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doing something for Avastin breaks?

tanstaafl's picture
tanstaafl
Posts: 969
Joined: Oct 2010

Reposted and extended for discussion. The Avastin molecule attacks VEGF molecules. We attenuate VEGF by other means. So far my wife has not been forced off her immunochemo by her surgery or dental work. If she were to temporarily stop the UFT (oral 5FU derivative), she would still be doing cimetidine (anti-VEGF) and IV vitamin C (histamine neutralization where histamine levels mediate VEGF generation).

Basically as much of the LEF protocols plus IV vitamin C and MK-4 as she can safely get away with (lots, with some supplement suspensions). In fact for her last surgery, her cimetidine intake doubled for the day. Her IV vitamin C may double or triple to fight infections, cancer and rebuild tissue, after surgery or dental work. I partly rate our execution efficiency by how soon after an invasive procedure that she can get the IV vitamin C infusion. Realizing the metastatic biotype odds with CA19-9 serum values over 15-20, not doing cimetidine looks risky to dangerous to me although the CA19-9 cutoff for initial diagnosis of (pancreatic) cancer is typically 34 - 40, depending on lab.

* A number of Japanese researchers consider the CA19-9 and CSLEX1 pair, used in combination, a fully predictive biomarker for metastatic risk and long term cimetidine benefit.

smokeyjoe
Posts: 1428
Joined: Feb 2011

Hey there, just curious, has your wife had any scans recently?? Just wondering if everything is still good :)

tanstaafl's picture
tanstaafl
Posts: 969
Joined: Oct 2010

CT scan is almost 6 months old, doing multiple biomarkers right now with flat (noisey) CA19-9 and declining CEA among a number of markers. Another scan, 1-2 months.

Sundanceh's picture
Sundanceh
Posts: 4298
Joined: Jun 2009

Sits right at 136...which is of course, off the charts...

It went down one point the last 3 months...was as high as 243 in April 2012.

I'm doing okay though, last week's scan was clear...

CA19-9 marker is a tricky one...we originally used the marker for pancreas, but of course, it also doubles as an additional colon marker like CEA.

Your wife's situation is probably different than mine...I'm doing nothing, but don't feel it is a risk. I've just set the longest clear scan mark at 15-months in my entire 8-years of the fight.

smokeyjoe
Posts: 1428
Joined: Feb 2011

I don't think CEA is a good marker for me....my usual sits at .8, when it was WAAAAY up to 3.5 I freaked at my G.P.'s office....he didn't understand it was within normal range....YEAH right not for me!!! And of course there was progression.....I should ask my onc. for CA19-9 marker....I already know what his response is gonna be....."why would you want this"....

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