Nov 2011

Good luck tomorrow Neil!

David

NanoSecond's picture
NanoSecond
Posts: 515
Joined: Oct 2012

Thanks David.  About to depart in 5 minutes...

a_oaklee
Posts: 152
Joined: Nov 2013

Hey Neil,  I wanted to add my good luck wishes too! 

And of course, ask a question....does anyone know how soon a medication is supposed to show some effect?  And does it differ from med to med?    My husband originally took Pazo.. for 6 weeks and because of no response at the 6 week mark he was switched to Affinitor.  I remember wondering if they gave it enough time to work.

GSRon's picture
GSRon
Posts: 1175
Joined: Jan 2013

Yes Neil, we will meet up... I will have my cell phone..!  

Ron

sblairc's picture
sblairc
Posts: 74
Joined: Feb 2014

Hope you guys have fun! San Diego is the best place to live EVER. From the skylight in my classroom I can tell the weather isn't glorious today but give it a minute and I bet it will be. Enjoy the conference. 

NanoSecond's picture
NanoSecond
Posts: 515
Joined: Oct 2012

Great question.  But I not aware that there is any published suggested time frame for these various meds to start working.  What seems to be common is to wait anywhere from one month to three after changing before undergoing the next set of CT scans to see what the results are.

I can say that my personal experience taking Sutent is that it went to work within about a week.  That is to say, my bone met pain disappeared about one week after I first started taking it.  But that was at a point in time where all I had to deal with were bone mets which generated pain when not controlled.

But now I have no idea how to judge Inlyta since I am also relying on it to control liver mets - which are not painful at all.

GSRon's picture
GSRon
Posts: 1175
Joined: Jan 2013

Neil, all I can do is give you my experience..  Shrinkage was noted at 90 days.  My largest lung Met was like 9cm and it is below 8cm.  The next largest is about half size.  Some of the small ones are tiny.  Zero complaints here..!   Seems like small soft tissue Mets are not noticed.  I just looked at my last summer scan and it scared me..!  But I never knew they were there without the scans.

Ron

GSRon's picture
GSRon
Posts: 1175
Joined: Jan 2013

Minor info.. not sure it matters but..  I just got my new supply of Inlyta..  And I noticed the price went up to my insurance company.. then I got out all my prior bills and sure enough, as of Jan 1 the cost went up.  But, my co-pay stayed the same..  I feel so lucky to have such greart health insurance.. they never hassle me, always pay fast, and try to be helpful..

Be Well All..!!!

Ron

a_oaklee
Posts: 152
Joined: Nov 2013

My husbands bone mets also shrunk by about 1/2 after the first three months, and by the next 3 month period we were given the report of no metabolic activity seen. 

I remember reading on (the website before smart patients got created, can't remember the name of the site)....that some people thought a medicine was NOT working unless they had side-effects.  I personally do not agree with that measure of whether or not a drug is working.  What do you think? 

NanoSecond's picture
NanoSecond
Posts: 515
Joined: Oct 2012

I think the consensus is that experiencing side effects cannot predict the efficacy (or not) of any given drug.

And since is it bound to be asked - here is one piece of anecdotal proof (myself).  While on Inlyta at 7mg x2 I suffered from a very hoarse (almost became inaudible) voice.

Last Monday I underwent my latest full-body nuclear bone scan followed by a CT-scan of the Abdomen/Chest/Pelvis with contrast.  This was the first set of scans since I started on Inlyta back in early January.

The scans clearly showed that Inlyta has done nothing for me.  As I mentioned earlier (while trying not to be a pessimistic here - apologies to Fox) I was not too surprised for two reasons.  One, I already knew that Inlyta was totally ineffective against my bone mets.  Even though Sutent was completely effective and was still working before I switched to Inlyta.  Two, my C-Reactive Protein was still way off the charts during the past few months.

At this point I now have several new liver lesions and 2 or 3 of the those that first appeared in early December (which is why I had to stop Sutent) have significantly increased in size.  I also have a new (very small) bone met at my right hip.

