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Glutamine Powder

Pumakitty's picture
Pumakitty
Posts: 652
Joined: Mar 2010

Is this safe to take with Chemo. I have read many things interfer with Chemo and I just want to make sure.

Also, does anybody know if the throat care teas are safe to dring during chemo.

Thanks, again for for all the advice.

stevenl's picture
stevenl
Posts: 587
Joined: Jan 2010

Hi,

I have taken the powder all through treatment and it seems to help with the burning and I had no side effects. Unsure about the teas though. I drink green teas all the time.

Best,
Steve

Pumakitty's picture
Pumakitty
Posts: 652
Joined: Mar 2010

How often and how much did you use in a day. I know that is 1 teaspoon for 8 ounces of water, but how many glasses a day. Did you just use the one off and one for the whole day?

Scambuster's picture
Scambuster
Posts: 973
Joined: Nov 2009

Hi Puma,

I found this site sells a good brand that I use (Made in the USA). Other sites would sell too I'm sure so check for the best price and shipping.http://www.integrativepsychiatry.net/glutamine_powder_vital_nutrients.html

Dosage is also noted on this site : 1-2 teaspoons in a glass of water 3-4 times a day.

Here is also a good site explaining the benefits and function of Glutamine powder >http://www.vitalnutrients.net/hq_handouts2.asp?VitaminName=Glutamine%20(Powder)

As it is a natural and essential Amino Acid, It should not affect treatment - however just check with your Doctors or even better a Naturopath as your Doctor would probably not know about it's use in healing. They will most likely only know it as a supplement for body builders. I was prescribed it by a leading Naturopath who knew I was in treatment.

Scam

Pumakitty's picture
Pumakitty
Posts: 652
Joined: Mar 2010

I think I will order some. My dad's mouth is really starting to burn now, I think it might also be coming from his first Chemo as much as from the rads.

He does not like the magic mouth wash. He says it makes him feel sick. He is using the spray that was recommended. I would just like to do all that I can to prevent some of worst sores.

Kathy

CajunEagle's picture
CajunEagle
Posts: 387
Joined: Oct 2009

I agree with your Dad, that Magic Mouthwash is some nasty stuff. I had no problem swishing it around in my mouth, but there was no way I could swallow it. As I recall, it tasted horrible.....to me anyway. I just stuck with the baking soda and salt solution. I got chewed out quite a few times for not swallowing the MM, because swallowing it is the trick to help the mouth sores, But this ole boy just couldn't get it down.

Larry

sweetblood22's picture
sweetblood22
Posts: 3228
Joined: Jan 2010

Now that I have a car and am driving, I finally made it to the health food store I wanted to go to. I checked for the L-Glutamine and they only had it in a pill. Which I could not swallow anyway. I was mot sure if it would disolve in water. Or how much I would take because I remember Scam saying something about sachets. Or packets, I guess. I will check out those links too.

Scambuster's picture
Scambuster
Posts: 973
Joined: Nov 2009

Check above in this thread about buying online and also a good brand. You are best to get the loose powder (not sachets). Hope it help your mouth pain and overall healing.

Scam

Greg53's picture
Greg53
Posts: 848
Joined: Apr 2010

I've seen several people recommend L-Glutamine on this site. I did some research and then talked to my ONC and RAD doc's. Both recommended using it (why didn't they tell me that before??) and everything I read looks like anyone with throat cancer might consider it as a good option. Bought some yesterday. Hopefully works for me too.

PS - Steve. I saw your email about the two of us being on same timeline. Biopsy for me on 1/22/10. Tonsillectomy and dissection on 1/27/10. Rad/chemo ended 4/12/10. Sounds like you are doing well. Hope so! It seems like I'm turning the corner and getting a handle on all my issues. Good luck.

Greg

Greg53's picture
Greg53
Posts: 848
Joined: Apr 2010

I've seen several people recommend L-Glutamine on this site. I did some research and then talked to my ONC and RAD doc's. Both recommended using it (why didn't they tell me that before??) and everything I read looks like anyone with throat cancer might consider it as a good option. Bought some yesterday. Hopefully works for me too.

PS - Steve. I saw your email about the two of us being on same timeline. Biopsy for me on 1/22/10. Tonsillectomy and dissection on 1/27/10. Rad/chemo ended 4/12/10. Sounds like you are doing well. Hope so! It seems like I'm turning the corner and getting a handle on all my issues. Good luck.

Greg

stevenl's picture
stevenl
Posts: 587
Joined: Jan 2010

Hey Greg,

Yea I finished treatment 4-9-10, and am doing real well. Hang in there you will make around that corner.

Best,
Steve

kcinpdx
Posts: 13
Joined: Feb 2011

Glutamine was recommended by my Oncologist to offset chemo and radiation effects to help rebuild my gastrointestinal tract, immune system and regain muscle weight I lost. I bought pharacetical grade 1000 mg (1 gram) tabs and would dissolve one a day in water and drink it. I did experience positive benefits with no side effects.

hawk711's picture
hawk711
Posts: 566
Joined: Jan 2010

Hi all
I am 10 months out of treatment, is glutamine good for me now??? or is it to be used during rads and chemo? I'm looking for saliva growth in any way possible if you all have ideas. I take Evoxac right now and it is supposed to help, but seems to little.

