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LAckerm1's picture
Posts: 15
Joined: Mar 2011

My husband has been battling colon cancer since Jan 2004. Had surgery and 6 months of chemo. All was well until Jan 2011 when spots in pleural lining showed up plus mediastinal lymph node involvement. Biopsy confirmed metastatic adenocarcinoma. Has been on weekly treatments since Jan 2011 advancing from one to the next as they stopped working ( 5FU, OXILAPLATIN,IRINOTECAN, avastin, ERUBITUX) and now Stivarga. Also did a phase one clinical trial, had cyber knife on a rib that was impacted by tumor and recently had a drain put in pleural cavity for drainage. We are fortunate to live in Cleveland and have had wonderful medical care at Seidmen Cancer Center.  I also feel lucky to work for the same hospital system where he has been getting his treatment.  At any rate he is in his 2nd round of Stivara (4 pills daily for 3 weeks and one week off). I have tried too find info from others on this new treatment without success, so, I am reaching out via this site to anyone who has any experience with it. At this point I feel that he is getting weaker and drifting further away from me daily.  

Lovekitties's picture
Posts: 3132
Joined: Jan 2010

I have no personal knowledge of this drug.  In fact I had a hard time finding it on the net.

I finally went to the FDA web site.  The following is the link for the label info and also includes more detailed info about studies done, etc.



I hope this may help you.

Marie who loves kitties

renw's picture
Posts: 282
Joined: Jan 2013

Stivarga is the brand name for Regorafenib. It is a promising new treatment thats adds another option after Folfox and Folfiri. I have been told to look into this by a researcher I spoke to, however it is currently not approved in Australia where I am from.

There is debate going atm whether giving folfox and waiting till it fails is better than rotating different chemo agents every few months so that the cancer does not build up immunity. A trial is needed to answer this question. Personally, Rotating chemo protocols makes more sense to me.

steveandnat's picture
Posts: 887
Joined: Sep 2011

I'm staring my second round of Stivarga. The first three weeks weren't too bad but this week has been a little rough. I needed a blood transfusion and have had bouts with vomiting and diarea.  The one week break didn't seem like enough time.  The real side effect seems to be tiredness.  That could be from doing chemo for so long.  I don't know too many other trying Stivargo but imagine there will be more over time. I was dx June 2009 stage 4 and been through all the regular chemos. Did you have Zaltrap chemo yet ? It is new but my last scan showed it was keeping rectal, liver intack but not controlling the timers in my lungs. This cancer is such a crazy ride. It's nice to meet someone who is also taking Stivarga...we will have to stay in touch. Jeff

dianelynn41's picture
Posts: 71
Joined: Jan 2011

My husband took 3 rounds of Stivarga.  The first worked like a miracle, he had a recurrent tumor that was protruding out where his rectum use to be and in a week it shrank back.  Dr called it a miracle.  We had big hopes, but then it seemed to just stop working.  His cea drop some but no big shrinkage again.  He was so tired and had to have a tranfusion and fought dehydration and his appetite decreased.  Never had diarrea or vomiting though.

He ate most of his meals early in the day, by evening he didn't want to eat anything.  Just had to push lots of fluids, he also did alot of supplements and juicing.

pbec's picture
Posts: 5
Joined: Feb 2013

My oncologist advised that stivarga was just approved for colon cancer late last year. I'd like to hear more from those who are taking it now as this appears to be an option for me. A person who was part of the Stivarga study before its approval for colon cancer has now survived for six years past their estimated length of survival. I hope the very best for you all.  I've been through surgery, six months of chemo and now starting chemo again after mets to mediastinum, neck and abdomen were found post chemo. I was pretty stunned to hear that after all this it is incureable. I'll be 49 next month and I'm already planning to have a BIG 50th. 

renw's picture
Posts: 282
Joined: Jan 2013

Another potential drug in the pipe line is TAS102.

Posts: 1
Joined: Feb 2015

I just started my second round of this drug, 4 th week treatment, and Oncologist reduced the dose to 3 tablets after being on 4, to reduce side effects.

The first three weeks i became much weaker, lighter appetite, and a little more pain, also some weight loss, started 3 pills today but my catscan after 3 treatments showed the tumors were dying in the liver and none had grown larger

You can also reduce this med to two  pills, but i wanted to try another month on the 3 pill option.


I am also stage 4, in Colon,Lungs and Liver


EMAIL MAIL ME ANY TIME AT if we can exchange info Thanks





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