Since getting this news I have looked once again for any anti-PD1 or anti-PDL1 clinical trial that might be available.  However, something interesting (to me) has given me pause about this strategy.  For those who have been through the drill, BMS (maker of Nivolumab) has restricted each and every RCC trial to only Clear Cell histologies.  I am now wondering if perhaps they may know something. Maybe that something is that these immune drugs are not effective on chromophobe (and other non clear cell) histologies.

Sorry to be the bearer of bad news (for me at least).  But it is what it is.  Inlyta was a bust for me.

DMike's picture
DMike
Posts: 237
Joined: Nov 2011

Hi Neil,

I've been waiting to hear how your scans went. I knew you were supposed to get the results on Thursday and when I didn't hear anything, I feared it might have been bad news, but I was hoping for good news. 

I'm sorry Inlyta doesn't appear to be working for you. I wish you strength and peace in making the next decision.

David

NanoSecond's picture
NanoSecond
Posts: 515
Joined: Oct 2012

Many thanks David.  Your kind thoughts are greatly appreciated.

DMike's picture
DMike
Posts: 237
Joined: Nov 2011

Neil,

Merck's anti-PD-L-1 drug is MSB0010718C. There are solid tumor trials out there. One is supposed to be administered by my oncologist at the University of Alabama at Birmingham. He gave me the drug name when they were planning the trial. The sponsor is EMD Serono.  I hope this helps in some small way.

David

GSRon's picture
GSRon
Posts: 1175
Joined: Jan 2013

Dang... I am sitting here with my finger up my you know what..  Neil so sory that Inlyta failed you.   Here I was so sure Inlyta would work for you... SH**..  OK, so, time to see what may work for you..  I looked at a bunch of Active / Recruiting Clinical Trails.  Not sure what may interest you, but I bet you have been doing that yourself.  I will absolutely keep my eyes and ears open on my end... you KNOW that.  Plus in San Diego we may hear of something new out there in research land..  Sure hope so..!!

Now I get it why you replied to my CD47 comments... and yes I always ask about it when I get to Stanford, and I will ask again...  you KNOW if it comes down to it, you can stay here with me... if you can stand all the motorcycle parts in the house...  Mybe more wishful thinking.. but..  Holler at any time.. and we will talk more in S.D.

Hang in there pal..!

Ron

NanoSecond's picture
NanoSecond
Posts: 515
Joined: Oct 2012

David - yes I am familiar that both Merck and MedImmune (BMS competitors) have their own new clinical trials.  However, you may not have followed the crux of my issue.  I am now worried that I may be focused too much on looking for immune based therapies that may not work for a Chrommie.

I am a bit spooked because I just wasted 3 months and in that time frame a few liver mets have tripled in size.  This is not good and they now have to be dealt with ASAP.

Ron - of course I greatly appreciate your kind offer.  However, I don't think it will come to that.  What is of immediate concern is that I will be undergoing a rather complex interventional radiology procedure just before the AACR Convention.  The problem is that I have been given the heads up that I will likely be very fatigued for at least several weeks after I undergo it.  This is what p--ses me off most of all.

I now have a team at the NCI (National Cancer Institute), which is located only a few miles from my home, studying my case in order to make their own recommendations as to which therapy might be best for me next.

Many thanks for all your kind thoughts and offers,

 

-Neil

foxhd's picture
foxhd
Posts: 1872
Joined: Oct 2011

Just plain sucks. I think the nivolumab trials were for clear cell only because of a much higher anticipated effectiveness for it. Successful studies facilitate approval quicker. That does not mean that it wouldn't be effective for someone like you. It is playing the FDA game. You'll find something that will work until the next big thing.

NanoSecond's picture
NanoSecond
Posts: 515
Joined: Oct 2012

Thanks Fox.  Yes, I assumed that was the case too - and it very well may be.  But it sure would be nice to find at least someone with chromophobe who has done well on an anti-PD1.

