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Iron is not always your friend, and why you should be very careful in regards to cancer growth.

california_artist's picture
california_artist
Posts: 859
Joined: Jan 2009

More info to help you figure things out. You might want to go to the Nutrition Science News site to view this article. This is a url for a slew of articles on cancer and nutrition. http://www.chiro.org/nutrition/Cancer.shtml#Cancer_Prevention_Diet
I haven't read any of them yet.

Best,
Claudia

From The June 2000 Issue of Nutrition Science News
by Bill Sardi
http://www.chiro.org/nutrition/Nutrition_Archives.shtml#Iron_Too_Much_of_a_Good_Thing
Recent studies reveal that blood donors exhibit lower rates of many diseases and experience better than average health. Additionally, the centuries-old practice of bloodletting is being revived as a treatment for disorders such as heart disease, cancer and Alzheimer's. [ 1 ] Why would blood reduction improve health parameters? In part, because blood removal helps to control circulating iron levels.

Iron is an essential component of hemoglobin in red blood cells, is associated with strength, and is required for oxygen transport, DNA synthesis and other processes. But it also has a destructive nature. In its free form, unbound from hemoglobin or other binding proteins, it accelerates oxidation or "rusting" of body tissues. Since iron-induced oxidation worsens the course of virtually every disease, iron control could be a universal approach to disease prevention and therapy. [ 2 ]

Whereas poor iron intake, or impaired absorption, may lead to anemia, too much iron—iron overload—is even more problematic. [ 3 ] After full growth is achieved, at about age 18 or so, excess iron accumulates in the blood of all humans at the rate of 1 mg per day. [ 2 ] About 80 percent of the body's iron stores are in the blood. Women are less at risk for iron buildup than men because of the blood they lose monthly during menstruation. As a result, women have somewhere around half the circulating iron levels as men. Their rates for heart disease, cancer and diabetes are also about half those of males. Because men have no direct outlet for iron, by age 40 their iron levels are similar to those of a postmenopausal 70-year-old woman. This amount of iron can lead to premature aging and diseases such as arthritis, cancer, cataracts, diabetes, osteoporosis, and retinal, liver and brain disorders. [ 4 ] Postmenopausal women, or women who have undergone early hysterectomy in their 20s, 30s and early 40s, may experience similar problems. [ 5 ]

Recognizing The Problem

Iron overload hasn't gone completely unnoticed. There are a number of books on the topic, but most are written for health professionals, leaving the public largely unaware of the problem. Also, some confusion exists regarding the role of iron in health and disease. First, there is a mistaken idea that the majority of the people affected by iron overload diseases have the genetic form, called hemochromatosis, which affects only about 1 million of the estimated 275 million Americans. In fact, the potential threat of iron overload is universal. It comes with advancing age and regardless of genetic factors. Second, the emphasis on preventing anemia in children and menstruating women has detracted attention from progressive iron buildup in adult men and postmenopausal women. [ 6 ]

Upon closer inspection, many health-promoting practices inadvertently control iron. For example, taking an aspirin a day to prevent heart attacks and strokes causes blood loss via the digestive tract on the order of about a tablespoon per day. This results in iron loss. [ 7 ] Raymond Hohl, M.D., an assistant professor of internal medicine and pharmacology at the University of Iowa in Iowa City, says even chronic use of a baby aspirin may help to control iron and in some cases can induce iron-deficiency anemia. [ 8 ] Aspirin also appears to increase the production of ferritin, an iron-binding protein that prevents iron from inducing oxidation. [ 9 ] By exercising, a person loses about 1 mg of iron through sweat. [ 10 ] Fasting and vegetarian diets, both of which promote longevity in animals and humans, limit iron consumption because red meat contains the highly absorbable heme iron. Whether or not related to iron consumption, restricting red meat consumption has been shown in various studies to reduce the risk of colon cancer. [ 11 ]

Normal Iron Regulation

In healthy individuals there is little if any unbound iron circulating in the blood. In all disease states, however, unbound iron (also called free iron) is released at sites of inflammation and can spark uncontrolled oxidation. [ 12 ] Fortunately, there are numerous automatic mechanisms in the body that help to control iron, many by chelation—compounds that bind to a toxic substance (such as iron) and render it nontoxic or nonactive. Albumin, a simple protein found in blood, acts as a chelator by loosely binding to iron. [ 13 ] Ferritin, produced in the liver, is another iron-binding protein. [ 14 ] Transferrin is a protein that chelates iron and totes it back to the liver, where it is metabolized and excreted. [ 15 ] The liver produces lactoferrin, another iron chelator, when challenged by infectious agents. [ 16 ] This is important because pathogenic organisms such as viruses, bacteria and fungi require iron for growth. Furthermore, as iron stores increase, the gastric absorption of iron decreases. So the body employs numerous mechanisms to control iron that are activated when threatened by disease. However, these defensive mechanisms can be overwhelmed.

