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5fu iv versus 5fu orally. Any advice???

bailee2012
Posts: 60
Joined: Jul 2012

Dr is considering halting oxi temporarily and continuing 5fu and is offering to continue the iv every two weeks with pump for 2days like we have been doing or switching to oral 5fu which I believe is daily.  wondering about any of your experiences with this.  thanks

barbebarb's picture
barbebarb
Posts: 464
Joined: Oct 2011

Any tips will be helpful for me, too. My team is focusing on a lung nodule then liver. I am the rare rectal cancer w/recent brain met. I feel fortunate to have no paralysis etc, and be able to move forward? I dread chemo.... Barb

steved
Posts: 836
Joined: Apr 2004

The drug is the same and there is no evidence that really says either is better at killing cancercells so the main differential is convenience and side effects. I  have done both and found little differeNce in side effects which I think is common and found ingeneral it was very tolerable- worked full time through long courses of oral xeloda (5fu). The convenience aspect is important if it can untie you from regular long trips to hospitals so really in my thinking that is the main difference. It is certainly no less effective than the IV. 

 

Steve

herdizziness's picture
herdizziness
Posts: 3390
Joined: Apr 2010

I had the oral  5fu, Xeloda, I asked my on what the difference was, he said convenience.  I did not Suffer any side affects from the Xeloda. Xeloda for me was 3 pills taken in the morning, 3 pills at night for two weeks with one week off.  It worked very well for me. And two weeks of pills and one week off is standard.

Winter Marie

Jaylo969
Posts: 826
Joined: Jan 2010

I have had both. I had hand & foot problems with both. Orally was much more convenient. The one problem to consider for me was that with my BC/BS plan IV 5 FU was covered 100% whereas the pills go on the prescription plan and I had a co-pay of $60.00. As I was on 2 different strengths my co-pay was $120.00 every 3 weeks.

 

Best wishes!

-Pat

Coppercent
Posts: 142
Joined: Jan 2012

I have been on both and did not have side effects with either.  I did Xeloda with my radiation and liked the convenience.  I worked throughout my treatments and found the Xeloda to be much more convenient.  No trips to the infusion center was convenient.  However, I was told that Xeloda had to be taken exactly 12 hours apart so I set my phone alarm to remind me to eat so that 30 minutes later I could take my Xeloda.  I had Folfox with 5FU and switched to Xelox with Xeloda.  My understanding is that the results were pretty much the same.  But I guess the insurance payment would be a factor to consider.  My insurance paid the same for both.

ktlcs's picture
ktlcs
Posts: 360
Joined: Jan 2010

Which I believe is Xeloda.  My husband tolerated the oral teatment much better that infusions.  As a matter of fact he had little to no side effects.  As long as he ate before he took the pills he was fine as far as side effects went

 

Kathy

smokeyjoe
Posts: 1428
Joined: Feb 2011

I tried 3 months of xeloda,  was not effective for me.....so I'm back on folfiri..... my oncolog. said it's not as effective as infusion.    I found it very convenient, no side effects.....I would have preferred to stay on xeloda.    

danker
Posts: 731
Joined: Apr 2012

I had the third option, a Chemo pump delivering 1 1/4 cc an hour. 24/7.  It was easy to function with the pump. I had the bag refilled each week.

During this time I was also getting radiation Monday thru Friday for five weeks. It all worked! i'm now over 3 yrs beyond initial dx, NED living a normal life!! LOL    

Trubrit's picture
Trubrit
Posts: 1343
Joined: Jan 2013

This is the same regime that my Onc has me scheduled for after my 4 1/2 months of FOLFOX. 

I'm glad to hear it worked well for you.

Did they keep you plugged into the port for the whole time you were on the pump?  Was it for the five weeks of raditation? 

danker
Posts: 731
Joined: Apr 2012

The pump was connected to the port.  Each week they would flush the port, and give me a new bag of chemo. After a 6 week rest, I had the resection & ileostomy.  That was reversed, but a fistula occurred which ultimately healed itself from the inside out..  A colonoscopy the following year showed me NED.  As I have been since.  Good luck to you!!! 

bailee2012
Posts: 60
Joined: Jul 2012

I have come to trust you guys and your experiences more than what I read other places.  thank you for taking time to reply.  we will see what husband decides to do as this is ultimately his journey.

smokeyjoe
Posts: 1428
Joined: Feb 2011

Is it possible for him to get xeloda with Avastin??    I think it would be more effective (although possibility of more side effects) ..... 

bailee2012
Posts: 60
Joined: Jul 2012

We tried avastin a couple months ago.  They gave him half a dose for first time to see how he handled it and the side effects started with just that.  High blood pressure, terrible chest pains and bleeding that resulted in a trip to ER and couple days in hosp.  Doc took that med off the table unless we would need to risk the side effects to try to get the cancer to respond.  It is responding well so far I just hate to pull the oxi off the table also even for a short time.  The doc is thinkin that the oxi is causing the side effects similar to portal hypertension.  I am gonna have them do his cea again before making the decision.  Sometimes it's hard to know what to do....

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