 

angec's picture
angec
Posts: 621
Joined: Mar 2012

Sorry to hear about the new findings, Neil.  I was just thinking about Votrient. TW had CHromophobe and Votrient worked well for him. The issue was the liver enzymes went high and he had to come off. I know Sutent is very similar but I sure as heck would give Votrient a shot!  Hoping you can find an answer soon and start treatment.  Is it wise to even take Sutent while you wait for an answer or is that a no go? Praying for a good response on the next drug.  I also hope you do well with the procedure. I am guessing you are working on the liver mets.  All the best to you!  XX

garym's picture
garym
Posts: 1651
Joined: Nov 2009

Hi Neil,

You are the most focused, well informed and therefore best equipped person I can think of for dealing with this, I know all possibilities will be considered. Sutent was effective for you for a much longer time than most in no small part because of your own attitude and drive coupled with your desire and research to make it so. No doubt that will carry into the next phase of defense as you continue to wage the war. Down but not out, you have weapons available and more are coming, hang in there.

Thoughts and prayers,

Gary

Darron's picture
Darron
Posts: 218
Joined: Jun 2013

I hate to hear the news. I hadn't opened the string if responses and the noticed you and Ron going back and forth. Your insight and knowledge is always appreciated. keep looking Neil, you will find and answer.

NanoSecond's picture
NanoSecond
Posts: 515
Joined: Oct 2012

Ange, Gary, and Darron.

Many thanks for those kind words of encouragement.

Yes Ange, the very first order of business to get a handle on 3 large liver mets (approx. 3cm each).  Unless I find a clinical trial that totally precludes the procedure I will be undergoing radioembolism in the next weeks.  This is a two-step procedure.  First they will "map" all the blood vessels feeding my liver.  Based on this they will then determine the next steps.  They will need to make sure the procedure will be successful and they are concerned that only two of the mets are being fed by the same primary blood vessel but the third one may or may not be.  Regardless, assuming this step goes well they will then calculate the proper dosage of "targeted" radiation delivered via tiny glass pellets directly into the mets to liver.  These custom made pellets will take one to two weeks to be prepared.

The other order of business is to decide on the next systemic therapy.  Again, if I cannot find a suitable clinical trial (which right now does not look likely) I will move on to another drug, most likely Afinitor.  It is time for me to try interferring with some different signaling pathways than the TKI's (i.e. try mTOR inhibition) otherwise perhaps Votrient might make some sense.  Actually if Afinitor does not work for me the next drug I am interested in is Cabozantinib which is a TKI that also blocks c-MET.

I did have a good run on Sutent and so it may be one I will try rechallenging at a latter date as well.

What is of some concern is the speed of growth of those liver mets.  My bone mets (and my primary tumor) were rather indolent.  But this does not appear to be the case for these liver mets.

a_oaklee
Posts: 152
Joined: Nov 2013

Neil,  I'm really disappointed to hear the news that Inlyta is not working for you.  I know you weren't completely surprised by that news.  I was.   Garym nailed it on the head when he spoke about your intelligence and your efforts.  If anyone can handle the research and quest for the next best drug it is you!  I began researching chromophobe type of RCC because I wanted to be of help to you.  This is my first time looking at clinical trial information.  Neil, I have an immense amount of faith in you that you will find the next best treatment.  It sounds like you have aligned yourself with other great minds in the healthcare industry.   You are in my thoughts and in my prayers.  I truly mean that. 

Annie

NanoSecond's picture
NanoSecond
Posts: 515
Joined: Oct 2012

You are so very kind.