Blood tests for iron levels (i.e., hemoglobin and ferritin levels are checked for transferrin saturation percentages) are often useful, but the results of these tests are confounded in states of prolonged inflammation or disease. [ 17 ] A skilled hematologist is often the best professional from whom to obtain personal information concerning blood iron levels.

Differentiating between anemia and iron overload can be difficult because both conditions cause fatigue. One study at the Department of Medicine, University of Western Ontario in Canada, found that iron overload can produce a wide range of symptoms, such as joint pain (particularly hip), unexplained gastric pain, frequent infections, skin bronzing, elevated liver enzymes, cessation of menstruation, hair loss and heart flutters (fibrillation). Yet, of 410 iron-overload patients, 27 percent experienced no symptoms whatsoever. [ 18 ] Common symptoms of iron-deficiency anemia are lowered resistance to infections, fainting, breath holding, mental fatigue, sleepiness, cold hands and feet, and cravings for ice, meat or tomatoes, all which are more likely to occur among women. [ 19 ]

Dietary Iron Control

Various dietary practices can help control iron levels. In a relatively short period of time, dietary changes can result in anemia, iron overload or an ideal state of iron control. Anemia can be induced in about 120 days, while symptoms of iron overload can come on in just 60 days.

Humans absorb only a fraction of the iron they consume, but there are many controlling factors. [ 20 ] Iron absorption rates from food vary widely, from less than 1 percent to nearly 100 percent. [ 21 ] Cooks who use iron or stainless steel pots increase the amount of iron they consume. [ 22 ] Generally, iron in plant foods is not as well absorbed as iron from meat: Only 5 percent of iron in plant foods is available, vs. 30 to 50 percent of iron from meat. [ 23 ] Olive oil and spices such as anise, caraway, cumin, licorice and mint promote iron absorption, [ 24 ] while antacids, eggs and soy reduce availability. [ 25 ] Since dairy products contain lactoferrin, milk also inhibits the absorption of iron. [ 26 ] Moderate alcohol consumption is unlikely to pose a problem with iron absorption, but excessive amounts of alcohol is associated with iron overload, particularly in adult males. [ 27 ]

Vitamin C also increases iron absorption. [ 28 ] However, there is no evidence that vitamin C leads to iron overload. Thus vitamin C should not be avoided by meat-eaters for this reason, since studies show high-dose vitamin C supplements are associated with a decreased risk for heart disease, cancer, cataracts and other disorders. [ 29 ] A vegetarian diet does not generally cause iron-deficiency anemia because there is more vitamin C in plant-food diets, which enhances absorption. [ 30 ]

A 1982 human study was conducted to assess the effect of various drinks on iron absorption. A subject ate a standard meal of a hamburger, string beans, mashed potatoes and water. When green tea was drunk instead of water, iron absorption was reduced by 62 percent. Coffee reduced iron absorption by 35 percent, whereas orange juice (as a source of vitamin C) increased absorption by 85 percent. Contrary to other studies, milk and beer had no significant effect. [ 31 ]

Bioflavonoids (found in berries, coffee, green tea, pine bark, quercetin and the rind of citrus fruits, particularly blueberry, cranberry, elderberry and grape seed) and phytic acid (a component of whole grains and seeds such as sesame) bind to iron and other minerals in the gastric tract and help to limit iron availability. If bioflavonoids and phytic acid haven't bound to minerals in the digestive tract they will get into the bloodstream, where they can bind to free iron, acting as blood-cleansing iron chelators. Therefore, maximum iron chelation in the blood circulation is achieved when these iron binders are consumed apart from meals.

