EBC 46

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snommintj
snommintj Member Posts: 601
edited March 2014 in Colorectal Cancer #1
Anybody heard anything? They were supposed to start human trial this month but I haven't heard anything yet. It works on just about every other mammal. I have to believe it'll work on humans.

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  • Unknown
    Unknown
    #2
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  • Buzzard
    Buzzard Member Posts: 3,043 Member
    #3
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    unknown said:

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    another piece of info on EBC-46





    News Australia reports that a breakthrough Australian drug that has cured cancer in animals with a wide range of solid tumors and is to be trialled on humans. The drug EBC-46, derived from plants from an Australian tropical rain forest, has dramatically reduced inoperable tumors in about 150 dogs, cats and horses.

    EBC 46 is a bioactive molecule The drug was developed over six years from the seed of a rainforest plant found in the Atherton Tablelands by QBiotics

    According to the QBiotics website, EBC 46 is applied directly by injection into the tumor, or applied as a gel to the tumor’s surface. It works by stimulating the body’s own defenses against the disease. It usually requires only one treatment, and it does not have the strong side effects of other cancer treatments.

    QBiotics chief executive Dr Victoria Gordon said scientists had cultivated their own plantation of the plant since forming QBiotics in 2004.

    EBC-46 is now available for veterinary markets in Australia and New Zealand. QBiotics has raised the $10 million needed be begin human trials on EBC 46, according to QBiotics corporate finance manager Rueben Buchanan, who said recently that phase one of the human trials would now begin in early 2011 as planned. The drug could potentially be available to the public within six years.

    QBiotics will seek approval from the US Food and Drug Administration before teaming up with a drug company to fund the $500 million rollout.
  • tanstaafl
    tanstaafl Member Posts: 1,313 Member
    #4
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    GEN info
    The one time direct contact application makes me wonder if EBC-46 has a potential future as a peritoneal application, a HIPEC variant. From Genetic Engineering & Biotechnology News, Sep 1, 2009, "EcoBiotics Scours Rainforest for Compounds":

    "The observation that rainforest marsupials spit out seeds after eating the fruit of a certain plant led to the company’s lead compound, EBC-46. Scientists at EcoBiotics learned that the unpalatable seeds contain an inflammatory agent that made the animals’ tongues swell. They isolated the active ingredient, a diterpene ester, which belongs to a new class of chemicals.

    "EBC-46 shows anticancer properties against basal and squamous cell carcinomas, melanoma, and head and neck tumors, Delco reports. The active ingredient in EBC-46 is easily purified from a ubiquitous plant species...

    "EBC-46 is a protein kinase C regulator that initiates apoptosis of tumor cells and causes a local inflammatory reaction that recruits the body’s neutrophils to attack the tumor. When injected into incurable soft tissue sarcoids, nasopharangeal cancers, and oral malignant melanomas in horses, dogs, and sheep, EBC-46 destroyed the tumors and healing was evident in about two weeks, Delco reports."
  • Unknown
    Unknown
    #5
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    tanstaafl said:

    GEN info
    The one time direct contact application makes me wonder if EBC-46 has a potential future as a peritoneal application, a HIPEC variant. From Genetic Engineering & Biotechnology News, Sep 1, 2009, "EcoBiotics Scours Rainforest for Compounds":

    "The observation that rainforest marsupials spit out seeds after eating the fruit of a certain plant led to the company’s lead compound, EBC-46. Scientists at EcoBiotics learned that the unpalatable seeds contain an inflammatory agent that made the animals’ tongues swell. They isolated the active ingredient, a diterpene ester, which belongs to a new class of chemicals.

    "EBC-46 shows anticancer properties against basal and squamous cell carcinomas, melanoma, and head and neck tumors, Delco reports. The active ingredient in EBC-46 is easily purified from a ubiquitous plant species...

    "EBC-46 is a protein kinase C regulator that initiates apoptosis of tumor cells and causes a local inflammatory reaction that recruits the body’s neutrophils to attack the tumor. When injected into incurable soft tissue sarcoids, nasopharangeal cancers, and oral malignant melanomas in horses, dogs, and sheep, EBC-46 destroyed the tumors and healing was evident in about two weeks, Delco reports."

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  • tanstaafl
    tanstaafl Member Posts: 1,313 Member
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    unknown said:

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    fast track...
    "immoral, illegal, and unscientific"
    Only if your cookies aren't in the fire. In four years, multiple whole new technologies were developed for a complex plutonium gadet. In seven years, we went from suborbital spam in a can, through three generations of spacecraft to men walking on the moon.

    Surely it isn't asking too much to get on with it in a year or two for external uses. Perhaps register it in China first, they might be more results oriented with a million potential volunteers.

    Thanks for keeping us updated, Graci.
  • OtherShoeFell
    OtherShoeFell Member Posts: 37
    #7
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    unknown said:

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    Hi Graci - As an RN....
    ...have you ever heard of the "Compassionate/Emergency Use" of INDs (Investigational New Drugs) or is that not generally done outside of larger academic institutions? I ask this not with an air or any sense of nastiness, but just out of general curiousity, as I see where this might be of value. I don't know whether it would apply to veterinary approved drugs, but it might be worth looking into...I don't think it's called on (used) very often because there's a lot of paperwork involved...
  • Unknown
    Unknown
    #8
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    OtherShoeFell said:

    Hi Graci - As an RN....
    ...have you ever heard of the "Compassionate/Emergency Use" of INDs (Investigational New Drugs) or is that not generally done outside of larger academic institutions? I ask this not with an air or any sense of nastiness, but just out of general curiousity, as I see where this might be of value. I don't know whether it would apply to veterinary approved drugs, but it might be worth looking into...I don't think it's called on (used) very often because there's a lot of paperwork involved...

    This comment has been removed by the Moderator

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