I actually now have a lead on two possible immune-based clinical trials (alas they are not anti-PD1 or anti-PDL1) that I may qualify for.  Much yet to be evaluated but I will keep everyone posted - probably by starting a new separate thread.

one putt
Posts: 72
Joined: Sep 2012

Neil, sorry to hear your bad news. I trust with your knowledge of this disease  you will  make an informed decision and choose the best option. You have contributed  greatly to this forum now its our turn to offer our support in anyway we can. Sending my best wishes for good results in the future.IF ONLY the drug companies would open  the anti-PD1 and PDL-1 trials to those diagnosed with chromophobe. I understand why they don't,  but I wish they would.

angec's picture
angec
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Joined: Mar 2012

Neil, one other question.  Were you able to find out if you can do the IL-2 or did you try that already?  Is there any chance of trying the Cabo before the afinitor?  I guess they won't treat you with any drug, until the radiation and surgery is done?  I hope it takes place sooner than later.  Have you changed anything in your diet perhaps?  Praying for you to make the best decision. I wish there was a trial you could get in.  Anything i can do to help?  XX

NanoSecond's picture
NanoSecond
Posts: 515
Joined: Oct 2012

John (One Putt).  Many thanks.  One of the things I have been trying to do is get a second opinion from Dr. Hammers.  But he is so popular and busy that the earliest I can get in to see him is March 27th.

Angec.  Many thanks for your offer.  I did not consider HD IL-2 because it seemed to have such a low response rate for non-clear cell patients.  I was actually hoping to avoid what has just happened to me (wasting my time with a futile therapy). Yes, Cabo is a distinct possibility but so far I have only failed one TKI and I suspect that I will first need to fail an mTOR as well before my insurance company will be persuaded to cover it off label.

As to my diet I have not changed it but I have eliminated a few anti-oxidant supplements (no more Resveratrol, Vitamin C or Milk Thistle).  I am still completely convinced that controlling my blood glucose is extremely important.  Please keep in mind that I am now taking Metformin as well.  It may be complete fantasy but I actually think that now that I have stopped Inlyta I may be psosibly slowing down the progression of those liver mets.  I only say this because the brand new bone lesion on my right hip is not progressing rapidly whereas under Inlyta I definitely had rapid progression of my left femur lesion (I can feel these guys).

Right now I am holding out for a suitable anti-PD1 or anti-PDL1 trial.  But I will have to make a decision by the end of the week.

Many thanks again for all your kind thoughts and prayers.

 

angec's picture
angec
Posts: 621
Joined: Mar 2012

Neil, how long have you been taking the metforim?  I know you think this is crazy, but it is a hormone yes? Do you need it or are you taking it just for the cancer?  I was told by a doctor that any hormone would increase cancer burdens, especially if not necessary.  I am not meaning to scare you. Why did you stop taking resveratrol and the others? You were doing just fine with those. Maybe you need to look at the calendar with your notes.

 

1. When did metform start / when did Sutent fail.  Was the dosage correction at fault at all? 

2. When did you stop taking the vitamins?

Just a thought.  You failed two drugs at the moment, Sutent and Inlyta, wouldn't that qualify you for cabo? Do all doctors really pay attention to the type of inhibitor? Most of them just got by name, half of them don't know what they do, tki, mtor etc.  Just saying, that maybe you should ask and try for what your gut tells you. Maybe you can get it.  I also would try for the il-2. You have nothing to lose. 

Just trying to brainstorm, but I am sure you are on top of it.  Always here if you need anything! ;)  Please don't mind the suggestions. You know what is right for you!  Praying for good decisions.  XX

NanoSecond's picture
NanoSecond
Posts: 515
Joined: Oct 2012

Hi Ange,

Thanks for your concerns.  First, Metformin is not a hormone.  It's also know as Glucophage and it is derived from a certain fungus.  If you are interested I can send and point you to numerous studies that show that those patients taking Metformin (Type II Diabetic patients) seem to do much, much better cancer-wise than those who don't.  That is why it is currently the center of at least 60 different medical research programs right now.

I started taking Metformin only after Sutent had failed me.  I started on it in early January.

Yes, it is possible that my lowering my Sutent dosage to 37.5mg (continuously, with no breaks) might have contributed to allowing mets to take hold in my liver.  There is really no way to know for sure.  All I do know is that Sutent had not failed to control my bone mets even at that lower dosage.

