Apr 30, 2012 - 5:27 am
haven't got a straight answer on this from Onc...
My wife, who is stage IV with significant liver mets, has been on FOLFOX w/avastin since December, having just completed her 10th treatment. two to go, then possible colon surgery.
I noticed her alkaline phosphatase has been steadily trending up for last 2 months. came down initially, falling to below 140, now at 240. from what I gather this is not a good thing at it may indicate disease progression - tumors becoming unresponsive to chemo. prior to this period her CEA bottomed at about 300 but then rose to 500 for last two visits. late March PET/CT did see indications that colon tumor has become more active while liver mets are still responding to chemo....