Phytic acid—also called inositol hexaphosphate, or IP6—is comprised of six phosphorus molecules and one molecule of inositol. It has been mistakenly described for decades as an "anti-nutrient" because it impairs mineral absorption. However, in the 1980s food biochemist Ernst Graf, Ph.D., began to tout phytic acid for its beneficial antioxidant properties achieved through mineral chelation. [ 32 ]

Phytic acid in foods or bran should be distinguished from supplemental phytic acid, which is derived from rice bran extract. In foods, phytic acid binds to iron and other minerals in the digestive tract and may interfere with mineral absorption. As a purified extract of rice bran, taken between meals so it will not bind to minerals in the digestive tract, phytic acid is readily absorbed into the bloodstream, where it acts as a potent mineral chelator. [ 33 ] Phytic acid binds to any free iron or other minerals (even heavy metals such as mercury, lead and cadmium) in the blood, which are then eliminated through the kidneys. Phytic acid removes only excess or unbound minerals, not mineral ions already attached to proteins.

Phytic acid is such a potent—but safe—iron and mineral chelator that it may someday replace intravenous chelation therapy such as the mineral-chelator EDTA or iron-binding drugs such as desferrioxamine (Desferal). Because of its ability to bind to iron and block iron-driven hydroxyl radical generation (water-based) as well as suppress lipid peroxidation (fat-based), phytic acid has been used successfully as an antioxidant food preservative. [ 34 ]

Phytic acid supplements should not be taken during pregnancy since the developing fetus requires minerals for proper development. Because aspirin causes a small loss of blood and consequently helps to control iron levels, the simultaneous use of phytic acid with a daily aspirin tablet is not advised. A three-month course of phytic acid should achieve adequate iron chelation, and prolonged daily supplementation may lead to iron-deficiency anemia. Anemic individuals who take phytic acid as a food supplement are likely to feel weak shortly after consumption, whereas iron-overloaded individuals are likely to feel increased energy.

For those at risk for iron overload, it may be wise to avoid iron in multivitamins and shun fortified foods that provide more than 25 percent of the recommended daily intake for iron. No doctor should prescribe iron tablets for patients who complain of fatigue without blood tests and a thorough health history. Iron-rich foods such as red meat and molasses may prevent anemia and build strength during the growing years but in adulthood may lead to iron overload among men and postmenopausal women. Those individuals who learn how to achieve iron balance will maintain the most desirable state of health throughout life.

Moi: This is information you should ideally be getting from your doctors, as cancer just loves iron and copper for that matter. It hates potassium.

This is just to give you a feel for things

carolenk's picture
carolenk
Posts: 909
Joined: Feb 2011

Dear Claudia

Thank you for posting info on iron. I already was aware of the link between iron & cancer and your posting educated me further. I would love to have this posting on the ovarian discussion board--but I post from a phone & haven't figured out how to copy & paste easily.

There seems to be a lot of confusion about anemia. Not all anemias are from iron deficiency--apparently there are medical doctors who are still telling cancer survivors to take iron without investigating to determine that there really IS an iron deficiency.

I feel the way that you do: that knowledge is power. We all need to become better informed if we are to survive.

Thanks again.

california_artist's picture
california_artist
Posts: 859
Joined: Jan 2009

Morning, happy to post it over there too. I will mention your request if you don't mind.

Rewriter's picture
Rewriter
Posts: 496
Joined: Dec 2009

This article is so important and gives such easy-to-understand information about how iron is absorbed (or not), the association between iron and disease, and how to increase and decrease iron storage in the body. I will cut and paste this article into my own folder of research papers.

I hope you are having a lovely day,

Jill

carolenk's picture
carolenk
Posts: 909
Joined: Feb 2011

Yes, please mention my name. I've already written one or two posts on the subject of anemia & iron. This is an important subject.

jazzy1's picture
jazzy1
Posts: 1387
Joined: Mar 2010

I as well was educated over past year on iron and cancer. I don't add any new iron per supplements, as get just enough via my diet.

Thanks Claudia~
Jan

RoseyR
Posts: 464
Joined: Feb 2011

Thanks for sending such a great piece of research on iron, Claudia.

While I too suspect that foods are a better source of many nutrients than supplements, I have been prescribed a multivitamin/mineral that has NO iron or copper, both of which are associated with increased cancer growth.

Its name is Nutrient 950 or Formula 950. Believe manufacturer is Pure.

Rosey

carolenk's picture
carolenk
Posts: 909
Joined: Feb 2011

Dear Claudia

I came across this info on Artmesinin and thought this thread might be a good place to post it. Have a lovely Thanksgiving my dear.
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Here is a little biochemistry for you: Iron is required for cell division. What is it cancer cells do more than healthy cells? They divide at a very high rate. So, in order to divide at this high rate, cancer cells have to accumulate high concentrations of iron. In fact, the surface of cancer cells have many more iron attracting receptors than on the surface of a normal, healthy cell. Do you see where this is leading?

