Positive results reported thus far concerning Aflibercept (VEGF Trap)

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coloCan
coloCan Member Posts: 1,944 Member
edited July 2011 in Colorectal Cancer #1
at:www.ecancermedicalscience.com/news-insider-news.asp?itemId=1859

More will probably be reported on this

and

here's an interesting thought:
"Circadian clock disruption improves the efficacy of chemotherapy through p73-mediated apoptosis"
at:pnas.org/content/108/26/10668

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  • pepebcn
    pepebcn Member Posts: 6,331 Member
    #2
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    Very interesting !
    thank you for sharing it!
  • SisterSledge
    SisterSledge Member Posts: 332 Member
    #3
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    live links
    http://www.ecancermedicalscience.com/news-insider-news.asp?itemId=1859
    Aflibercept significantly improves survival
    http://www.pnas.org/content/108/26/10668
    Circadian clock disruption

    Okay, here's live links but these articles aren't thrilling me with interest...the Aflibercet trial results showed: "The addition of aflibercept to the FOLFIRI regimen significantly improved both overall survival (13.5 months median overall survival vs. 12.06 months in the control arm; HR=0.817; p=0.0032) and progression-free survival (6.9 months median progression-free survival vs. 4.67 months in the control arm" ...one month or so? significant, really?

    The second article's abstract would be hard for some to understand...if I'm getting it right, it relates to tumors that have a mutant gene being affected negatively by circadian disruption.

    Thanks again for the research you share here, though I'm not interested in every piece I can't tell you how much I appreciate every single time you put up some new info!
    Janine
  • PhillieG
    PhillieG Member Posts: 4,866 Member
    #4
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    SisterSledge said:

    live links
    http://www.ecancermedicalscience.com/news-insider-news.asp?itemId=1859
    Aflibercept significantly improves survival
    http://www.pnas.org/content/108/26/10668
    Circadian clock disruption

    Okay, here's live links but these articles aren't thrilling me with interest...the Aflibercet trial results showed: "The addition of aflibercept to the FOLFIRI regimen significantly improved both overall survival (13.5 months median overall survival vs. 12.06 months in the control arm; HR=0.817; p=0.0032) and progression-free survival (6.9 months median progression-free survival vs. 4.67 months in the control arm" ...one month or so? significant, really?

    The second article's abstract would be hard for some to understand...if I'm getting it right, it relates to tumors that have a mutant gene being affected negatively by circadian disruption.

    Thanks again for the research you share here, though I'm not interested in every piece I can't tell you how much I appreciate every single time you put up some new info!
    Janine

    How many months?
    I started Avastin in March of 2004, shortly after my dx and when it first became approved by the FDA. I was part of an AP story on the high cost of drugs and whether they are worth it or not. The claim with Avastin was that is would give the sickest cancer patients about 5 more months to live.
    That was 7 years ago.

    I'm thankful for Avastin and Erbitux, both are part of the new-ish targeted therapies for treating cancer with the hope of doing less collateral damage (ugh! that word...collateral) to healthy cells that traditional chemotherapy but the abstracts that they provide always seem so glum to me. Five months more than those who brush with Crest TM?

    It's good to see that they are trying something but the more I see, the more I see it's mainly medicine that get all funding and then once they approve the medications, many people can't afford it. The Erbitux was $17,000 a month back in 2005. Everything is profit-driven.

    OK, I'm getting side-tracked...too many fireworks!
    I echo Janine, thanks for keeping us informed people Steve
    -p
  • coloCan
    coloCan Member Posts: 1,944 Member
    #5
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    PhillieG said:

    How many months?
    I started Avastin in March of 2004, shortly after my dx and when it first became approved by the FDA. I was part of an AP story on the high cost of drugs and whether they are worth it or not. The claim with Avastin was that is would give the sickest cancer patients about 5 more months to live.
    That was 7 years ago.

    I'm thankful for Avastin and Erbitux, both are part of the new-ish targeted therapies for treating cancer with the hope of doing less collateral damage (ugh! that word...collateral) to healthy cells that traditional chemotherapy but the abstracts that they provide always seem so glum to me. Five months more than those who brush with Crest TM?

    It's good to see that they are trying something but the more I see, the more I see it's mainly medicine that get all funding and then once they approve the medications, many people can't afford it. The Erbitux was $17,000 a month back in 2005. Everything is profit-driven.

    OK, I'm getting side-tracked...too many fireworks!
    I echo Janine, thanks for keeping us informed people Steve
    -p

    Here'a a little article about some of Dr Lenz's research:
    eurekalert.org/pub_releases/2011-07/uosc-url070511.php "USC researchers link genetic marker to rectal cancer treatment."......ieSurgery and Erbitux

    nanowerk.com/newsid=21981.php on nano and cancer
  • PhillieG
    PhillieG Member Posts: 4,866 Member
    #6
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    coloCan said:

    Here'a a little article about some of Dr Lenz's research:
    eurekalert.org/pub_releases/2011-07/uosc-url070511.php "USC researchers link genetic marker to rectal cancer treatment."......ieSurgery and Erbitux

    nanowerk.com/newsid=21981.php on nano and cancer

    Lynx
    or links...
    USC researchers link genetic marker to rectal cancer treatment."
    Second link didn't see to be active Steve.
    -p
  • coloCan
    coloCan Member Posts: 1,944 Member
    #7
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    PhillieG said:

    Lynx
    or links...
    USC researchers link genetic marker to rectal cancer treatment."
    Second link didn't see to be active Steve.
    -p

    Of course it didn't work, i mistyped it........left out part of
    the address....At least one of us can still think strait (direly)......

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