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Bone Mestastsis

Posts: 6
Joined: Nov 2010

Does prostrate cancer that has mestastis to bones go to organs as well?

VascodaGama's picture
Posts: 1818
Joined: Nov 2010

My understanding is that prostate cancer spreads to other organs too but it is common to read that it usually metastasizes to the bone. There are several studies indicating the interactions between prostate cancer cells and bone cells which are thought to initiate the colonization of metastatic cells at that site. As well, cells are known to interact within each other (invasively) in laboratory environment.

Here is the opinion from a friend survivor of Pca, Jim Waldenfels, in another forum. He says;

“….The usual first sites for spread are the lymph nodes and bone, especially bone in the spine and pelvis near the prostate. Dr. Charles "Snufffy" Myers, MD, an expert medical oncologist specializing in prostate cancer, wrote " ... the most common site for bone metastases is in the lumbar and sacral spine. The cancer cells in the blood can also ascend to the right side of the heart, where they are then pumped into the lungs. The cancer cells can lodge in the lung wall, but only rarely grow large enough to detect and even then generally don't impair lung function. The cells that pass through the lungs are then pumped out to the rest of the body by the left side of the heart. While this path can lead the cancer cells anywhere in the body, they can actually only grow in the liver, which is rare, or in the adrenal gland and bone, which are common." This is from his book Beating Prostate Cancer: Hormonal Therapy & Diet….”

Take care.


Posts: 21
Joined: Aug 2009

To reply to your question about PCa spread--my husband was diagnosed 1/2007, had rp 2/07, radiation 4-6/07, and of course ht as well. His Gleason was 9, with perineural invasion. After being taken off ht for about a year, a routine chest x-ray and further tests showed lung nodules. Biopsy showed they were prostate in origin. The 3 nodules are slowly but steadily growing, and last fall a bone scan showed rib mets. Regular CT and bone scan scheduled for this week to determine what's happening now.
Doctors comment that it is unusual to find initial spread to lungs, and there is no unique treatment. Now that it's in the bone, he's on Xgeva.
He's 65, is a workaholic so continues, and is in minimal pain. There definitely are quality of life issues from the cancer and the ht.
Hope this info helps, and my thoughts are with you all.

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