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MDX-1106, part three

foxhd's picture
foxhd
Posts: 1872
Joined: Oct 2011

OK. Here we go. First of all, excuse me as I am getting a bit emotional. I do know that I am going to cry tonite. Second of all, if I begin to slur my words it's because some one told me to have a couple beers to celebrate. So, I took my own advice!

Went for 7th infusion today of 10 mg/per kilogram of body weight of MDX-1106. Or Anti PD1. But first was the Doctor visit.

To rehash for many newer members, I had a left radical nephrectomy for stage 3 cancer in March 2011. Recovered well last summer with negative scans. In October 2011 found out I had numerous tumors in my lungs, liver, and chest lymph nodes. My local oncologist said she could do nothing for me. Maybe I would not make through March 2012. I needed to go to a bigger cancer center. A friend pulled some strings and got me to see a top rated oncologist at a bigger center. Bottom line is he said "Good Luck". He agreed that if I was his own family member then Interleuken 2 was worth the chance. But they didn't do it!

So I got to Yale in a bit of a panic. Yes. They could treat me with the Interleuken but......Maybe, I would like to hear about a trial drug of MDX-1106. This drug blocks the programmed die off of T-cells in our immune system allowing the T-cells to attack cancer cells. Specifically Clear cell renal cancer and melanomas....There were to be a limited number of candidates accepted into this trial. But I had to meet all the criteria. I really liked the idea and went for it.

Many weeks of blood work, genetic testing, ct scans, pet scans, bone scans, brain scans and biopsies took place. Then I recieved the news. My first infusion was to begin in December then every 3 weeks there after. Ct scans every 6 weeks.

By the end of December and in January, the cancer now had spread to my pelvis and spine. Very painful. I was needing percocets to get around the house.

But my pain started going away. I returned to exercise and running. I continued with treatment and my scans began to show healing in my bones. My lung and liver tumors were shrinking. Some are GONE!! I am feeling GREAT!!

So Today I go in for infusion #7. Pre-treatment, I meet with my Doctor to review my latest scans. Was I anxious?..Just lay it on me Doc. She says ,"So how are you?" I told her I'm excellent unless she tells me otherwise. She smiles and says," Some tumors are only half to a third of what they were. Some are gone."I am getting excellent response from the drug. Side effects are minimal. Not even worth mentioning.

I am getting better!!!!!!! How do I express how thankful and fortunate I am?

I want to thank all on this board who share their stories, support and love. We are going to win this challenge!

Now excuse me while I cry a little and finish my beer.

Texas_wedge's picture
Texas_wedge
Posts: 2807
Joined: Nov 2011

Thank goodness, Prognosticator, I wasn't sure, so that's a great relief.

alice124's picture
alice124
Posts: 860
Joined: Mar 2012

Tex,

I'm sorry that family health also is an issue you must deal with. I can tell by your posting that you're a bit down, only to be expected as you've expressed your fondness of your wife's cousin in earlier postings. Wishing you the best in a bad situation.

But PLEASE don't lose your FIGHT gene and that "habitual bullishness" we all love. I'm counting on two for two in good reports (you and Fox)!

Texas_wedge's picture
Texas_wedge
Posts: 2807
Joined: Nov 2011

Alice, both Fox and I were keen to oblige and now, with his results in, it's one down, one to go, where, of course, "down" is up and "one to go" is one to not go :-)

Texas_wedge's picture
Texas_wedge
Posts: 2807
Joined: Nov 2011

Thanks Alice, Colin is clever, kind and very courageous with a family in which he is a larger than life central figure for whom everyone is hoping against hope that he pulls through the dire straits he is now in. I only hope he is still with us by the time My Wife and I get up to London.

Both Fox and I were keen to oblige and now, with his results in, it's one down, one to go, where, of course, "down" is up and "one to go" is one to not go :-)

alice124's picture
alice124
Posts: 860
Joined: Mar 2012

Tex,

I can't seem to find Chris Lawing's posts that you note above. I'm familiar and a big fan of Chris Battle but haven't heard of Chris Lawing before now. Do you have a link or any other info?

Texas_wedge's picture
Texas_wedge
Posts: 2807
Joined: Nov 2011

Alice, try his post there on 1/5/12 for starters. If you don't find it rapidly, let me know and I'll pmail you a url.

foxhd's picture
foxhd
Posts: 1872
Joined: Oct 2011

Will be ending this part soon. Scan this Friday. Results weds. the 30th. Will probably add the recent diagnosis of both basal cell and melanoma cancer to my journey.

matchframe
Posts: 58
Joined: May 2012

I just read through the whole thread and all I can say is Awesome!! Looking forward to hearing your results on the 30th!!

feistyD's picture
feistyD
Posts: 21
Joined: Nov 2011

Hi, I am just starting a clinical trial with MK-3475, which my doctor says is very similar to MDX-1106. I am in Part C of the trial, which is for NSCLC (non-small cell lung cancer). I just wanted to say it is very encouraging to read your story. I haven't found anyone else on my trial yet (it just started) so I am excited to learn about your results, albeit with a different drug and a different cancer. It's the same mode of treatment, however (anti PD-1). I too don't really have any side effects except some slight fatigue. Won't know if it's working for a while, so in the meantime I will just keep active and positive. Continued good luck to you!

foxhd's picture
foxhd
Posts: 1872
Joined: Oct 2011

.Same to you feistyD!.Anti PD-1 may be the ticket. Stay positive. Any negative thoughts are a waste of good energy. Life is for the living.

sunlover_56's picture
sunlover_56
Posts: 110
Joined: Apr 2012

I agree, negativity is a waste of time. Hoping for the best with you and your results on the 30th!!

LynnLuc's picture
LynnLuc
Posts: 24
Joined: Sep 2010

I have stage 4 melanoma and in June 2009 they said I had 6-9 months....I did some radiation,temodar  and eventually had surgery...then began BMS's Anti PD-1 ( MDX 1106) I have been NED ,,,no evidence of disease,,, for 2 years and 9 months so far :o)- Lynn

foxhd's picture
foxhd
Posts: 1872
Joined: Oct 2011

Boy, that is so nice to hear. Lynn, where do you recieve treatment? How many doses have you had and what is your dose?  I have yet to meet anyone else being treated at Yale.

alice124's picture
alice124
Posts: 860
Joined: Mar 2012

Music to our ears Lynn!!!  Congrats!!!!

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