Finally I have never been a big fan of vitamins taken as a supplement.  I prefer to get them in my diet.  The only vitamins I take at this point are Vitamin D3 and K2.

I cut out Vitamin C because it is primarily an anti-oxidant and there have been recent studies that hint at the possiblity that too many anti-oxidants - when only taken as a supplement (but not from foods) - may actually promote the growth of certain cancers.  In particular the studies have centered on Vitamin E; Beta-Carotene; and (this one being new) N-Acetyl Cysteine (NAC).  I failed to list NAC as one other supplement that I have also stopped taking.

Since I have only failed TKI's (Sutent and Inlyta) it could be argued that I have not explored all of the standard therapy options.  That is why my insurance company could say they will not cover Cabo until I try an mTOR.

To be honest (and I know this will get me in trouble in many quarters) I am not anxious to subject myself to HD IL2.  Maybe in the future but right now I still prefer the more subtle approaches to stimulating my immune system.

I do appreciate your brain-storming these various ideas.  I have spent a lot of time researching this disease and what might be the optimum approach to handle it.  But that does not mean I am right.  I am always questioning every decision I make.  In the end I may be wrong to try to strictly follow only the latest science but hopefully whatever I pursue will be useful for someone else if even to illuminate what not to do.

angec's picture
angec
Posts: 621
Joined: Mar 2012

Hi Neil.. thanks for the explanation.  I think you are right on all points.

 

This is the info i remember reading about Metforim for those not diabetic.  I am sure you have seen it all!

http://www.lef.org/magazine/mag2012/nov2012_metformin-makes-headline-news_01.htm

 

GSRon's picture
GSRon
Posts: 1175
Joined: Jan 2013

HI All..!!  Well, it is my turn to study for the next tests...  My Onc wants to try and use Contrast this time.. the first in almost two years..!  Wow, yes it is now 12 years since my surgery..!  I will up my water intake until I feel like a fish.. except I won't be ahem getting my excretions in it..  Surprised   I am pretty sure I know why.. and I agree.  "IF" the Inlyta has continued to shrink the Mets and "IF" some of the Mets are super tiny.. then my Onc wants to be able to properly see for sure.  My take is this will help decide on my doseage as well.  As long as there is some shrinkage or at least stability, then life is very good indeed..!!  I will take stability, and hope for shrinkage..  I have about a month before the testing..

Be Well All..!!!

Ron - Fired my racer up yesterday... terrorized the neighborhood... great fun..! Smile

garym's picture
garym
Posts: 1651
Joined: Nov 2009

what's so terrifying about a sight challenged cancer patient buzzing around on a racing bike, SHEEEEEES, must be a bunch of couch spuds living by youWink Good luck on the scans, plenty of water before and after, you know the drill.

GSRon's picture
GSRon
Posts: 1175
Joined: Jan 2013

Gary, thanks for the laugh..!  Yes there are a bunch of olde farts in my neighborhood... but then I did chose a time when many were at church.. Only a few close by here know of my Cancer.

I got Kudos last summer that I was not "hollering" Cancer all over the race paddock area.  They all know I got it.. and many ask how I am doing.. but it was mentioned that they liked the fact that I was not on a Crusade of sorts.  

On the race bike. well.. it is LOUD.. very loud.. and last time I did this little ride, there was an authoritative type person looking for me..... I spotted his official vehicle parked on the next road where he could see in to my garage..  Fun stuff..!!

So, yes just finished two glasses of water.. more to follow...

Take Care..!

Ron

GSRon's picture
GSRon
Posts: 1175
Joined: Jan 2013

OK, mid April is scan time here... I do expect good results..!  Most likely I am going to get contrast this time.. and just for good measure a Phlebotomy as well...  Time to get my review from the "Warden"..  Hoping for another 90 day pass...!!

Be Well All..!!

