Feb 20, 2011 - 1:48 am
My husbaned had melanoma 12 years ago. It was classified as a stage 2 and involved a lision on his back and evidence of cancer in a sentinal node under in his armpit. Seven lymph nodes were removed at the time. Now, flash forward, three skin lisions appeared and after biopsies, pet scan, etc, he has been diagnosed as stage 4 with mets in his lungs, liver and bones. Fortunately, his MRI indicates nothing in his brain. He has been referred to UCSF and had his first appointment with Dr. Algazi on Friday. His tissue is being tested to see if he qualifies for a B-Raf trial to investigate BRAF inhibiter in combination tieh the MEK inhibitor. The BRAF part of the trial is a phase II study, but the MEK part is a phase 1, with a 2/3 chance of getting the medication. If he does not have the gene for B RAF they want him in a trial entitled: "A Two Arm Phase II Trial of Sequentail Axitinub and Carboplatin/Paclitaxel in Melanoma with Correclative FLT PET (CC#10852". The doctor doesn't think he would be a good candidate for interleukin because of some cardiac issues. UCSF also doesn't offer trials using IPI, but I have gotten mixed reviews on that.
Ok, my head is swimming and I'm not a doctor, and I'm overwhelmed by the information.