Apr 28, 2011 - 5:03 am
skip reading this post as it discusses liver damage from chemo that may result in death.
sorry about upsetting anyone, have made the title more accurate and put in a warning at the front.
again apologies for anyset caused by the original title not being specific enough.
I still hope we all make it and have a great day, but being informed of the risks and issues of our treatments is why I come here, as well as all the great support.
Now I am finished folfox, I am curious about my long term side effects peripheral neuropathy and impared liver function as my most recent blood test was the worst for liver function. I am also aware that the liver function numbers can indicate mets per surgeon. So I have been reading about liver funtion tests. This study came out of that research.
we all know death can result from chemo complications, the specifics of the nature of liver damage is what I am interested in. I wanted to raise awareness and to share what I have found, its what I have been reading about due to my oiwn impared liver. Now I know I am stage 3 and this study applies to stage 4. I thought the stage4 folks would be interested if they were not aware of the complications that can result from irinotecan.
from the study "Steatohepatitis, especially due to irinotecan, is associated with increased postoperative mortality. Sinusoidal obstruction syndrome, a severe form of vascular hepatic lesion, associated to oxaliplatin, seems to be linked with an increase of postoperative morbidity"
I am interested in trying to help my liver repair itself from oxaliplatin damage. I am aware of our livers amazing rebuilding capacities, and this demonstrates the serious damage chemo must be doing if it cannot recover from it.
I also take heart from my own liver friendly diet during chemo that I did my best to support this critical organ that gets worked very hard during chemo.
Realising the specifics of the possible liver damage that may result from oxilaplatin and or itinotecan may help some others do research into how to support their livers by diet, water or whatever they find. They will certainly be more aware of side effects and monitor and understand liver function tests more closely.
My own personal opinion is that while chemo has benefits its side effects are not explained in as much detail at the start. I would have liked to be clearly advised about liver function issues post oxaliplatin.
The sarcasm "the joy of chemo" is how I feel. We are dammed if we do, we are dammed if we don't. Maybe this is my way of venting some frustration at the realisation of the true nature of the damage oxaliplatin has caused. Now I am through the treatment I have the luxury to deal with side effects. especially now my gut has settled down.
the joy of chemo ????????????????
Bull Cancer. 2010 May;97(5):559-69.
RESULTS: Studies concerning the link between hepatic steatosis and chemotherapy have contradictory results but steatosis is clearly associated to an increase of postoperative morbidity. Steatohepatitis, especially due to irinotecan, is associated with increased postoperative mortality. Sinusoidal obstruction syndrome, a severe form of vascular hepatic lesion, associated to oxaliplatin, seems to be linked with an increase of postoperative morbidity, but not mortality. Bevacizumab would not increase, when used in combination with oxaliplatin, the rate of postoperative complications. Some studies suggest a decrease of vascular hepatic lesions when bevacizumab is administered with chemotherapy. The literature concerning hepatic toxicity of anti-EGF-R antibody is freak.
CONCLUSION: The fact that irinotecan may be linked to an increased risk of hepatic failure and postoperative death, which is not the case of oxaliplatine, must be taken in consideration in the choice of the preoperative chemotherapy before resection of hepatic metastasis of colorectal cancer.
PMID:20167564[PubMed - indexed for MEDLINE] Publication Types, MeSH Terms, SubstancesPublication TypesEnglish AbstractReviewMeSH TermsAntibodies, Monoclonal/administration & dosageAntibodies, Monoclonal/adverse effectsAntineoplastic Combined Chemotherapy Protocols/adverse effects*Camptothecin/administration & dosageCamptothecin/analogs & derivativesColorectal Neoplasms/pathology*Fatty Liver/chemically induced*Fatty Liver/pathologyHepatic Veno-Occlusive Disease/chemically induced*HumansInfusions, Intra-ArterialLiver Neoplasms/blood supplyLiver Neoplasms/drug therapy*Liver Neoplasms/secondaryLiver Neoplasms/surgeryOrganoplatinum Compounds/administration & dosageOrganoplatinum Compounds/adverse effectsSubstancesAntibodies, MonoclonalOrganoplatinum CompoundsbevacizumabcetuximabpanitumumabirinotecanoxaliplatinCamptothecin
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Clear Turn Off Turn On [Hepatotoxicity of metastatic colorectal cancer chemotherapy: systematic review]...