Ron

angec's picture
angec
Posts: 621
Joined: Mar 2012

Ron, i got good vibes... only great results for you!  <3

GSRon's picture
GSRon
Posts: 1175
Joined: Jan 2013

OK, for the "mature" folks around here... remember Kenny Rogers and the First Edition..??   Well, I never did drugs in college.. but many of us are making up for it now...  Here is an oldie song for sure...

http://www.youtube.com/watch?v=Gfa6umSlR8A

Ron

GSRon's picture
GSRon
Posts: 1175
Joined: Jan 2013

Just a quick update... Friday evening I notice I had a sore spot in my mouth.. by Sunday, I had a few sore spots.. and very painful to the touch... Yes, mouth sores..  So, I e-mailed my Doctor, then later decided to make that phone call.  I got an "On Call" doctor and he quickly did the questioning... and sent off the perscription for the "Magic Mouthwash."  And of course instant relief..!    In hindsight I should not of waited so long... even 2 days makes a difference some times....  I am surprized that it took 2 months on Inlyta for this to show up... guess I am very lucky..!!

Hope you all are doing well...

Ron Smile

DMike's picture
DMike
Posts: 237
Joined: Nov 2011

Hi Ron,

Just checking in to see what condition your condition was in. Sorry to hear about the mouth sores. Sounds like "Magic Mouthwash" did its job. But I believe you've been on Inlyta longer than 2 months. You started before me and I've been on Inlyta for 3 months.

I go for labs and a clinic visit on Thursday. This will be the first bloodwork for me since moving up to 10 mg 2X day. I hope my bilirubin will be okay. I'm doing okay at that dose, no bad side effects yet, except fatigue, knock on wood!

David

GSRon's picture
GSRon
Posts: 1175
Joined: Jan 2013

Hi David... nice catch... try 6 months... sorry about that...  it is time for my 2nd scans...   So far the mouthwash helps... time for another rinse..  the stuff tastes just fine...!

Ron

GSRon's picture
GSRon
Posts: 1175
Joined: Jan 2013

Saturday... even with a couple of mouth sores, Saturday was a blast.. check these pictures out...  http://photos.mercurynews.com/2014/03/29/photos-2104-clubmans-all-british-weekend-motorcycle-show-in-san-jose/#6

 

Yes, the #6 picture is my bike...  Cool

 

Ron

danbren2's picture
danbren2
Posts: 171
Joined: May 2013

GSRon,

     Here's hoping and praying that your scans are great this month!

                                                                   Prayers for good health!

                                                                    Brenda

DMike's picture
DMike
Posts: 237
Joined: Nov 2011

Ron,

Good luck on your scans.

I'm a big motorsports fan, so I loved the moto photos! Your bike is badass and a great photo from the IOM.

Keep fighting, David

a_oaklee
Posts: 152
Joined: Nov 2013

My husbands scans are due in a couple weeks.  He has been taking Inlyta for 1 year!  Big time fatigue.  Decreased appetite and nausea successfully treated with meds.  Good luck to all of you on your followup appointments.

 

GSRon's picture
GSRon
Posts: 1175
Joined: Jan 2013

The best thing we can all do is keep on living..!  Thanks all for the kind words.. the Magic Mouthwash is working...  San Diego next week, scans the week after...

Every day is a cause to celebrate... we wake up and see the sun... time to hoot and holler..!!

Be Well All..!!

Ron

Eskimo lily's picture
Eskimo lily
Posts: 43
Joined: Aug 2013

Ron, that bike looks pretty cool! Thanks for sharing :)

my mom had pretty nasty mouth sores when she was on afinitor and they prescribed an oral steroid rinse that really helped get rid of them quickly! It was a dexamethasone mouth rinse...I forget the dosages but I'm sure your onc will know about it! Magic mouth wash helped with the pain but he dexamethasone helped get rid of them. Hope this helps!

mom just started on inlyta 3mgx2 2 weeks ago and so far (knock on wood) no side effects yet except for a little rise in blood pressure (140/80). 

David, how did the blood work go on Thursday? Any improvement in your bilirubin??

NanoSecond's picture
NanoSecond
Posts: 515
Joined: Oct 2012

Always keep in mind that steroids will weaken the immune system.

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