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Mdx 1106/ sutent trial 6 week scan results

tacyarts
Posts: 73
Joined: Apr 2012

FINALLY, some positive news!!! My scans were yesterday and my lung mets have decreased in size. I am so excited, it wasn't a remarkable decrease but I will sure tale it. My 1 mass was 4.7 x 3.6 and is now 3.9 x 3.1 and the other major one was 2.1 x 3.6 and now is 2.1 x 3.3 and my leg tumor was unchanged. God has been good to me but not near out of woods yet, so keep up the prayers .

alice124's picture
alice124
Posts: 881
Joined: Mar 2012

Tac,

Was just wondering if you received the trial report yet that actually assigns an overall reduction percentage?

Hope the Sutent/MDX has started kicking in on that leg.

tacyarts
Posts: 73
Joined: Apr 2012

Am I supposed to get something else, they told my the size reduction by cm and I figured the percentage myself and it looked like 20% in the biggest one in my lung, the other biggest one didn't shrink as much/ maybe 12% but they where my calculations. I kinda figured that they would get me the %'s but just to get the numbers was like pullin teeth. Monica and dr hammers were on vacation and it seemed like it was xtra hard to get results.

alice124's picture
alice124
Posts: 881
Joined: Mar 2012

Yes, after the reading of the initial scan on the day or day after you're scanned, it goes back to the radiologists to prepare another report as required for the BMS trial. It will indicate your entire tumor burden percentage and the overall percentage of reduction. It can sometimes take up to two weeks following the scan, but sometimes you get lucky and get it within days. I think Monica told me they are run either every two weeks or ten days and where you are in that cycle determine when you will receive.

Since Monica has been on vacation, I'd give her a call. It doesn't seem much happens in her absence. She's a jewel. Let us know.

tacyarts
Posts: 73
Joined: Apr 2012

I emailed Monica and my dosage is 2mg/ kg of mdx 1106 per dose. The %'s of shrinkages are not finished yet, Monica said that they are taking up to 2 weeks to get it done. She also got me path. Reports, I have sarcomatoid cancer (furhman grade 4) and original tumor was 7.3 cm.

tacyarts
Posts: 73
Joined: Apr 2012

I emailed Monica and my dosage is 2mg/ kg of mdx 1106 per dose. The %'s of shrinkages are not finished yet, Monica said that they are taking up to 2 weeks to get it done. She also got me path. Reports, I have sarcomatoid cancer (furhman grade 4) and original tumor was 7.3 cm.

alice124's picture
alice124
Posts: 881
Joined: Mar 2012

It's easy to make mistakes with all the medical terminology floating around, particularly when you're participating in a trial. Did your path report say sarcomatoid cancer or sarcomatoid features?

For example, John has on his pathological report: Histological type--clear cell (conventional)
renal cell carcinoma. Then under Histologic Grade: Fuhrman Grade 4 with focal sarcomatoid features. His tumor also was 7 cm.

tacyarts
Posts: 73
Joined: Apr 2012

Alice it actually says sarcomatoid renal cell carcinoma with a clear cell component.

alice124's picture
alice124
Posts: 881
Joined: Mar 2012

The aggressive nature of sarcomatoid makes it a word we don't like to hear, but on the positive front, you've had reduction. Though it's hard, don't get discouraged. You've got plenty of company here with Nancy (Nana Lou), Tex, John, and many others with sarcomatoid features.

Under the sarcomatoid thread, Tex has a lot of reference material you may want to read. The company you've been allianced with through this diagnosis represents some of the Board's heaviest hitters so you're in excellent company. And those of us not directly in the fight have your back. Keep fighting; you're not alone. Let us know what those reduction numbers look like when the percentages arrive.

Hang in there TAC!

tacyarts
Posts: 73
Joined: Apr 2012

Monica had told me the wrong dosage on the mdx, she emailed me back and I actually get the 5 mg dose.

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