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ASPIRIN - !,543 B.C. to 21st April 2012 announcement

Texas_wedge's picture
Texas_wedge
Posts: 2807
Joined: Nov 2011

Mechanism of aspirin benefit uncovered
21 Apr 2012

Researchers in Canada, Scotland and Australia have discovered that salicylate, the active ingredient in aspirin, directly increases the activity of the protein AMPK (AMP-activated protein kinase), a key player in regulating cell growth and metabolism.

AMPK which is considered a cellular fuel-gauge is switched on by exercise and the commonly used anti-diabetic medication metformin.
The research from scientists at McMaster University, the University of Dundee and the University of Melbourne will be published in today’s issue of the journal Science.
“We’re finding this old dog of aspirin already knows new tricks,” said Dr. Greg Steinberg, a co-principal investigator of the study. “In the current paper we show that, in contrast to exercise or metformin which increase AMPK activity by altering the cells energy balance, the effects of salicylate is totally reliant on a single Ser108 amino acid of the beta 1 subunit.

“We show that salicylate increases fat burning and reduces liver fat in obese mice and that this does not occur in genetically modified mice lacking the beta1 subunit of AMPK,” he said. Steinberg is an associate professor of medicine in the Michael G. DeGroote School of Medicine at McMaster University and the Canada Research Chair in Metabolism and Obesity.

These findings are important as a large clinical trial is currently underway testing whether salsalate (a well-tolerated aspirin derivative), can prevent Type 2 diabetes.

Salicylate, which is derived from willow bark, and is the active ingredient in aspirin, is believed to be one of the oldest drugs in the world with first reports of its use dating back to an Egyptian papyrus in 1543 BC.

An anti-inflammatory drug first used as a painkiller more than a century ago, aspirin is now given to people at risk of heart attacks and strokes as well as patients with vascular disease. McMaster scientists played a key role in that previous research.

Three studies published last month in the medical journal The Lancet reported that taking an aspirin every day may significantly reduce the risk of many cancers and prevent tumors from spreading. The unanswered question was how this anti-cancer benefit occurs.

With many recent studies showing that metformin may be important for cancer prevention the authors’ study raise the interesting possibility that aspirin may also be working in a similar manner; however, further studies are needed as the concentrations of salicylate used in the current study were higher than the cancer trials. Nonetheless, the researchers’ results show the one thing that salicylates and metformin hold in common is their ability to activate AMPK.

Source: McMaster University

foxhd's picture
foxhd
Posts: 2066
Joined: Oct 2011

I had mentioned in an earlier thread that if aspirin was invented today, it would be too expensive and require a script. No doubt about it.

Texas_wedge's picture
Texas_wedge
Posts: 2807
Joined: Nov 2011

I hope it won't apply to the new hybrid - aspirin + NO + H2S - staggeringly more powerful than straight aspirin and threatening to dispose of the potential problems of using aspirin long-term. It would put a powerful new weapon into our anti-cancer armoury. See

http://ecancer.org/news/2557

"New hybrid aspirin shrinks tumours, curbs cancer cell growth"

braswelm's picture
braswelm
Posts: 41
Joined: Oct 2011

Hey TW,
My doctors have cautioned me not to use aspirin, or any other NSAID, as they are filtered by the remaining kidney. And I have read many articles agreeing with them.
Wonder if this new hybrid aspirin will be any different?
Mike

Texas_wedge's picture
Texas_wedge
Posts: 2807
Joined: Nov 2011

That must be the hope Mike. If the promise is fulfilled it should remove all embargoes on what is an enormously valuable drug.

Of course it all depends on the individual patient's profile.

That's the hope Mike - that if the promise is fulfilled it will remove all embargoes on what is an enormously valuable drug.

Of course, everything depends on the individual patient's profile. There are many treatments that have a downside but the benefits are so important that the contraindications should be ignored (or ways found of combating them). Having only one kidney is no good reason to avoid NSAIDs unless the performance of that kidney is compromised (or, perhaps because it's being overloaded due to other conditions?). If you're recovering from surgery and/or at risk of bleeding, that's another reason to avoid NSAIDs.

Won't it be great if the envisaged hybrid allows everyone to access to, among other things, the benefits aspirin gives re heart health, reducing stroke risk and giving anti-cancer protection?

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