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Posts: 14
Joined: Jan 2012

Ok, new tactic for 2nd recurrence of uterine adenocarcinoma - mets in the lungs - was ordered today. My background: total hysterectomy 2008, stage 1c, completed only 3 of 6 rounds of chemotherapy with carboplatin (allergic to Paclitaxel) + 3 rounds of brachytherapy. Mets to lungs in 2011 - lobectomy and resection of left lung. Recurrent in March 2012 - Pneumonectomy of the rest of the left lung. Now I have a spot in my right lung, (stage 4, grade 1-2) which we will try Megace on. Any suggestions, or drug reactions I should be aware of? Thanks for your help. I'm needing some support today....Wondering about what else I can do ...

Posts: 24
Joined: Jul 2010


I'm so sorry to hear about your new lung spot. I took Megace earlier this year for a few months for a recurrence. It is a hormonal treatment. I didn't have any problem tolerating it. The only side effect I had was some increased hot flashes. My gynecological oncologist explained that some people can achieve and maintain a disease free period with Megace, and it is a much gentler option than some other treatments. It's effectiveness does rely somewhat on whether your cancer cells have certain hormone receptors. I hope that it is effective for you!
In my case I had a slight tumor growth while on it so we had to change plans.


Posts: 14
Joined: Jan 2012

Thank you for your reply. I am 70-90% estrogen sensitive - I really don't know the right terminology - but since I'm grade 1-2, the doctor thinks this will help. After 3 months, we'll see what effect it has had on the tumor - still could do surgery or radiation, but not sure about my quality of life and lung capacity after that with this being my only lung left... The good news is my CA125 is a 5,-- went DOWN from last time, so I believe that indicates it's still just in my lungs and not anywhere else in my body. But, a lung is an important organ to have !

Still working, wishing I wasn't, but it probably helps keep me from worrying too much.
Thanks again

HellieC's picture
Posts: 506
Joined: Nov 2010

Hi Barbara
Sorry you are facing this - it's a real beast, isn't it?
I am fighting my third recurrence (still confined to pelvis, but inoperable due to proximity to pelvic sidewall). I have been prescribed Femara (generic name Letrozole). It is an aromatase inhibitor which is used in post menopausal women to stop the body producing oestrogen from our other cells (even post surgery and post menopause, we produce oestrogen). My tumour has also tested strongly for oestrogen receptors. I asked my onco why she was prescribing Femara rather than Megace, as there aren't many clinical trials out there to support it. Her response was that there is a lot of evidence from other oncos that this works well. I am going to have an MRI scan at the beginning of November to see how it's working, so I'll keep you posted.
Wishing you well

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