Greg, thanks for the update. I finished April 1st (Fools Day) and got a clean PET scan in January. Glad to hear you are tracking on the same page as me. I feel wonderful, just can't eat anything starchy, i.e. bread, pasta, etc. It balls up in my mouth and I have to push it down with water/milk. Keep me posted on your progress and I'll do the same.

All the best,
steve

Scambuster's picture
Scambuster
Posts: 973
Joined: Nov 2009

Hi Steve,

The L Glutamine powder is not known to specifically help with the Saliva function unfortunately but it it does so many other good things, it certainly is beneficial to overall well-being. Good to help gain some muscle tissue you may have lost and help the gut and mouth tissue recover.

For the saliva, I had been getting acupuncture for over a year and i think it has helped. I carry a pack of Eclipse non sugar type little mints that help stimulate Saliva, but I think they are more a parasympathetic stimulant to the 100's of tiny S glands we have throughout our mouths. The big 3 pairs of S Glands are mostly shot, but I still have hope of some recovery so i will continue to try.

Good luck with it all.

Scam

sweetblood22's picture
sweetblood22
Posts: 3228
Joined: Jan 2010

I didnt start using the Glutamine until I was 16 months or so out. I think it helps with burning and my tongue pain. I keep a bottle of water with a tsp in it with me at all times. It makes the water tolerable for me to drink. I also put it in my freshly juiced fruit/veg. I cannot drink it without it. I have been feeling even dryer lately with my mouth. I thought it was supposed to get better, not worse. I know I will always be pretty dry because I am missing my left submandiblar.

JackLondon
Posts: 1
Joined: Jul 2011

Glutamine Powder mixed with Room Temperature water will heal your gut lining and also other mucous membranes - I've been using it myself for over 6 months and have recommended it to five friends that also take it and all see positive benefits using it. It helps boost the immune system, helps give energy, it really does a lot of good that it should be given by doctors as a matter of course.

However I believe it's not a good thing to mix it with water and just leave it in a bottle - I believe that as soon as it gets wet it starts changing form and that you need to drink it quickly.

RogerRN43
Posts: 185
Joined: Sep 2011

Is this what I should be getting?
(I live in Canada)

http://www.costco.ca/Browse/Product.aspx?Prodid=10314461&lang=en-CA

Take as directed while on rads and after?

sweetblood22's picture
sweetblood22
Posts: 3228
Joined: Jan 2010

Looks right to me. I wish I could send you the extra jar I have because I'm not using it every day like I was.

I was told to take 5 g a day, or one heaping tsp in one cup water. Swish and swallow. Through rads and after. Make sure it's ok with your doc. There have been one or two that have said no, though I don't know why.

I would send you my jar, if you would like, and if I am allowed to send it to you in Canada. Free of charge. PM me if you are interested.

osmotar's picture
osmotar
Posts: 1002
Joined: Jul 2011

What does this do for you?

RogerRN43
Posts: 185
Joined: Sep 2011

How do I pm? Add as a friend first?

sweetblood22's picture
sweetblood22
Posts: 3228
Joined: Jan 2010

I see you figured it out. :)

dygit's picture
dygit
Posts: 34
Joined: May 2016

Here are three commonly used regimens in the prevention of mucositis (oral, throat or esophageal) and peripheral neuropathy:

You can buy glutamine (usually in the form of L-glutamine), in powder, capsule, tablet, or liquid form. However, I recommend using the powder form of L-glutamine, and mixing it in with cold or room temperature liquids (water or juice.) It should not be added to hot beverages because heat destroys glutamine. Glutamine therapy works best if started at the time of beginning radiation therapy or chemotherapy. It will be less effective if you start this after already showing signs or symptoms of mucositis or peripheral neuropathy.

For The Prevention Of Oral mucositis (OM)

* DOSE: Mix 10 grams of powdered glutamine in a small glass (6-8 ounces) of water or juice. Swish and gargle for 30-60 seconds and swallow. You can continue to do this until the 6-8 ounces are gone. Repeat every 8 hours (schedule: morning, mid-day, evening)

* Start this regimen on the first day of chemotherapy and continue for 14 days after the last dose of chemotherapy in patients who do not develop OM or until 5 days after resolution of OM for patients who experienced OM.

* Other recommendations:

    * Refrain from eating or drinking for 30 minutes after dosing.

    * Adhere to good oral hygiene practices and gently brushed their teeth twice daily, 30 minutes or more after using glutamine, using a soft toothbrush and fluoride toothpaste.

    * Daily flossing and an alcohol-free fluoride rinse is recommended.

* This is based on a study that showed a significant reduction in OM among patients using oral glutamine.

    * These investigators used a proprietary glutamine suspension (Saforis, MGI Pharma, Inc., Bloomington, MN), which was administered at a dose of 2.5 g per 5 mL 3 times per day for a total daily dose of 7.5 g. This product reportedly is able to be better absorbed into the oral mucosa than standard glutamine. (I believe that this can be compensated for by using a higher dose, 10 grams, 3-times per day, of standard glutamine, as recommended above.)

