any other colorectal vitamin d3 clinical trials running or planned

Memorial Sloan Kettering Cancer Center
in NYC has been doing research on Vitamin D and stage 4 Colorectal cancer. I tried to get into the study, but couldn't (appendix cancer didn't qualify.) However, one of the investigators, Dr. Kathleen Wesa, has been seeing me as a patient to control my D-levels.

I don’t have cancer, but ……
I started taking vit d3 about six months ago. I had a blood panel done and it showed that my D levels were really low and that I had hypothyroidism. My blood pressure was also high. I did not want to take any prescription drugs,so I did a ton of research and found that low levels of vit D can cause high blood pressure and hypothyroidism.

I started on 10,000 IU a day for three months,and I’m currently taking 5,000 IU a day.

I have had good results so far. I no longer have insurance, so getting a blood panel is out of the question. But, I check my blood pressure often and it has gone down.


Hope the helps.

D

test trials and negative advice
Great info update, Pete.

I am glad there are D3-cancer trials but I have to say, several elements in those trials surprise me. First, a single dose of 100-200,000 iu for up to 21 days presurgery and then what vit D protocol in the following 5 years, for presumably advanced CRC underwhelms me. Post surgery vitamin D3, not specified as far as I know, so 400-600 iu D3 per day post surgery? Or maintain >32 ng/mL?

We have been through 60 years of negativism and highly flawed, toxic rumor mongering on vitamin D3. Whether based on D1, D2, or more toxic analogs, or major mistakes in old test reports on dosage from very 3rd world countries, excessive calcium supplementation, or excessive vitamin A with liver disease and smokers. The basic fact is our medical institutions haven't done their homework on D3 right for generations and still aren't really getting to the nub of the answers directly.

I do not trust any negative off-the-cuff say-so at this point, I investigate when I hear new versions. Although there isn't a lot of high end data, some of what we have suggests some people with CRC do benefit and metabolize or excrete vitamin D3 at higher rates, hence become deficient more easily. Less does not sound like more to me.

My wife ran through about 2 million iu of vitamin D3 over several months (16-17,000 then 11-12,000 iu per day), one month presurgery to several months after, and still had lower vitamin D blood levels than these tests' goals of 80 nmol/L (32 ng/mL), which several D3 investigators believe to be inadequate for colon cancer based on their analyses of data and mechanisms.

Our kidney protection plan is to actively monitor total calcium, every 2-3 wks, and phosphorus. We keep the Ca-P product at 55 or below. The big alarm bells go off at 70. Other supplemental factors may protect the kidneys more. The big items that seem to affect calcium levels, besides vitamin D3 and calcium intake, are inflammation and chemo, both of which affect blood D3 levels in the medical literature, and maybe in our data. So we monitor inflammation too.

Also I've had three doctors sign off on high dose vitamin C protocols, including the Univ of Kansas protocol, including IV magnesium salts and oral B complex (folate replaced by folinate/leucovorin), up to 75-90 grams IV vitamin C per day, 3-7 days per week for 10 months now. No kidney issues here, the vitamin C helps to allow the 5FU-LV chemo treatment to continue, even helping to squelch a mucositis-stomatitis event due to folate-5FU toxicity buildup. This does not answer whether vitamin C interacts negatively/positively with oxaliplatin, although the question may be trickier than many think, "Show me the data".

We strongly believe in active monitoring of blood data, and we get it independent of insurance.