Mar 12, 2010 - 10:04 am
I have been on Femara for almost a year now and I've noticed some cognitive problems and SEVERE insomnia. I found some research on the effects of estrogen on the brain: it affects the serotonin receptors and there are indication that it helps with memory. I watched my father die of early onset Alzheimer's (he was one of the few who actually died of the disease and not a side effect--he lasted over twenty years, ten of them in a vegetative state) and now my mother is showing signs of dementia. Aromatose inhibitors prevent estrogen from getting into your system, so our brains do not get the benefits. WE already know the effect of a lack of estrogen on bones, but nobody mentions the effects on our brains. I would rather take my chances with a recurrance of cancer than increase my risk of dementia. Does any know of any research that has investigated the effects being on aromatose inhibitors--Femara, Arimidex, etc--long term have on the brain?