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Intraperitoneal chemotherapy vs. IV chemotherapy

antcat
Posts: 272
Joined: Jan 2011

Hi everyone, I was just wondering if anyone has gone thru Intraperitoneal chemo and how that worked. I've been on IV chemo for the last 5 years and I don't know, they just can't seem to find the right chemo combination. I understand that IP chemo might work a little better but I also heard that it's a rough treatment.

Just wondering if anyone who had this treatment had positive results.

cfont11
Posts: 115
Joined: Mar 2011

I did not have IP chemo but checked into it before I started treatments. All the doctors I saw said I was not a candidate for it due to my intestines being damaged from the cancer but they all said side effects are worse than for IV chemo. I have a close friend who had it and she was very ill from her treatments. It is hard to say, everyone is different and gets different side effects. Talking to the doctors about the risks and side effects is your best bet.

JoanC's picture
JoanC
Posts: 225
Joined: Jan 2009

Hi,
I had IP and got thru half way before I had to quit due to blood clots in my lungs....but I think it has been good for me. I finished chemo Oct. 2008 and have been NED ever since and my CA125 has stayed at 6....I did not think it was rough but it is different for everyone.
((Hugs)) Joan

Hissy_Fitz's picture
Hissy_Fitz
Posts: 1869
Joined: Sep 2009

I don't know anyone who had IP after first line chemo, but I guess it's possible.

I really wanted to do it but my doctor would not prescribe it, due to my bowel obstruction. He says only 40% of his patients are able to tolerate the full course of treatment, and it uses up precious time to get them back up to snuff so they can go on traditional IV treatments. I still wished I had at least been given the option.

Carlene

lauripiper
Posts: 27
Joined: Jun 2011

I've only heard of it being used a first line treatment but that's not to say it's not possible to do it later. I had IP for 4 of my six treatments and tolerated it well, better actually than the IV treatments. That said I too read all the horror stories of how much harder it is. You just have to do your best to stay ahead of the side effects the same as you would with IV treatments. I also had very long slow infusions with a lot of saline to flush it out, I don't know if that is usual or if that is what helped.

LaundryQueen's picture
LaundryQueen
Posts: 682
Joined: Mar 2011

Laurel: Were you admitted to the hospital for the IP therapy? Are you maintaining some degree of remission at this time?

Thanks for sharing,

LQ

kikz's picture
kikz
Posts: 1284
Joined: Jun 2010

I had the IP put in during my debulking surgery. I didn't have much problem with the port itself except for some minor discomfort when I was laying down. During one infusion I had a lot of pain which they could not figure out. I made it through and they gave me ativan during the next infusion.

I was much sicker with the chemo I received throught the port. I ended up in the hospital twice and chemo was delayed a couple of times. My second time in the hospital prompted my oncologist to end my chemo. I had received all but the last infusion. Now whether all this has to do with the port or the fact that I was getting cisplatin/taxol (pre-surgery chemo was carbo/taxol) I don't know. I do know it was a very rough ride.

Karen

carolenk's picture
carolenk
Posts: 909
Joined: Feb 2011

See if this link works for you--this is a research study comparing IP/IV chemotherapy for women w/ OVCA.

http://www.cancer.gov/clinicaltrials/results/summary/2007/ipchemo-qol0207

Carolen

Tethys41's picture
Tethys41
Posts: 1057
Joined: Sep 2010

Back in 2009, I was told that the results for women who received IP chemotherapy were better than for those who had only IV chemotherapy. Can't tell you the numbers. The study being used for comparison back then even showed that women who did not complete the whole 6 rounds of IP treatment, benefitted from receiving the IP treatments they did recieve. There was no notable difference between the advantage of receiving one or two treatments vs. all six.

lauripiper
Posts: 27
Joined: Jun 2011

I didn't have to stay in the hospital though I could stayed overnight if I wanted. The long infusions usually took around 10 hours. That's because of pre-meds and the usual waiting around that you do. I'm in remission 5 months now, I was stage 3b or c and CA 125 at 13 last time. I insisted on IP because the studies support a better result and NCI recommends it. I did find that many hospitals and dr.'s don't do it because of the perceived difficulty despite the many studies that support it.

paris11
Posts: 132
Joined: Oct 2010

Hi Cat,

I had IP/IV 18 consecutive weeks dense dose tx. I had tx outpatient. I was very apprehensive going into treatment. Hydration is very important. If you are uncomfortable with tx., you can always stop.

I had excellent results.

Best of luck,

Connie

annecris's picture
annecris
Posts: 44
Joined: Jan 2011

I had IP and IV cisplatin and tx from March - July 2009 - 6 treatments (Stage 3C- still NED 2years later!)- had no major problem but also had the very long slow infusions with a lot of saline to flush it out - saline administered the following three days for 4 hrs. each day which I know helped a great deal. The only problem I had was after the 2nd treatment there was some discomfort in my lower abdomen which they said may have been some irritation of the port near the place on my bowel which had been operated on but they slowed the infusions on my next dose and everything was fine after that - I was treated at Sloan Kettering and my dr. told me that other hospitals seemed to have problems with IP - its true though everyone and every case is different - I am so grateful that I was able to tolerate the IP becasue I had read the studies which said the outcomes were better when it was used. Good Luck Hon - You are in my Prayers

Hissy_Fitz's picture
Hissy_Fitz
Posts: 1869
Joined: Sep 2009

Anne....did you do maintenance chemo, as well?

I know you are in the same study that I am doing at MSKCC, and noticed you said you are 2 years NED. I was just wondering how you got them to take you, since their criteria says no more than 3 months may have elapsed since the end of treatment that resulted in remission. In my case, it was the Taxol maintenance that qualified me. I finished first line treatment in March of 2010 and have been off all treatment (except the vaccine) since January, 2011. I don't know whether to say I am 6 months NED or 16 months NED.

Carlene

annecris's picture
annecris
Posts: 44
Joined: Jan 2011

Carlene - I had no maintenance chemo and have been off all treatment since July 2009 - so by the time I began the study in February of 2011 it had been 19 months since any treatment - I did not see the 3 month criteria in the information I was given so I just don't know - sure glad that they took me anyway- have you been feeling OK since the final shot? I have had all the energy back that i had seemed to have lost - I love love love that your CA-125 is such a sweet number - I will have mine done next Wed. when I go for my last monthly check-up - last count was 20 - i am looking for lower but will take the 20 - then its just maintenance every three months for us girlfriend!!!!! Hope we can sync one of those visits in together so i get to hug you in person - Love Ya - Annie

Hissy_Fitz's picture
Hissy_Fitz
Posts: 1869
Joined: Sep 2009

I was told about the 3 month criteria by another patient in the trial, and just assumed she was correct. But I checked just now and did not see it.

I am doing good. Finally going to get my incisional hernia fixed. Dr S said, "You know, you will be out of commission for a month or more." Like that's something new. "And you will have to take medicine for pain." OK....and there is a downside to that? Although he agreed that it's "a very large hernia", he is not all that crazy about me having it done. Not sure why. But I'm tired of not being able to pick anything up, and it's up to the place where my low-rider jeans button across it, so my clothes don't fit right.

I have only been out of treatment since Jan of 2011, so I still worry a lot.

Carlene

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