The Journal of Life Science (70 (2001): 49-56) reported on a study out of the University of Washington, conducted by Drs Narenda Singh and Henry Lai. So far, this is the most extensive study done in the US on artemisinin.

The study was conducted in a laboratory in tissue samples (in vitro) as opposed to a study on animals or humans (in vivo). Using a radiation resistant variety of breast cancer cells (that also had a high propensity for accumulating iron) artemisinin proved itself to have a 75% cancer kill rate after just 8 hours; and almost a 100% kill rate in just 24 hours.

According to Dr Lam, MD (http://www.drlam.com/A3R_brief_in_doc_format/Artemisinin.cfm):

Artemisinin is effective against a wide variety of cancers as shown in a series of successful experiments. The most effective is leukemia and colon cancer. Intermediate activities were also shown against melanoma, breast, ovarian, prostate, CNS and renal cancer. Although artemisinin is insoluble in water, it is able to cross the blood brain barrier (the water soluble artesunate is the weakness among the derivates) and may be particularly suitable for curing brain tumors, together with Poly-MVA.

According to Dr Rowen, MD in his newsletter Second Opinion, a family of physicians in Vietnam had used artemisinin to treat cancer for years. For over 400 patients treated in the past ten years, using dietary and lifestyle changes and artemisinin, they realized a 50 to 60 percent long-term remission rate. Artemisinin has proven itself to be nontoxic at the required dosage level for long periods of time; and that no significant toxicity in short-term use for malaria at high dose of up to 70 mg/kg per day has been reported either.

Now the weird thing about this herb, the wormwood, is that you can find the plant growing wild, pick it, take it to an herbalist, and it might have no artemisinin in it: not all wormwood plants contain artemisinin. So there’s no use buying the herb bulk.

When the wormwood herb contains artemisinin, it is in one of three forms (some naturopaths use all three, others a combination of two):

A water soluble form called artesunate which is the least toxic and most active, yet has the shortest life in the body (being water soluble it passes through),
Artemether is a lipid (or fat) soluble form with the longest life in the body, but also the most toxic form when used in high doses (which are seldom needed). Artemether can cross the blood brain barrier.
Artemisinin is the active compound of the plant. It too can cross the blood brain barrier and is very safe.
Because of artemisinin’s activity, because it attacks using free radicals to destroy the cell membranes of cells carrying iron, it is not recommended to take antioxidants with artemisinin. However, this doesn’t mean that hydrogen peroxide therapy, ozone therapy, or any of the oxygenation therapies cannot be used with artemisinin to help create an environment in which cancer cells cannot live and begin to self destruct. In fact, many other therapies are suggested when using artemisinin.

Warnings

High doses are neurotoxic (bad for the brain) . People experience trouble walking, problems with nerve and the spinal column and pain response, respiration slows, gets depressed, and cardiac arrest in large animals has been witnessed, but under very high doses.

In humans, so far only one person has had a serious side effect, which was referred to as a "first-degree heart block." It is assumed that doses up to 20,000mg per 70kg male is a safe dosage, although long-term toxicity is not known at this time.

We do know the following:

Do not take artemisinin or any derivates within 20 days of radiation therapy. Radiation spreads iron (leaks) to surrounding tissues.
If iron levels are low, supplementing iron for a few days prior to starting this treatment is recommended.
Laboratory tests should be used to monitor the progress of this therapy: Complete Blood Count, reticulocyte count (will drop initially but comes back after a few weeks), liver function, ferritin levels, Total Iron Binding Capacity, Erythrocyte Sedimentation Rate, C reactive protein, and appropriate tumor markers. Tumor markers might increase during the initial stages of tumor breakdown.
Therapeutic levels (dosages) for those with active cancers can be 1,000 mgs per day, divided into 4 parts), while some physicians recommend 1,600mg per day based upon a 100 pound female. It is a "cooling" herb according to Traditional Chinese Medicine. If you find yourself tingling (too cool) you might want to drop the dosage a bit.

Artemisinin should be taken with fatty foods. Using an essential fatty acid (flax oil, cod liver oil, lecithin, wheat germ oil) will help absorption, as will CLA.

Artemisinin is not considered a "stand-alone" cancer cure, but part of an overall, aggressive, anti-cancer program. High doses of pancreatic enzymes (on an empty stomach), CoQ10 supplementation, detoxication programs and lab work should all be employed when using artemisinin.

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