    * Various chemotherapy regimens used in this study (21-day cycle): cyclophosphamide, doxorubicin, and 5-fluorouracil (CAF); 5-fluorouracil, doxorubicin, and cyclophosphamide (FAC); or doxorubicin and cyclophosphamide (AC).

    * Compared with placebo, glutamine significantly reduced the incidence of moderate-to-severe OM 39% vs. 50% (placebo.)

For prevention of mucositis of the throat and esophagus (esophagitis) from radiation and chemotherapy:

* DOSE: Mix 10 grams of powdered glutamine in a small glass (6-8 ounces) of water or juice. Drink (swallow). Repeat every 8 hours (schedule: morning, mid-day, evening)

* Start this regimen 1 week before radiation therapy and continue for 2 weeks after completion of radiation therapy.

* This is based on a study that showed a significant reduction in esophagitis among patients receiving this regimen versus no glutamine:

    * There was minimal-to-no-esophagitis was seen in 71% of the glutamine supplemented patients versus only 44% without glutamine

    * By the end of treatment, the glutamine supplemented patients gained 2.6 kg (median), while those without glutamine lost 3.3 kg (median)

    * There was a significant delay to the time of first noticing esophagitis in the glutamine patients versus the non-glutamine patients: 25 days versus 16 days.

    * There were also fewer treatment breaks, hospitalizations and late esophageal toxicities among the patients who took glutamine versus those who did not.

    * Importantly, there were no differences in cancer recurrence rates at 24 months of follow-up (the glutamine did not reduce the effectiveness of treatment.)

 

For the prevention of chemotherapy-induced peripheral neuropathy(studied with oxaliplatin and paclitaxel)

* DOSE: Mix 15 grams of powdered glutamine in a small glass (6-8 ounces) of water or juice. Drink. Repeat every 12 hours (schedule: morning and evening)

* Start this regimen on the day of oxaliplatin infusion and continue for seven days thereafter. Repeat with each infusion.

* This is based on a study that showed a significant reduction in chemotherapy-induced peripheral neuropathy among patients receiving this regimen versus no glutamine:

    * After all 6 cycles of chemotherapy, 48% of patients in the glutamine group had no peripheral neuropathy (PN) versus only 27% in the non-glutamine group.

    * After all 6 cycles of chemotherapy, 12% of the patients in the glutamine group had moderate-to-severe PN versus 32% in the non-glutamine group.

    * Glutamine supplementation significantly improved cold intolerance and lessened the interference to activities of daily living.

    * Chemotherapy dose-reductions were less frequently needed in the glutamine patients (7%) versus those not taking glutamine (27%)

    * There were no differences found in the response to chemotherapy or survival between the two groups.

 

How Does Glutamine Reduce Mucositis and Esophagitis?

Glutamine has been shown to reduce the degree of mucositis through:

* anti-inflammatory mechanisms (inhibition of one of the main switches that turn on inflammation, NF-kappaB)

* inhibition of bacterial toxins

* increased tissue healing (increased fibroblast and collagen synthesis.)

How Does Glutamine Reduce Chemotherapy-Induced Peripheral Neuropathy?

We don’t know exactly, however it is believed that glutamine may exert its neuroprotective effects by upregulation of nerve growth factor. In animal studies, supplementation with glutamine appears to increase NGF.

 

Is Glutamine Safe To Give To Patients With Cancer?

This is an area of controversy, as it is well-known that under certain circumstances cancer cells use glutamine for energy even more voraciously than glucose.

However, no human study, have ever shown that glutamine increased tumor growth rates or decreased the efficacy of other cancer therapies.

Over the last 20 years, 36 clinical studies have demonstrated the tolerance, safety and effects of glutamine (oral and IV) in patients undergoing chemotherapy and/or radiation therapy. In each of these studies, researchers have reported that glutamine supplementation in cancer patients improves their metabolism and clinical situation without increasing tumor growth. 

Potential Side Effects and Drug Interactions:

Generally, very well-tolerated and is considered safe for use by most people for the duration of cancer care (chemotherapy and/or radiation therapy) in doses up to 40 grams per day (adults.) 

Do not use glutamine if you:

* Have kidney failure, kidney dysfunction, or if your kidney function is impaired or abnormal.

* Have liver failure, liver dysfunction, or if your liver function is impaired or abnormal.

* Have ever been diagnosed with or had a period of hepatic encephalopathy (liver function that affects your mental, emotional, or cognitive state).

* Have a history of mental illness, especially bipolar depression (manic depression), mania, or hypomania.

* Have a history of seizure disorders, such as epilepsy or are taking medications to control a seizure disorder.

* Have a history of allergic reaction to monosodium glutamate (MSG), a flavoring agent sometimes used in the preparation of Chinese food in restaurants.

* Are taking or have been prescribed to take a medication called lactulose.

Adverse drug-glutamine interactions are not common, but (as with any supplement) always check with your physician before starting glutamine.

Read about side effects and potential drug interactions here: WebMD

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