Sep 24, 2012 - 3:55 am
"The circadian schedule was far less toxic, allowing almost 50% more drug to be safely given with substantially less toxicity than lower doses given by constant-rate infusion.
This regimen was also found to have unexpected activity in renal cell carcinoma, a disease in which no other cytotoxic therapy has proven useful. Recent French multicenter studies doubled the objective response frequency of a combination of 5FU leukovorin and oxaliplatin by optimally timing these agents within the day"
Timing is everything.
And for CRC; http://www.ncbi.nlm.nih.gov/pubmed/20042412