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Breast Cancer and TNF blockers

Posts: 1
Joined: Dec 2010

I am a two time breast cancer survivor (2003 and 2010) facing a difficult decision. In 2008 I was diagnosed with a rare and particularly aggressive form of rheumatoid arthritis, Palindromic Rheumatism that persists today.

Unlike regular RA, this one does not cause joint damage but the attacks are more frequent and more severe. Without medication I am in extreme pain and nearly invalid. I've tried every medicine we can find but nothing works, so now I'm down to the new biologics. Because the bioogics can cause lymphoma, I am really struggling with this decision.

To summarize, biologics work with "...TNF blockers that target and neutralize tumor necrosis factor-alpha (TNF-α), a protein that, when overproduced in the body due to chronic inflammatory diseases, can cause inflammation and damage to bones, cartilage and tissue. The drugs in this class include Remicade (infliximab), Enbrel (etancercept), Humira (adalimumab), Cimzia (certolizumab pegol) and Simponi (golimumab)...An analysis of U.S. reports of cancer in children and adolescents treated with TNF-blockers showed an increased risk of cancer, occurring after 30 months of treatment on average. About half of the cancers were lymphomas, a type of cancer involving cells of the immune system. Some of the reported cancers were fatal." This was taken from an FDA website warning and there is no real data for adults--or breast cancer survivors--since the drugs are so new, so we must assume the risk is present for us as well.

My question: has anyone else faced this problem? Does anyone have any information or personal history they can share with me? I could really use some additional information to consider.

TraciInLA's picture
Posts: 1942
Joined: Jul 2009

I don't have any experience with these drugs or RA, but just wanted to welcome you here, say how sorry I am that you're facing such pain and difficult decisions, and bump up this post for others -- has anyone else out there taken Enbrel, Humira, Simponi, Remicade, or Cimzia?


Sher43009's picture
Posts: 602
Joined: Nov 2009

My sister has RA (not sure which kind, but has joint disfigurement). She was dx when she was 35 years old, she's now 53. She's had 5 joint replacements, been on Enbrel, that didn't work too well, then switched to Humira. She's been on that since it's been approved and it is helping but has not put it into remission. She's on full disability as she can't work, and on heavy pain meds. Pain meds effect those with cronic pain differently then those who don't so she can still function. Thankfully so far she has not had any cancer. As you know there is no cure for RA and her feeling is life quality vs. quantity. She's a real inspiration to me for she doesn't let this stop her. She is a wonderful cook, volunteers at her church and library.

I hope this helps

heidijez's picture
Posts: 441
Joined: Mar 2010

was diagnosed over 10 years ago with RA and 6 soft tissue and muscle diseases. have been on enbrel for more than 9 years - it truly was a miracle drug for me, gave me my life back. was on remicade for a while, but that drug almost killed me.

when i found the swollen lymph nodes last november, my mind immediately went to lymphoma (one of the possible side effects of enbrel) according to my team of doctors there is no connection to my rheumatoid arthritis and the cancer i am currently dealing with (inflammatory breast cancer and triple negative)

not sure what other information i could offer, but am certainly willing to share MY experiences. good luck to you and remember, i am here for you if you need me.

Kelly K
Posts: 1
Joined: Feb 2011

I just returned from an appointment with my rheumatologist yesterday... she is treating me for rheumatoid arthritis, Sjogren's Syndrome and fibromyalgia. Last month I had a lumpectomy which showed precancerous cells in the breast tissue. My rheumatologist was going to put me on a TNF blocker but, because of the results of my lumpectomy, she would not go that direction. She is very concerned with the risk of malignancy associated with TNF blockers (as am I). I certainly understand the pain associated with RA and the hope for potential relief from a TNF blocker (I was a bit discouraged knowing that isn't a path I can travel down at this point). I have great respect for my rheumatologist and trust her lead in this. So, for now I continue on with my current (less effective) medications... trusting my rheumatologist's caution and pressing on...

Posts: 1
Joined: Mar 2013

Dear Kelly,

I know what you are going through. I have a fairly healthy lifestyle and no family history of breast cancer, yet was recently diagnosed with Stage I breast cancer.  Had to go through lumpectomy, 12 rounds of chemo and radiation, and now Ihave couple of rounds of herceptin chemo to go through.  Also I just started tamoxofin.  It is physically and emotionally draining.  I have  RA, and for the last 7 years been on enbrel.  I did feel great, but now I feel and my oncologist thinks that perhaps enbrel had a role, as Enbrel is a drug where the immune system is compromised.

I am glad that you have such a wonderful rheumatologist.  Yes, do follow her advice.  My rheumatologist also wants to be in an another drug possibly plaquinil..but he told me that this will not be that effective.  What medicine are you on?  While I think I am incredibly lucky that I accidently found this small lump,sometimes  I do have the 'why me syndrome'!!!  I was hoping that one could control RA by just diet and exercise.  My rheumatologist shared with me that there is no such thing.  It could work for some time, but then will not work for after a while..so hoping for the best for the coming years. 

When you have a chance, please let me know what medication you are in for your RA.

Take care.




Posts: 1
Joined: Jul 2013

I started Humira August 2010 for Ulcerative Colitis.  In October 2012 I was diagnosed with Triple Negative Breast Cancer, with absolutely no cancer in my family.  I was told by my gyn and my gastro doctor to immediately stop taking the Humira. I underwent 16 rounds of chemo, a partial mascectomy and 7 weeks (35 days) of radiation. Can anyone share a similar situation? 



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