Mar 08, 2013 - 1:44 pm
Have anyone tried/heard of inhaled IL-2? It is much better tolerated and I read two articals as below. Has anyone's oncologist recommended this treatment? I think it seems better for elder people who cannot tolerate systemic IL-2..
"Dr. Heinzer and colleagues, retrospectively, reviewed overall survival in 97 patients with high-risk renal cell carcinoma that had metastasized to the lungs who were treated with inhaled IL-2 in nine German centers and compared the results with those of 103 similar patients who had received systemic IL-2 for approval studies.
They defined high-risk patients as those with Eastern Cooperative Oncology Group (ECOG) 2 or greater performance status scores, or ECOG 1 plus two metastatic sites and a diagnosis-to-treatment time of 24 months or less.
In all, 28% of the patients had ECOG 2, 87% had diagnostic treatment interval of 24 months or less, and 97% had metastases to the lung and other sites. In addition, 31% previously had not undergone nephrectomy, but 11% previously had received chemotherapy, and 17% had prior immunotherapy.
Patients were treated with 6.5 million units (MIU) of inhaled recombinant IL-2 six days a week for a median of 10 months. The patients also received 3.3 MIU of systemic IL-2 on the first day of each six-day cycle.
The treatment was well-tolerated, with coughing being the primary adverse event. There were no reported systemic toxicities with the therapy, Dr. Heinzer said.
The five-year survival rates were 21% for patients treated with the inhaled formulation compared with 0% for controls. Of the 45% of patients taking inhaled IL-2 who achieved a complete or partial response or stable disease, 35% survived up to five years. In contrast, 33% of patients receiving systemic IL-2 had a complete response, partial response, or stable disease, but none of these patients lived for five years."